Oligonucleotide Scientist II

Position Overview

We are seeking a Scientist II to support oligonucleotide therapeutic discovery and development programs. This role will focus on oligonucleotide synthesis, purification, characterization, and scale-up activities while partnering with cross-functional teams to advance therapeutic candidates.

The ideal candidate will have hands-on experience with oligonucleotide chemistry, automated synthesis platforms, and analytical characterization techniques.

Key Responsibilities

• Perform oligonucleotide synthesis, purification, and characterization to support discovery research programs.
• Operate, maintain, and troubleshoot automated oligonucleotide synthesizers and associated laboratory equipment.
• Utilize HPLC, mass spectrometry, and related analytical techniques to assess product quality, purity, and identity.
• Support impurity profiling, process optimization, and troubleshooting activities.
• Contribute to experimental design, data interpretation, and scientific strategy through literature review and research activities.
• Collaborate with multidisciplinary teams to integrate chemistry and biology data and support candidate progression.
• Develop and optimize scalable synthesis methods and support material generation for preclinical studies.
• Maintain accurate laboratory records and prepare technical reports and presentations.
• Support laboratory operations while meeting project timelines and research objectives.

Required Qualifications

• Bachelor's or Master's degree in Organic Chemistry, Medicinal Chemistry, Chemical Biology, or a related scientific discipline.
• Hands-on experience with oligonucleotide synthesis using automated synthesizers.
• Experience with nucleic acid chemistry, oligonucleotide purification, and analytical characterization.
• Proficiency with HPLC, mass spectrometry, and related analytical techniques.
• Strong troubleshooting, analytical, and problem-solving skills.
• Excellent written and verbal communication skills.
• Ability to work independently and collaboratively in a team environment.

Preferred Qualifications

• Experience in oligonucleotide therapeutics, RNA-based therapeutics, or nucleic acid drug discovery.
• Experience in pharmaceutical, biotechnology, or related research and development environments.
• Knowledge of nucleic acid therapeutic modalities, modification chemistries, sequence design, and mechanisms of action.
• Experience with oligonucleotide delivery technologies, bioconjugation, or large molecule drug discovery.
• Experience supporting scale-up synthesis and material production for preclinical studies.

Benefits

Full-time employees are also eligible for benefits options such as health coverage, life insurance, disability insurance, and 401k benefits.