Mechanical & Hardware Engineer

iORGANBIO Durham, NC Company Overview We are building the technology and industrial base to make the promise of cell-based regenerative medicine available to everyone, for every ailment. We are a cutting-edge seed-stage biotechnology company building an AI-agentic deep tech platform to provide an infinite supply of unique functional tissues to enable transformative therapeutic solutions — at population scale. The platform seamlessly integrates software, AI, sequencing, and robotic solutions to listen to cells and adjust key parameters to guide stem cell differentiation. With a lean team of dedicated scientists and engineers, we are seeking a highly skilled Mechanical & Hardware Engineer to develop, optimize, and scale the intelligent hardware systems powering our tissue engineering platform. Position Overview The Mechanical & Hardware Engineer will design, prototype, and integrate mechanical and electromechanical systems that bridge biology, robotics, and automation. This is an on-site (Morrisville), paid, full-time initial 3-month contract position with the option to transition into a permanent role based on funding availability, performance, and mutual fit. Ideally, the candidate ends up building the hardware engineering department of the company. You will collaborate closely with leadership, biologists, software developers, AI scientists, and operations staff to build precision systems that enable tissue generation at scale. The objective of the first contract is to iterate twice on the core platform of the company to establish a first prototype that meets key performance objectives in support of the long-term vision of the company. Reports directly to the CEO. As an early member of a deep tech start-up led by biotech entrepreneurs with hyper-growth mentality, you will work closely with senior leadership and experience the early days of a start-up: autonomy, trust, and extremely high pace. Key ResponsibilitiesSystem Design & Integration Design, prototype, and iterate mechanical and electromechanical subsystems for tissue fabrication platforms (e.g., automated bioreactors, robotic handling, perfusion systems)Own the mechanical architecture of the platform: structures, enclosures, fixtures, fluid routing, and thermal managementIntegrate sensors, actuators, controllers, and off-the-shelf embedded systems into custom hardware platformsDevelop control code to run differentiation campaigns; develop APIs and UIs if neededDevelop scalable automation solutions for cell culture, differentiation, and tissue maturationCollaborate with software engineers to implement closed-loop control systems, machine vision, and real-time monitoring Hardware Development & Testing Build and maintain precision instrumentation that enables high-reliability tissue engineering workflowsConduct rapid prototyping using 3D printing, machining, CNC, and other fabrication methodsEvaluate system performance, run failure analysis, and optimize for robustness, accuracy, and throughputMaintain design documentation (CAD, schematics, wiring diagrams, BOMs) and ensure reproducibilityRun troubleshooting campaigns with water to discover and fix bugs across the stackRun beta experiments with live cells to demonstrate fitness of hardware for scientific and commercial applications; in collaboration with scientists Cross-functional Collaboration Work closely with cell biologists and bioengineers to align mechanical and biological performance targetsSupport scientific experimentation by rapidly iterating on hardware needsContribute to design reviews, safety assessments, and regulatory documentation as neededProvide training and technical support to lab and operations staffCommunicate actively with leadership about technical, cultural, and any other corporate topics Strategic Development Contribute to platform roadmap and inform long-term hardware infrastructure strategyIdentify and evaluate emerging technologies that could accelerate our manufacturing capabilitiesParticipate in IP generation and protect novel designs through coordination with legal counsel Required QualificationsTechnical Experience 2+ years in mechanical, hardware, or electromechanical engineering roles, ideally in industrial biotech, medical devices, or advanced manufacturing — personal projects or academic extra-curricular experiences are acceptableProficiency in 3D CAD (SolidWorks or other), design for manufacturing, and hardware development toolsHands-on experience with mechanical fabrication, assembly, and hardware bring-upFamiliarity with embedded systems (Raspberry Pi or others), control concepts, and automation platforms (e.g., PLCs, robotic arms, motion control systems) Domain Knowledge Understanding of biological lab workflows and constraints preferredExperience with fluidics, thermal management, and sterile design is a strong plusKnowledge of rapid prototyping and low-volume manufacturing methods Collaborative & Leadership Skills Comfortable working across disciplines in a small, dynamic teamStrong problem-solving and hands-on engineering abilitiesAbility to manage time effectively in a resource-constrained environmentExcellent written and verbal communication skills Preferred QualificationsEducational Background BS, MS, or PhD in Mechanical Engineering, Mechatronics, Robotics, Electrical Engineering, or related discipline Specific Experience Prior work in a startup, biotech startup, or medical hardware developmentExperience with FDA or ISO 13485 design control processesDemonstrated ability to take hardware from concept to functional deploymentParticipation in engineering forums, competitions, or open-source contributions What We OfferCompetitive Compensation Package, including cash, bonus, and equityProfessional Opportunity Own major technology components and complex hardware systemsGround-floor opportunity to shape the intelligent hardware backbone of a breakthrough biotech platformWork at the intersection of AI, software, sequencing, automation, and regenerative medicineDeep collaboration with a world-class scientific