Member of Technical Staff, Translational Medicine

About the role

We're seeking a physician and medical expert to lead the clinical team at Latch. You will define the translational endpoints in our therapeutics and disease benchmarks and determine whether a model’s answer is correct to a treating physician, investigator, or regulator. You will also help obtain clinical data required to build these benchmarks. The most useful data is often not public—it sits within archived clinical trial records, patient registries, health systems, nonprofits, academic centers, and biotechnology companies. Access depends on trust, sound agreements, and a clear understanding of how sensitive data should be handled.

Responsibilities

• Define and own the translational endpoints used across our therapeutics and disease benchmarks. You will be expected to defend those decisions.
• Turn real drug programs and clinical-trial designs into tasks on which AI agents can be scored. Failed trials are especially useful when the reason for failure is known.
• Serve as the clinical authority for our omics, therapeutics, and biosecurity teams. Before Latch makes a clinical claim about a disease, you will be the final reviewer.
• Establish data partnerships with patient cohorts, nonprofits, health systems, academic centers, and biotechnology companies.
• Negotiate data-use agreements and build the consent, de-identification, compliance, and review processes required to work with clinically sensitive data.
• Build the clinical function at Latch, beginning with advisors and eventually hiring and building a team.

Requirements

• You hold an MD and have completed residency.
• You have defined or defended a clinical endpoint in a Phase I, Phase II, or Phase III clinical trial.
• You have served as a physician or named investigator on at least one Phase I, II, or III clinical trial. You can explain the molecule, patient population, dose rationale, safety profile, endpoint selection, and the responses from the FDA or safety monitoring board.
• You have authored FDA regulatory documents such as IND, clinical trial protocols, investigator brochure, BLA/sBLA filings, and medical device authorizations.
• You have a working command of disease development and can reason from a phenotype to its possible molecular or genetic basis.

Preferred Qualifications

• Experience in rare disease, oncology, solid tumors, or gene therapies.
• Familiarity with frontier AI model performance benchmarks.
• You have taken data-use agreements through execution yourself. You understand consent, de-identification, and IRB review well enough to design the process.
• You have secured a data or research partnership with a patient group, nonprofit, academic center, health system, or biotechnology company.
• Familiarity with HIPAA, GDPR, and NIH controlled-access systems, including dbGaP and Data Access Committees.
• Regular use of AI tools in clinical or scientific work, along with specific views about where those tools fail.

Location

This is a full-time, in-person position at our waterfront office in China Basin, San Francisco. The team works in the office five days a week during standard working hours.

Pay

Total compensation ranges from $250,000 to $400,000, depending on clinical and technical experience.

Benefits

• Long-term incentive plans, including equity and 401(k) contributions.
• Blue Shield Platinum health plan with 100% of premiums covered, no deductible, and no out-of-pocket costs.
• Daily meals, including lunch and dinner, provided.
• Travel and accommodations for medical conferences or other professional networking trips.