Manager, Manufacturing

About the role

At Bristol Myers Squibb, employees are driven by a purpose‑focused culture that inspires discovery, development, and delivery of innovative medicines. The company offers meaningful work, growth opportunities, and a supportive environment that values inclusion, wellbeing, flexibility, and comprehensive benefits.

Position Summary

The Manufacturing Manager I leads execution of manufacturing processes for cell therapies under Current Good Manufacturing Practices (cGMP). The role oversees a team focused on process execution, technical assessment, safety, compliance, and innovation, providing troubleshooting, investigation support, data analysis, and process improvement.

Responsibilities

• Manage creation, implementation, and compliance of all Source Governing Documents (SOPs, Work Instructions, Batch Records, Forms) for cell therapy operations.
• Oversee operations within validated manufacturing systems, planning and assigning resources while controlling costs.
• Maintain operating and storage areas to be compliant, efficient, safe, and inspection‑ready.
• Drive right‑first‑time initiatives, hold the team accountable for compliance, and generate solutions for compliance issues.
• Prepare, align, and implement Change Controls; complete MRB slides and present at MRB meetings as needed.
• Initiate change controls, notices of events, deviations, and investigations; drive actions to closure.
• Evaluate team performance and continuously improve cost, quality, safety, culture, and delivery.
• Identify strategic and operational issues to prevent deviations and maintain a compliant environment.
• Lead development of corrective and preventative actions, deviation responses, and investigations.
• Verify manufacturing associates and team leads are fully trained on GxP curricula before performing any GxP task.
• Foster teamwork, open communication, urgency, and a culture of safety—including psychological safety and patient safety.
• Coordinate and communicate Operations project information and status to Planning, Manufacturing, QA/Operations, Global Supply, and other functions.
• Participate in facility walk‑throughs, process troubleshooting, event triage, and provide timely coaching to manufacturing personnel.
• Oversee operators performing unit and support operations described in Source Governing Documents in a safe, GMP‑compliant manner.
• Complete documentation contemporaneously as required by Source Governing Documents.
• Maintain training compliance by completing all training assignments to ensure necessary technical skills and knowledge.
• Assist in setup of manufacturing areas, equipment/fixtures, facility and equipment commissioning, and qualification/validation activities.
• Write manufacturing operating procedures that are technically sound, efficient, and cGMP‑compliant.
• Hire, mentor, and develop staff; conduct performance reviews, address performance issues, and identify career growth opportunities.

Qualifications

• Bachelor’s degree in a relevant science or engineering discipline, or equivalent work experience.
• 5+ years of experience in cGMP cell therapy manufacturing, bioprocessing manufacturing, or related field.
• 2+ years of leadership experience (lead or equivalent) with performance‑management responsibilities (highly desirable).
• Highly preferred experience in:
  • Cell therapy manufacturing
  • Aseptic processing in ISO 5 biosafety cabinets and universal precautions for human‑derived materials in BSL‑2/ML‑1 containment
  • Cell expansion using incubators and single‑use bioreactors
  • Cell washing, separation, and cryopreservation processes and equipment

Working Conditions

• Extended periods of standing/walking.
• Cleanroom environment with aseptic processing in ISO 5 biosafety cabinets; required gowning and PPE (safety shoes, glasses, aprons, face shield, PAPR, lab coat, gown, hairnet, gloves, hearing protection).
• Ability to lift/carry up to 30 lb (15 kg) several times daily and push/pull up to 50 lb (25 kg) several times daily.
• Exposure to strong magnets and vapor‑phase liquid nitrogen.
• Work in BSL‑2/ML‑1 environment handling human blood components.
• Must be able to work assigned shifts, including days, evenings, nights, weekends, and holidays.

Shift Options

• Days – Sun – Tue (alt. Wed) 05:00‑17:30
• Days – Thu – Sat (alt. Wed) 05:00‑17:30
• Swing – Sun – Tue (alt. Wed) 11:00‑23:30
• Swing – Thu – Sat (alt. Wed) 11:00‑23:30
• Nights – Sun – Wed (alt. Sat) 17:00‑05:30
• Nights – Wed – Fri (alt. Sat) 17:00‑05:30

Compensation Overview

Bothell, WA – $113,930 – $138,051 base salary for full‑time employees. Additional discretionary incentive cash and stock opportunities may be available. Pay is determined based on role, skills, location, schedule, and experience, following pay‑equity principles and applicable laws.

Benefits

• Comprehensive benefit plans including medical, dental, vision, life, disability, retirement, and financial protection.
• Flexible Time Off (FTO) for U.S. exempt employees (no set accrual limit) plus 11 paid company holidays.
• Non‑exempt, RayzeBio, and Puerto Rico employees receive 160 hours of paid vacation annually, 11 paid holidays, and 3 optional holidays.
• Additional time‑off options: paid sick leave, up to two paid volunteer days per year, summer‑hours flexibility, and various leaves of absence (medical, parental, caregiver, bereavement, military, etc.).
• Annual Global Shutdown between Christmas Day and New Year’s Day.