Head of Translational Medicine
BioSpace · Cambridge, MA · 1 mo ago
Healthcare$272k–$490k/yrFull-time
We need to output HTML fragment with sections: h3 headings for sections present: About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. We must include only sections with real specific content. The posting includes: "The Role" description (overview), then "Here’s What You’ll Do" (responsibilities), then "Here’s What You’ll Need (Minimum Qualifications)" (requirements/qualifications), then "Here’s What You’ll Bring to the Table (Preferred Qualifications)" (maybe skills?), then "Pay & Benefits" includes benefits and salary range. Also "About Moderna" and "Our Working Model" etc but those are boilerplate? The instruction: remove cookie/navigation/legal/EEO/equal-opportunity/scam-warning boilerplate, duplicated lines, and application instructions. Also remove sections like "About Moderna", "Our Working Model", "Equal Opportunities", "Accommodations", "Export Control Notice". So we keep only substantive content: role description, responsibilities, minimum qualifications, preferred qualifications, pay and benefits.
We need headings: Use for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). We need to decide which headings to use. The posting has: "The Role" (maybe About the role). Then "Here’s What You’ll Do" (Responsibilities). Then "Here’s What You’ll Need (Minimum Qualifications)" (Requirements/Qualifications). Then "Here’s What You’ll Bring to the Table (Preferred Qualifications)" (Skills maybe). Then "Pay & Benefits" (Pay and Benefits). No schedule info. So we will not include Schedule heading.
We must not repeat job title as heading. The page already shows it, so we don't add a heading for "Head of Translational Medicine". Good.
We need to use
for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). We need to decide which headings to use. The posting has: "The Role" (maybe About the role). Then "Here’s What You’ll Do" (Responsibilities). Then "Here’s What You’ll Need (Minimum Qualifications)" (Requirements/Qualifications). Then "Here’s What You’ll Bring to the Table (Preferred Qualifications)" (Skills maybe). Then "Pay & Benefits" (Pay and Benefits). No schedule info. So we will not include Schedule heading.
We must not repeat job title as heading. The page already shows it, so we don't add a heading for "Head of Translational Medicine". Good.
We need to use - for any list of duties/requirements/benefits, and
for prose.
We need to preserve all substantive information, not invent or summarize away detail. So we need to keep the details from each section.
We need to format as HTML fragment only.
Let's extract content.
Section: About the role (maybe heading
About the role
). Content: The paragraph starting "The Role Moderna is seeking an enterprise-minded Head of Translational Medicine to lead and integrate translational medicine, translational research, and clinical pharmacology & pharmacometrics into a unified, high-impact organization. This role will define and execute a cohesive translational strategy across the full lifecycle of Moderna’s oncology and therapeutics pipeline—from discovery through clinical development and lifecycle management. The Head of Translational Medicine will ensure seamless integration of biological insights, biomarker strategies, quantitative pharmacology, and clinical translation to accelerate decision-making, optimize development pathways, and maximize the probability of technical and regulatory success. This is a senior leadership role at the core of Moderna’s ability to translate its mRNA platform into transformative medicines. As a key member of the Development leadership team, this individual will unify translational disciplines to drive innovation at the intersection of Research and Development, shaping how the company makes development decisions, accelerates programs, and delivers differentiated medicines for patients at scale, while leading a large, multidisciplinary organization."
We need to put that in .
