Immunology Senior Research Scientist - Single-Cell Genomics

About the role

The successful candidate will lead the design, execution, optimization, and interpretation of single-cell genomics and multi-omics workflows, with a primary emphasis on wet-lab experimental biology. This role will focus on implementation of 10x Genomics-based and related single-cell platforms to generate high-quality datasets from complex tissue and peripheral biological samples, including applications in immune cell profiling and disease-relevant contexts.

Responsibilities

• Execute Single-Cell Genomics and Multi-Omics Workflows
• Process primary samples and cell-based systems for single-cell applications, including tissue dissociation, cell isolation, enrichment, counting, and viability assessment
• Generate high-quality libraries for transcriptomic, epigenomic, and/or immune profiling applications
• Perform sample and library QC using standard methods such as Qubit, TapeStation, and Bioanalyzer
• Establish and refine SOPs, assay documentation, and experimental best practices
• Workflow Optimization and Troubleshooting
• Execute and troubleshoot assays using 10x Chromium and related technologies
• Troubleshoot technical issues across the workflow, including sample quality, library complexity, and sequencing performance
• Optimize workflows as needed to maximize sample quality, cell recovery, and reproducibility across studies
• Benchmark new methods and contribute to adoption of next-generation single-cell and multiomics capabilities
• Coordination and Cross-Functional Collaboration
• Coordinate with internal core groups or external vendors for sequencing, run tracking, and data generation
• Support or interface with flow cytometry and cell sorting activities where needed to enable downstream genomics workflows
• Collaborate closely with bioinformatics and computational biology teams to support interpretation of complex datasets and enable biologically meaningful insights
• Perform critical evaluation of assay and sequencing metrics, including read depth, mapping performance, cell recovery, and QC thresholds

Knowledge and Skills

• Deep hands-on expertise in single-cell genomics workflows, with particular experience in 10x Genomics platforms
• Strong wet-lab background in NGS library preparation, molecular biology, and complex sample processing
• Demonstrated ability to independently design, execute, troubleshoot, and optimize technically sophisticated experiments
• Experience with downstream computational analysis of single-cell datasets is not required but would be considered a significant advantage
• Strong attention to detail and commitment to high standards in experimental rigor, data quality, and documentation
• Effective communicator and collaborative scientist who works well in multidisciplinary, matrixed research environments

Education and Experience

• PhD in Genomics, Molecular Biology, Chemical Engineering, Bioengineering, or a related discipline with 2+ years of relevant experience; or Master’s degree with 6+ years of relevant experience; or Bachelor’s degree with 8+ years of relevant experience

Benefits

Vertex offers a competitive compensation package, including a range of $124,200 - $186,400, an annual bonus, and annual equity awards. Additional benefits include inclusive market-leading benefits, flexible working arrangements, and a supportive work environment.