Nanomedicine and Breast Cancer Imaging Postdoc Fellowship

Description

The Cormode lab in the Radiology Department is seeking a highly motivated Postdoctoral Fellow to join an interdisciplinary research team developing next-generation nanoparticle contrast agents for the early detection of breast cancer. The successful candidate will contribute to an NIH-funded project focused on the translation of novel silver telluride nanoparticles (Ag₂Te-NP) for contrast-enhanced mammographic imaging in women with dense breasts. The project aims to advance a promising imaging technology toward clinical translation and eventual first-in-human studies.

Project Overview

Breast cancer remains a leading cause of cancer-related mortality among women. While mammography has significantly improved early detection, its sensitivity is reduced in women with dense breast tissue, who also face a substantially elevated risk of developing breast cancer. This project seeks to address this important clinical challenge by developing and clinically translating a novel nanoparticle-based contrast agent optimized for dual-energy mammography. Our laboratory has demonstrated that silver telluride nanoparticles provide substantially improved imaging performance compared with conventional iodinated contrast agents while exhibiting favorable clearance and safety characteristics. The current project will focus on scalable manufacturing and preclinical evaluation.

Research Areas

• Development and optimization of microfluidic synthesis methods for nanoparticle production.
• Physicochemical characterization of nanoparticle formulations.
• Evaluation of imaging performance using x-ray imaging, dual-energy mammography, and computed tomography (CT).
• In vitro studies of nanoparticle biocompatibility and performance.
• In vivo imaging, biodistribution, clearance, and safety studies.
• Quantitative image analysis and pharmacokinetic modeling.

Candidates requiring visa sponsorship are welcome to apply.

Qualifications

• PhD, MD/PhD, or equivalent doctoral degree in Biomedical Engineering, Bioengineering, Chemical Engineering, Materials Science, Nanotechnology, Medical Physics, Chemistry, Pharmacology, Imaging Sciences, or a related field.
• Strong record of scientific productivity, demonstrated by peer-reviewed publications.
• Experience in one or more of the following areas:
• Nanoparticle synthesis and characterization
• Microfluidics
• Molecular or biomedical imaging
• Preclinical imaging
• Drug delivery or nanomedicine
• Biomaterials research

Excellent written and oral communication skills.

Application Instructions

Applicants should submit a cover letter indicating their interest in the position, their CV, and the contact information of three references through Interfolio.