Section: Responsibilities (
Responsibilities
). Content: "Here’s What You’ll Do" bullet points. The text includes several paragraphs each starting with a bold heading? Actually the text:
"Here’s What You’ll Do Enterprise & Portfolio Strategy Define and lead an integrated, end-to-end translational strategy across Translational Medicine, Translational Research, and Clinical Pharmacology/Pharmacometrics, spanning discovery through lifecycle managementEstablish a unified framework connecting biological insights, biomarkers, and quantitative pharmacology to enable rapid, data-driven decision-makingEnsure alignment of translational strategies with overall program and portfolio objectives, including development pathways, target product profiles, and regulatory strategiesLead translational input into governance, ensuring rigorous, data-driven go/no-go decisions across the pipeline Organizational & Scientific Leadership Lead and unify a high-performing, multidisciplinary translational organization, connecting scientific, clinical, and quantitative capabilities into a cohesive, highly integrated modelServe as a senior leader and thought partner across Research and Development, influencing strategy, prioritization, and executionRepresent Moderna’s translational strategy externally, engaging regulators, scientific leaders, and partners to shape scientific direction and advance best-in-class approaches across the portfolio Translational Medicine Lead execution of early clinical translational plans, including biomarker implementation, endpoint operationalization, and data interpretation to enable clear proof-of-concept decisionsPartner with clinical development to translate scientific hypotheses into actionable clinical strategies and high-quality study executionDefine and validate novel endpoints and patient stratification approaches to enable early decision-making and differentiationServe as a senior clinical leader in internal and external settings, including study teams, governance, and interactions with investigators and key opinion leaders Translational Research Build and advance differentiated translational capabilities (e.g., molecular assays, sequencing, immune monitoring, CDx) to enable patient selection and mechanistic insightOversee generation and delivery of stage-appropriate translational data packages to support IND readiness and early clinical developmentDrive forward and reverse translation, ensuring clinical insights inform discovery, platform innovation, and next-generation therapeuticsLead development of patient identification, pharmacodynamic, and disease monitoring strategies to support clinical entry and advancement Clinical Pharmacology & Pharmacometrics Drive quantitative integration of PK/PD, exposure-response, and modeling & simulation into program-level decision-making and trial designLead pharmacology contributions to regulatory strategy, including authorship and defense of clinical pharmacology components in health authority interactionsEnsure innovative application of pharmacometrics to dose prediction, first-in-human studies, and lifecycle optimization across the pipelineRepresent clinical pharmacology in governance and partner cross-functionally to inform critical dose and development decisions across programs"
We need to turn these into list items. Probably each bold heading is a subsection; we can make each bullet as a list item containing the sentences. Could also break into multiple list items per bullet. The instruction: use - for any list of duties/requirements/benefits. So we should make a
with - items for each duty. We'll parse the responsibilities into logical items.
Let's identify items:
- Enterprise & Portfolio Strategy:
* Define and lead an integrated, end-to-end translational strategy across Translational Medicine, Translational Research, and Clinical Pharmacology/Pharmacometrics, spanning discovery through lifecycle management
* Establish a unified framework connecting biological insights, biomarkers, and quantitative pharmacology to enable rapid, data-driven decision-making
* Ensure alignment of translational strategies with overall program and portfolio objectives, including development pathways, target product profiles, and regulatory strategies
* Lead translational input into governance, ensuring rigorous, data-driven go/no-go decisions across the pipeline
- Organizational & Scientific Leadership:
* Lead and unify a high-performing, multidisciplinary translational organization, connecting scientific, clinical, and quantitative capabilities into a cohesive, highly integrated model
* Serve as a senior leader and thought partner across Research and Development, influencing strategy, prioritization, and execution
* Represent Moderna’s translational strategy externally, engaging regulators, scientific leaders, and partners to shape scientific direction and advance best-in-class approaches across the portfolio
- Translational Medicine:
* Lead execution of early clinical translational plans, including biomarker implementation, endpoint operationalization, and data interpretation to enable clear proof-of-concept decisions
* Partner with clinical development to translate scientific hypotheses into actionable clinical strategies and high-quality study execution
* Define and validate novel endpoints and patient stratification approaches to enable early decision-making and differentiation
* Serve as a senior clinical leader in internal and external settings, including study teams, governance, and interactions with investigators and key opinion leaders
- Translational Research:
* Build and advance differentiated translational capabilities (e.g., molecular assays, sequencing, immune monitoring, CDx) to enable patient selection and mechanistic insight
* Oversee generation and delivery of stage-appropriate translational data packages to support IND readiness and early clinical development
* Drive forward and reverse translation, ensuring clinical insights inform discovery, platform innovation, and next-generation therapeutics
* Lead development of patient identification, pharmacodynamic, and disease monitoring strategies to support clinical entry and advancement
- Clinical Pharmacology & Pharmacometrics:
* Drive quantitative integration of PK/PD, exposure-response, and modeling & simulation into program-level decision-making and trial design
* Lead pharmacology contributions to regulatory strategy, including authorship and defense of clinical pharmacology components in health authority interactions
* Ensure innovative application of pharmacometrics to dose prediction, first-in-human studies, and lifecycle optimization across the pipeline
* Represent clinical pharmacology in governance and partner cross-functionally to inform critical dose and development decisions across programs
We'll put each as
- .
