Mixed Modality (Oligonucleotide) Scientist

We need to output HTML fragment with sections: Overview, Organization And Position Overview, Responsibilities, Basic Requirements, Additional Preferences, Other Information (maybe include location, travel, etc). Also include Pay and Benefits if present: there is compensation range and benefits description. So we need Pay section with salary range and bonus info. Benefits section with description of benefits. Also maybe include Schedule? Not present. So we omit Schedule. We must not repeat job title. Use

for each section heading. Use

• for any list of duties/requirements/benefits. Use

  for prose. We must preserve all substantive information, not invent or summarize away detail. Remove boilerplate: EEO statements, accommodation request, etc. Also remove duplicated lines, navigation, cookie, legal, scam-warning. Also remove the repeated EEO paragraphs. Also remove the "#WeAreLilly" tags. Also remove the accommodation request form link? That's part of EEO/accommodation boilerplate; we should remove. Also remove the "Lilly is an EEO/Affirmative Action Employer..." etc. Also remove the employee resource groups list? That's also EEO/boilerplate; likely remove. Also remove the "Actual compensation will depend..."? That's part of compensation description; we need to keep compensation details. The sentence about actual compensation depending on education etc is substantive? It's generic but still part of compensation description; we can keep it as part of Pay section. The benefits description is substantive; keep. We need to include location info: "Initial location at Lilly Technology Center, Indianapolis and/or Parkwood West Permanent location at the new Lilly Medicines Foundry in Lebanon, Indiana." Also travel limited domestic/international Overview

with

. Organization And Position Overview: includes Lilly Medicine Foundry investment, description, PTE team role, etc. We'll put under

Organization And Position Overview

with paragraphs. Responsibilities: list of duties. We'll put under

Responsibilities

with

• each bullet. Basic Requirements: list of requirements. Use
  • . Additional Preferences: list of preferences. Use
    • . Other Information: includes location, travel, work environment, maybe also note about compensation? Actually compensation is separate. We'll put location, travel, work environment under

      Other Information

      with

      or

      if list. Pay: includes salary range, bonus eligibility. We'll put under

      Pay

      with

      . Benefits: includes description of benefits program. We'll put under

      Benefits

      with

      (maybe also list but it's prose). Could also bullet but not needed. We must not include sections like Schedule. Now ensure we don't include any boilerplate: EEO statements, accommodation request, resource groups, "#WeAreLilly". Also remove duplicated lines like "Lilly is an EEO/Affirmative Action Employer..." appears twice; remove both. Also remove the "Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs..." maybe that's part of benefits description? It's a legal disclaimer; could be considered boilerplate. The instruction says remove cookie/navigation/legal/EEO/equal-opportunity/scam-warning boilerplate. That sentence is legal disclaimer about compensation and benefit programs; likely considered legal boilerplate. Should we remove? It's part of the benefits description but it's a disclaimer. The instruction says remove legal boilerplate. So we should omit that sentence. Keep the rest of benefits description. Also remove "Actual compensation will depend on a candidate’s education, experience, skills, and geographic location." That's not legal boilerplate; it's substantive about compensation determination. Keep. Now let's craft HTML. We'll need to escape any special characters? Not needed. Let's draft:

      Overview

      At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader, headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

      Organization And Position Overview

      Lilly recently announced a $4.5 billion investment to create the Lilly Medicine Foundry, a new center for advanced manufacturing and drug development in Lebanon, Indiana. The first‑ever facility of its kind combines research and manufacturing in a single location, allowing Lilly to further develop innovative solutions to optimize manufacturing processes and increase capacity for clinical trial medicines while reducing costs and environmental impact. The Process Translation and Execution (PTE) team translates API/DS process knowledge into clinical supply readiness, oversees technology transfer, implements phase‑appropriate control strategies, and ensures right‑first‑time clinical manufacturing for a variety of modalities, including synthetic molecules, biologics, peptides, oligonucleotide, and bioconjugates (ADC, ARC, etc.). Through cross‑functional collaboration, PTE influences process design, revolutionizes clinical manufacturing, builds capabilities in emerging technologies and aligns with corporate and Lilly Research Labs (LRL) goals, drives scientific excellence and innovation to accelerate manufacturing advancements and propels the site toward long‑term business success. In the Foundry Construction and Project Delivery/Startup Phase (2025 to 2028), roles will be fluid and dynamic as we build a new organization, design and implement the necessary systems and business processes required to enable operational readiness, support the project delivery, and build the site culture. Success will require significant collaboration, creativity, and resilience as the Lilly Medicine Foundry transitions from design to startup and ultimately to steady‑state operations and continuous improvement. This period presents a unique opportunity for learning, growth, and making a lasting impact. We are seeking passionate and agile scientist to join the PTE team and help bring the Lilly Medicine Foundry’s vision to life.