and engineering teamBuild a hyper growth start-up from the ground up Growth Environment Entrepreneurial, fast-paced environment with significant autonomyDirect reporting to the CEO and close collaboration with the scientific co-foundersOpportunity to build a core hardware function from the ground upExposure to leading-edge iPSC technology and regenerative therapeuticsSeniority level Entry level Employment type Full-time Job function Management and Manufacturing Industries Biotechnology Research Position Overview The Mechanical & Hardware Engineer will design, prototype, and integrate mechanical and electromechanical systems that bridge biology, robotics, and automation. This is an on-site (Morrisville), paid, full-time initial 3-month contract position with the option to transition into a permanent role based on funding availability, performance, and mutual fit. Ideally, the candidate ends up building the hardware engineering department of the company. You will collaborate closely with leadership, biologists, software developers, AI scientists, and operations staff to build precision systems that enable tissue generation at scale. The objective of the first contract is to iterate twice on the core platform of the company to establish a first prototype that meets key performance objectives in support of the long-term vision of the company. Reports directly to the CEO. As an early member of a deep tech start-up led by biotech entrepreneurs with hyper-growth mentality, you will work closely with senior leadership and experience the early days of a start-up: autonomy, trust, and extremely high pace. Key ResponsibilitiesSystem Design & Integration Design, prototype, and iterate mechanical and electromechanical subsystems for tissue fabrication platforms (e.g., automated bioreactors, robotic handling, perfusion systems)Own the mechanical architecture of the platform: structures, enclosures, fixtures, fluid routing, and thermal managementIntegrate sensors, actuators, controllers, and off-the-shelf embedded systems into custom hardware platformsDevelop control code to run differentiation campaigns; develop APIs and UIs if neededDevelop scalable automation solutions for cell culture, differentiation, and tissue maturationCollaborate with software engineers to implement closed-loop control systems, machine vision, and real-time monitoring Hardware Development & Testing Build and maintain precision instrumentation that enables high-reliability tissue engineering workflowsConduct rapid prototyping using 3D printing, machining, CNC, and other fabrication methodsEvaluate system performance, run failure analysis, and optimize for robustness, accuracy, and throughputMaintain design documentation (CAD, schematics, wiring diagrams, BOMs) and ensure reproducibilityRun troubleshooting campaigns with water to discover and fix bugs across the stackRun beta experiments with live cells to demonstrate fitness of hardware for scientific and commercial applications; in collaboration with scientists Cross-functional Collaboration Work closely with cell biologists and bioengineers to align mechanical and biological performance targetsSupport scientific experimentation by rapidly iterating on hardware needsContribute to design reviews, safety assessments, and regulatory documentation as neededProvide training and technical support to lab and operations staffCommunicate actively with leadership about technical, cultural, and any other corporate topics Strategic Development Contribute to platform roadmap and inform long-term hardware infrastructure strategyIdentify and evaluate emerging technologies that could accelerate our manufacturing capabilitiesParticipate in IP generation and protect novel designs through coordination with legal counsel Required QualificationsTechnical Experience 2+ years in mechanical, hardware, or electromechanical engineering roles, ideally in industrial biotech, medical devices, or advanced manufacturing — personal projects or academic extra-curricular experiences are acceptableProficiency in 3D CAD (SolidWorks or other), design for manufacturing, and hardware development toolsHands-on experience with mechanical fabrication, assembly, and hardware bring-upFamiliarity with embedded systems (Raspberry Pi or others), control concepts, and automation platforms (e.g., PLCs, robotic arms, motion control systems) Domain Knowledge Understanding of biological lab workflows and constraints preferredExperience with fluidics, thermal management, and sterile design is a strong plusKnowledge of rapid prototyping and low-volume manufacturing methods Collaborative & Leadership Skills Comfortable working across disciplines in a small, dynamic teamStrong problem-solving and hands-on engineering abilitiesAbility to manage time effectively in a resource-constrained environmentExcellent written and verbal communication skills Preferred QualificationsEducational Background BS, MS, or PhD in Mechanical Engineering, Mechatronics, Robotics, Electrical Engineering, or related discipline Specific Experience Prior work in a startup, biotech startup, or medical hardware developmentExperience with FDA or ISO 13485 design control processesDemonstrated ability to take hardware from concept to functional deploymentParticipation in engineering forums, competitions, or open-source contributions What We OfferCompetitive Compensation Package, including cash, bonus, and equityProfessional Opportunity Own major technology components and complex hardware systemsGround-floor opportunity to shape the intelligent hardware backbone of a breakthrough biotech platformWork at the intersection of AI, software, sequencing, automation, and regenerative medicineDeep collaboration with a world-class scientific and engineering teamBuild a hyper growth start-up from the ground up Growth Environment Entrepreneurial, fast-paced environment with significant autonomyDirect reporting to the CEO and close collaboration with the scientific co-foundersOpportunity to build a core hardware function from the ground upExposure to leading-edge iPSC