Section: Requirements / Qualifications (
Requirements
maybe). The posting has "Here’s What You’ll Need (Minimum Qualifications)". We'll treat as Requirements. Content list:
- Advanced degree (PhD, MD, PharmD, or equivalent) in a relevant scientific discipline
- 15+ years of experience across translational science, clinical pharmacology, and/or drug development, with at least 10 years in a leadership role
- Deep expertise spanning translational medicine, biomarker strategy, experimental medicine, and quantitative pharmacology
- Demonstrated ability to develop scientific hypotheses on human disease and translate this between the clinic and the laboratory
- Demonstrated success influencing development strategy, including dose selection, study design, and regulatory interactions
- Strong understanding of the end-to-end drug development process, from discovery through commercialization
- Strong publication record and ability to represent Moderna externally to scientific community
- Proven ability to lead large, multidisciplinary teams and operate effectively in a complex matrix environment.
- Experience mentor, hiring, and growing talented scientists (maybe grammar: "Experience mentor, hiring, and growing talented scientists" likely means experience mentoring, hiring, and growing talented scientists)
- Track record of driving innovation and delivering measurable impact across a portfolio
- Exceptional communication and influencing skills, with the ability to translate complex science into strategic decisions
We'll put each as - .
Section: Preferred Qualifications (
Skills
maybe). The posting: "Here’s What You’ll Bring to the Table (Preferred Qualifications): Experience with companion diagnosticsLeadership roles contributing to BLAs for oncology or immunology programsDeep expertise in immunology, oncology and autoimmune diseaseNetwork of external academic experts". We need to separate items. Likely each phrase separated by missing punctuation. We'll parse:
- Experience with companion diagnostics
- Leadership roles contributing to BLAs for oncology or immunology programs
- Deep expertise in immunology, oncology and autoimmune disease
- Network of external academic experts
We'll put as - under Skills heading.
Section: Pay & Benefits (
Pay
and Benefits
maybe separate). The posting includes both Pay and Benefits. We have salary range and description of benefits. We could combine into one section "Pay & Benefits" but headings list includes Pay and Benefits separate. We could make two headings: Pay and Benefits. However instruction: "Prefer a few substantive sections over many thin ones." Could combine into one heading "Pay & Benefits". But they gave examples of headings including Pay, Benefits, Schedule. It says use for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). It doesn't forbid combining but we could follow the examples. However they say "include a section ONLY when the posting has real, specific content for it". The posting has both pay and benefits content. We could make two sections: Pay and Benefits. That's fine.
Pay: salary range $272,200.00 - $490,100.00 plus description about discretionary bonus, other incentive compensation, equity award. We'll put that in
under
Pay
.