      Responsibilities

      • Evaluate and facilitate the transfer of oligonucleotide manufacturing processes, under appropriate supervisory guidance, from development laboratories to pilot plant operations (including kilo‑scale and isolator production environments).
      • Enable the successful transition to early‑phase cGMP manufacturing of grams to kilogram quantities of API required for clinical trial supply.
      • Oversee the successful transfer of new oligonucleotide processes from development to manufacturing; ensure scalability and process fit to plant; apply scientific knowledge to troubleshoot production issues and implement new technologies or procedures.
      • Assess and scale‑up synthesis and purification methods from early phase process research and development labs.
      • Familiarity with performing oligonucleotide procedures, such as solid phase synthesis, preparative chromatography, TFF, & lyophilization.
      • Evaluate the safety of the incoming procedures in collaboration with the safety group and process engineering.
      • Analyze analytical data to make fact‑based decisions.
      • Efficiently summarize and present chemistry and challenges.
      • Lead familiarization executions to ensure plant readiness of process steps including synthesis, cleavage, purification, TFF, & lyophilization at the Lilly Medicine Foundry.
      • Perform use‑tests of key in‑process materials and document Definitive Lab Trials of processes to confirm plant readiness.
      • Documentation: Author, review technical documents, including tech transfer plan, standard operating procedures (SOPs), batch records, campaign summary reports, and deviation reports.
      • Process improvement: Apply scientific knowledge to identify areas for improvement and implement new technologies or procedures.
      • Lead process‑related investigations, assess deviations, and support CAPAs; collaborate closely with CMC, Product R&D, Manufacturing, and Quality teams; provide on‑floor support for critical operations and train/mentor junior scientists and technicians in PTE activities.

      Basic Requirements

      • B.S. or M.S. in Chemistry, Biochemistry, Chemical/Biochemical Engineering, or a related discipline.
      • B.S. with 10+ years or M.S. with 7+ years of experience in Oligonucleotide Product/Process Development, Manufacturing Technical Services, or related functional roles.
      • Qualified applicants must be authorized to work in the United States on a full‑time basis. Lilly will not provide support for or sponsor work authorization or visas for this role, including but not limited to F‑1 CPT, F‑1 OPT, F‑1 STEM OPT, J‑1, H‑1B, TN, O‑1, E‑3, H‑1B1, or L‑1.

      Additional Preferences

      • Strong knowledge of oligonucleotide process (upstream or downstream), including synthesis, cleavage & deprotection, chromatography, conjugation, and aseptic processing.
      • Proven ability to analyze data, perform root cause analysis, and resolve complex technical challenges; solid understanding of biopharmaceutical manufacturing principles and cGMP requirements.
      • Demonstrated success in cross‑functional, dynamic, and matrixed environments; excellent written and verbal communication skills for technical report writing, presentations, and team collaboration.
      • Previous experience leading small projects, coordinating activities, and managing timelines; supervisory experience of junior scientists or technicians highly preferred.
      • Proactive engagement with external innovation and industry trends; proven ability to champion accelerated adoption of transformative technologies in manufacturing environments.
      • Experience with oligo synthesis and purification techniques used for developing and scaling‑up process reactions. Experience using process chemistry concepts is a plus.
      • Comfortable working with larger sized reactors and preparative columns, TFF, and related‑equipment.
      • Highly motivated, able to learn rapidly, and demonstrates strong attention to detail.
      • Has experience creating batch records and conducting scale‑up experiments according to those records.
      • Ability to prioritize multiple activities and manage ambiguity.
      • Experience with a variety of analytical techniques: HPLC/UPLC, LC‑MS, GC, etc.
      • Process quantification and acquiring mass balance for products and by‑products.
      • Communication skills: Excellent written and verbal communication skills for technical report writing, presentations, and effective collaboration across teams.
      • Problem‑solving skills: Proven ability to analyze data, perform root cause analysis, and resolve complex technical challenges.

      Other Information

      Initial location at Lilly Technology Center, Indianapolis and/or Parkwood West. Permanent location at the new Lilly Medicines Foundry in Lebanon, Indiana. Limited domestic and international travel (

      Pay

      Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is $67,500 - $173,800. Full‑time equivalent employees also will be eligible for a company bonus