Oligonucleotide Senior Scientist

Responsibilities

• Design, develop, and optimize chemical synthesis processes for nucleotides and oligonucleotides
• Process development and scale-up from R&D to manufacturing
• Develop and improve oligonucleotide purification processes (e.g., HPLC, ion-exchange, desalting)
• Troubleshoot synthesis and purification challenges to improve yield and purity
• Collaborate with manufacturing, QC, and engineering for process transfer
• Evaluate new chemistries and technologies
• Author SOPs, batch records, and technical reports
• Ensure compliance with quality systems
• Mentor lab technicians

Qualifications

• Ph.D. or Master’s degree in Organic Chemistry or related field (required)
• Minimum 5 years of industrial experience in chemical synthesis
• Hands-on experience with solid-phase oligonucleotide synthesis
• Hands-on experience in oligonucleotide purification process development
• Strong analytical skills (HPLC, LC-MS)
• Experience scaling processes to manufacturing
• Experience in GMP or regulated environments (preferred)
• Familiarity with automated DNA/RNA synthesizers (strongly preferred)
• Knowledge of modified nucleotides (strongly preferred)
• Experience in high-throughput oligo production (strongly preferred)
• Authorization to work in the United States indefinitely without restriction or sponsorship
• Fast-paced, collaborative environment
• Ability to manage multiple priorities
• Occasional off-hours support as needed

Benefits

• Excellent full-time benefits including comprehensive medical coverage, dental, and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays

Schedule

Position is full-time working Monday - Friday 8:00am - 5:00pm, with overtime and weekend work as needed.