technology and regenerative therapeuticsSeniority level Entry level Employment type Full-time Job function Management and Manufacturing Industries Biotechnology Research Position Overview The Mechanical & Hardware Engineer will design, prototype, and integrate mechanical and electromechanical systems that bridge biology, robotics, and automation. This is an on-site (Morrisville), paid, full-time initial 3-month contract position with the option to transition into a permanent role based on funding availability, performance, and mutual fit. Ideally, the candidate ends up building the hardware engineering department of the company. You will collaborate closely with leadership, biologists, software developers, AI scientists, and operations staff to build precision systems that enable tissue generation at scale. The objective of the first contract is to iterate twice on the core platform of the company to establish a first prototype that meets key performance objectives in support of the long-term vision of the company. Reports directly to the CEO. As an early member of a deep tech start-up led by biotech entrepreneurs with hyper-growth mentality, you will work closely with senior leadership and experience the early days of a start-up: autonomy, trust, and extremely high pace. Key ResponsibilitiesSystem Design & Integration Design, prototype, and iterate mechanical and electromechanical subsystems for tissue fabrication platforms (e.g., automated bioreactors, robotic handling, perfusion systems)Own the mechanical architecture of the platform: structures, enclosures, fixtures, fluid routing, and thermal managementIntegrate sensors, actuators, controllers, and off-the-shelf embedded systems into custom hardware platformsDevelop control code to run differentiation campaigns; develop APIs and UIs if neededDevelop scalable automation solutions for cell culture, differentiation, and tissue maturationCollaborate with software engineers to implement closed-loop control systems, machine vision, and real-time monitoring Hardware Development & Testing Build and maintain precision instrumentation that enables high-reliability tissue engineering workflowsConduct rapid prototyping using 3D printing, machining, CNC, and other fabrication methodsEvaluate system performance, run failure analysis, and optimize for robustness, accuracy, and throughputMaintain design documentation (CAD, schematics, wiring diagrams, BOMs) and ensure reproducibilityRun troubleshooting campaigns with water to discover and fix bugs across the stackRun beta experiments with live cells to demonstrate fitness of hardware for scientific and commercial applications; in collaboration with scientists Cross-functional Collaboration Work closely with cell biologists and bioengineers to align mechanical and biological performance targetsSupport scientific experimentation by rapidly iterating on hardware needsContribute to design reviews, safety assessments, and regulatory documentation as neededProvide training and technical support to lab and operations staffCommunicate actively with leadership about technical, cultural, and any other corporate topics Strategic Development Contribute to platform roadmap and inform long-term hardware infrastructure strategyIdentify and evaluate emerging technologies that could accelerate our manufacturing capabilitiesParticipate in IP generation and protect novel designs through coordination with legal counsel Required QualificationsTechnical Experience 2+ years in mechanical, hardware, or electromechanical engineering roles, ideally in industrial biotech, medical devices, or advanced manufacturing — personal projects or academic extra-curricular experiences are acceptableProficiency in 3D CAD (SolidWorks or other), design for manufacturing, and hardware development toolsHands-on experience with mechanical fabrication, assembly, and hardware bring-upFamiliarity with embedded systems (Raspberry Pi or others), control concepts, and automation platforms (e.g., PLCs, robotic arms, motion control systems) Domain Knowledge Understanding of biological lab workflows and constraints preferredExperience with fluidics, thermal management, and sterile design is a strong plusKnowledge of rapid prototyping and low-volume manufacturing methods Collaborative & Leadership Skills Comfortable working across disciplines in a small, dynamic teamStrong problem-solving and hands-on engineering abilitiesAbility to manage time effectively in a resource-constrained environmentExcellent written and verbal communication skills Preferred QualificationsEducational Background BS, MS, or PhD in Mechanical Engineering, Mechatronics, Robotics, Electrical Engineering, or related discipline Specific Experience Prior work in a startup, biotech startup, or medical hardware developmentExperience with FDA or ISO 13485 design control processesDemonstrated ability to take hardware from concept to functional deploymentParticipation in engineering forums, competitions, or open-source contributions What We OfferCompetitive Compensation Package, including cash, bonus, and equityProfessional Opportunity Own major technology components and complex hardware systemsGround-floor opportunity to shape the intelligent hardware backbone of a breakthrough biotech platformWork at the intersection of AI, software, sequencing, automation, and regenerative medicineDeep collaboration with a world-class scientific and engineering teamBuild a hyper growth start-up from the ground up Growth Environment Entrepreneurial, fast-paced environment with significant autonomyDirect reporting to the CEO and close collaboration with the scientific co-foundersOpportunity to build a core hardware function from the ground upExposure to leading-edge iPSC technology and regenerative therapeutics Referrals increase your chances of interviewing at iORGANBIO by 2x See who you know Hardware Engineer Hardware Engineer Cisco Triangle, NC 4 days ago Product Engineer Product Engineer Analog Devices Durham, NC 2 weeks ago R&D Engineer - 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