Benefits: list of benefits: Best-in-class healthcare coverage, plus voluntary benefit programs to support your unique needs; A holistic approach to well-being, with access to fitness, mindfulness, and mental health support; Family planning benefits, including fertility, adoption, and surrogacy support; Generous paid time off, including vacation, volunteer days, sabbat
for prose. We need to preserve all substantive information, not invent or summarize away detail. So we need to keep the details from each section. We need to format as HTML fragment only. Let's extract content. Section: About the role (maybe heading
About the role
). Content: The paragraph starting "The Role Moderna is seeking an enterprise-minded Head of Translational Medicine to lead and integrate translational medicine, translational research, and clinical pharmacology & pharmacometrics into a unified, high-impact organization. This role will define and execute a cohesive translational strategy across the full lifecycle of Moderna’s oncology and therapeutics pipeline—from discovery through clinical development and lifecycle management. The Head of Translational Medicine will ensure seamless integration of biological insights, biomarker strategies, quantitative pharmacology, and clinical translation to accelerate decision-making, optimize development pathways, and maximize the probability of technical and regulatory success. This is a senior leadership role at the core of Moderna’s ability to translate its mRNA platform into transformative medicines. As a key member of the Development leadership team, this individual will unify translational disciplines to drive innovation at the intersection of Research and Development, shaping how the company makes development decisions, accelerates programs, and delivers differentiated medicines for patients at scale, while leading a large, multidisciplinary organization." We need to put that in. Section: Responsibilities (
Responsibilities
). Content: "Here’s What You’ll Do" bullet points. The text includes several paragraphs each starting with a bold heading? Actually the text: "Here’s What You’ll Do Enterprise & Portfolio Strategy Define and lead an integrated, end-to-end translational strategy across Translational Medicine, Translational Research, and Clinical Pharmacology/Pharmacometrics, spanning discovery through lifecycle managementEstablish a unified framework connecting biological insights, biomarkers, and quantitative pharmacology to enable rapid, data-driven decision-makingEnsure alignment of translational strategies with overall program and portfolio objectives, including development pathways, target product profiles, and regulatory strategiesLead translational input into governance, ensuring rigorous, data-driven go/no-go decisions across the pipeline Organizational & Scientific Leadership Lead and unify a high-performing, multidisciplinary translational organization, connecting scientific, clinical, and quantitative capabilities into a cohesive, highly integrated modelServe as a senior leader and thought partner across Research and Development, influencing strategy, prioritization, and executionRepresent Moderna’s translational strategy externally, engaging regulators, scientific leaders, and partners to shape scientific direction and advance best-in-class approaches across the portfolio Translational Medicine Lead execution of early clinical translational plans, including biomarker implementation, endpoint operationalization, and data interpretation to enable clear proof-of-concept decisionsPartner with clinical development to translate scientific hypotheses into actionable clinical strategies and high-quality study executionDefine and validate novel endpoints and patient stratification approaches to enable early decision-making and differentiationServe as a senior clinical leader in internal and external settings, including study teams, governance, and interactions with investigators and key opinion leaders Translational Research Build and advance differentiated translational capabilities (e.g., molecular assays, sequencing, immune monitoring, CDx) to enable patient selection and mechanistic insightOversee generation and delivery of stage-appropriate translational data packages to support IND readiness and early clinical developmentDrive forward and reverse translation, ensuring clinical insights inform discovery, platform innovation, and next-generation therapeuticsLead development of patient identification, pharmacodynamic, and disease monitoring strategies to support clinical entry and advancement Clinical Pharmacology & Pharmacometrics Drive quantitative integration of PK/PD, exposure-response, and modeling & simulation into program-level decision-making and trial designLead pharmacology contributions to regulatory strategy, including authorship and defense of clinical pharmacology components in health authority interactionsEnsure innovative application of pharmacometrics to dose prediction, first-in-human studies, and lifecycle optimization across the pipelineRepresent clinical pharmacology in governance and partner cross-functionally to inform critical dose and development decisions across programs" We need to turn these into list items. Probably each bold heading is a subsection; we can make each bullet as a list item containing the sentences. Could also break into multiple list items per bullet. The instruction: use- for any list of duties/requirements/benefits. So we should make a
- with
