Oligonucleotide Scientist II

Key Responsibilities

• Work in an oligonucleotide therapeutic drug discovery research lab
• Interface across different therapeutic areas, including neuroscience, immunology and oncology
• Help build a comprehensive therapeutic discovery strategy
• Good understanding and troubleshooting experience in oligonucleotide synthesis, impurity profiling is a plus
• Collaborate with other scientists to maintain common lab equipment such as oligo synthesizers, HPLC and desalting units
• Perform literature reviews, propose, and execute nucleic acid chemistry plans
• Coincide chemistry and biology data to support oligonucleotide compound progression
• Establish methods for scaled-up synthesis of lead molecules
• Coordinate material delivery for preclinical studies
• Maintain a high level of productivity in the laboratory setting to meet timelines for in vitro and in vivo studies

Requirements

• Hands-on experience in oligonucleotide synthesis using automated oligo synthesizers, novel nucleic acid chemistry, oligonucleotide purification and characterization using HPLC and mass spectrometry
• BS/MS in Organic Chemistry or related discipline
• Pharmaceutical or biotechnology industry experience in research and development of RNAi therapeutics preferred
• A good understanding of nucleic acid therapeutic modalities, modification chemistries, sequence selection, and mechanism of action preferred
• Relevant experience in oligonucleotide therapeutics, large molecule drug discovery, oligonucleotide delivery or bio-conjugation desirable
• Strong communication and interpersonal skills essential

Pay

Pay Rate Range: $40-51/hr depending on experience