- items for each duty. We'll parse the responsibilities into logical items. Let's identify items: - Enterprise & Portfolio Strategy: * Define and lead an integrated, end-to-end translational strategy across Translational Medicine, Translational Research, and Clinical Pharmacology/Pharmacometrics, spanning discovery through lifecycle management * Establish a unified framework connecting biological insights, biomarkers, and quantitative pharmacology to enable rapid, data-driven decision-making * Ensure alignment of translational strategies with overall program and portfolio objectives, including development pathways, target product profiles, and regulatory strategies * Lead translational input into governance, ensuring rigorous, data-driven go/no-go decisions across the pipeline - Organizational & Scientific Leadership: * Lead and unify a high-performing, multidisciplinary translational organization, connecting scientific, clinical, and quantitative capabilities into a cohesive, highly integrated model * Serve as a senior leader and thought partner across Research and Development, influencing strategy, prioritization, and execution * Represent Moderna’s translational strategy externally, engaging regulators, scientific leaders, and partners to shape scientific direction and advance best-in-class approaches across the portfolio - Translational Medicine: * Lead execution of early clinical translational plans, including biomarker implementation, endpoint operationalization, and data interpretation to enable clear proof-of-concept decisions * Partner with clinical development to translate scientific hypotheses into actionable clinical strategies and high-quality study execution * Define and validate novel endpoints and patient stratification approaches to enable early decision-making and differentiation * Serve as a senior clinical leader in internal and external settings, including study teams, governance, and interactions with investigators and key opinion leaders - Translational Research: * Build and advance differentiated translational capabilities (e.g., molecular assays, sequencing, immune monitoring, CDx) to enable patient selection and mechanistic insight * Oversee generation and delivery of stage-appropriate translational data packages to support IND readiness and early clinical development * Drive forward and reverse translation, ensuring clinical insights inform discovery, platform innovation, and next-generation therapeutics * Lead development of patient identification, pharmacodynamic, and disease monitoring strategies to support clinical entry and advancement - Clinical Pharmacology & Pharmacometrics: * Drive quantitative integration of PK/PD, exposure-response, and modeling & simulation into program-level decision-making and trial design * Lead pharmacology contributions to regulatory strategy, including authorship and defense of clinical pharmacology components in health authority interactions * Ensure innovative application of pharmacometrics to dose prediction, first-in-human studies, and lifecycle optimization across the pipeline * Represent clinical pharmacology in governance and partner cross-functionally to inform critical dose and development decisions across programs We'll put each as
- .
Section: Requirements / Qualifications (
Requirements
maybe). The posting has "Here’s What You’ll Need (Minimum Qualifications)". We'll treat as Requirements. Content list: - Advanced degree (PhD, MD, PharmD, or equivalent) in a relevant scientific discipline - 15+ years of experience across translational science, clinical pharmacology, and/or drug development, with at least 10 years in a leadership role - Deep expertise spanning translational medicine, biomarker strategy, experimental medicine, and quantitative pharmacology - Demonstrated ability to develop scientific hypotheses on human disease and translate this between the clinic and the laboratory - Demonstrated success influencing development strategy, including dose selection, study design, and regulatory interactions - Strong understanding of the end-to-end drug development process, from discovery through commercialization - Strong publication record and ability to represent Moderna externally to scientific community - Proven ability to lead large, multidisciplinary teams and operate effectively in a complex matrix environment. - Experience mentor, hiring, and growing talented scientists (maybe grammar: "Experience mentor, hiring, and growing talented scientists" likely means experience mentoring, hiring, and growing talented scientists) - Track record of driving innovation and delivering measurable impact across a portfolio - Exceptional communication and influencing skills, with the ability to translate complex science into strategic decisions We'll put each as - .
Section: Preferred Qualifications (
Skills
maybe). The posting: "Here’s What You’ll Bring to the Table (Preferred Qualifications): Experience with companion diagnosticsLeadership roles contributing to BLAs for oncology or immunology programsDeep expertise in immunology, oncology and autoimmune diseaseNetwork of external academic experts". We need to separate items. Likely each phrase separated by missing punctuation. We'll parse: - Experience with companion diagnostics - Leadership roles contributing to BLAs for oncology or immunology programs - Deep expertise in immunology, oncology and autoimmune disease - Network of external academic experts We'll put as - under Skills heading.
Section: Pay & Benefits (
Pay
andBenefits
maybe separate). The posting includes both Pay and Benefits. We have salary range and description of benefits. We could combine into one section "Pay & Benefits" but headings list includes Pay and Benefits separate. We could make two headings: Pay and Benefits. However instruction: "Prefer a few substantive sections over many thin ones." Could combine into one heading "Pay & Benefits". But they gave examples of headings including Pay, Benefits, Schedule. It says usefor section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). It doesn't forbid combining but we could follow the examples. However they say "include a section ONLY when the posting has real, specific content for it". The posting has both pay and benefits content. We could make two sections: Pay and Benefits. That's fine. Pay: salary range $272,200.00 - $490,100.00 plus description about discretionary bonus, other incentive compensation, equity award. We'll put that in
under
Pay
. Benefits: list of benefits: Best-in-class healthcare coverage, plus voluntary benefit programs to support your unique needs; A holistic approach to well-being, with access to fitness, mindfulness, and mental health support; Family planning benefits, including fertility, adoption, and surrogacy support; Generous paid time off, including vacation, volunteer days, sabbat