Head of DMPK
About the role
The Opportunity At Recursion we are redefining drug discovery by uniting industrial-scale data generation with sophisticated computational models. We are seeking a visionary Head of DMPK to join our leadership team.
Responsibilities
Define and execute the overarching DMPK strategy for a diverse therapeutic area portfolio, primarily focused on small molecules with the agility to support emerging modalities (e.g. peptides, ADCs, proximity-inducing therapeutics).
Ensure high degree of scientific excellence as programs move from early discovery into development ensuring robust human dose projections, DDI assessments, and supporting translational PK/PD strategies.
Partner with Data Science and ML teams to refine our predictive ADME models, transforming how we prioritize compounds and de-risking the portfolio.
Act as a strategic subject matter expert for high-stakes external partnerships by collaborating with internal scientific leaders and external counterparts with transparency and technical rigor.
Develop and lead a high-performing team. You won't just manage - you will amplify the talents of your team, fostering an environment of active learning and rapid adaptation.
A critical component of multidisciplinary project teams. A critical partner to Toxicology, Translation and Design ensuring that DMPK insights are integrated into the earliest stages of target validation and lead optimization.
Requirements
You hold a PhD (or equivalent) in Pharmacokinetics, Drug Metabolism, Pharmacology, or a related field.
You have a proven track record of moving multiple programs from Discovery into Development (typically 15+ years) in the pharmaceutical or biotech industry.
You are comfortable working at the intersection of biology and technology. You are cautiously optimistic that data-driven, computational approaches are the future of drug discovery.
You have deep expertise in small molecule DMPK is essential. Experience with related modalities (ADCs, proximity-inducing or peptides) is a distinct advantage.
You are intimately familiar with IND submission requirements and have a history of successfully navigating regulatory interactions.
You value "One Team" over silos. You are known for strong, transparent working relationships and the ability to influence cross-functional stakeholders.
Qualifications
Expertise in in vitro & in vivo ADME as well as contemporary PK/PD modeling. Extending to the properties and data sets commensurate with CNS exposure (or conversely restricting exposure to peripheral tissues).
Experience with human PK and efficacious dose prediction.
Proficiency in managing CROs to ensure high-quality data and timely delivery.
Knowledge of biotransformation and metabolic pathways.
Extensive experience in working with external collaborators in all shapes and forms (CROs, SMEs, Large Pharma).
Skills
Nimble Mindset: You are comfortable working at the intersection of biology and technology. You are cautiously optimistic that data-driven, computational approaches are the future of drug discovery.
Modality Expert: Deep expertise in small molecule DMPK is essential. Experience with related modalities (ADCs, proximity-inducing or peptides) is a distinct advantage.
Regulatory Navigator: You are intimately familiar with IND submission requirements and have a history of successfully navigating regulatory interactions.
Collaborative Leader: You value "One Team" over silos. You are known for strong, transparent working relationships and the ability to influence cross-functional stakeholders.
Benefits
At Recursion, we believe that every employee should be compensated fairly. Based on the skills, experience, and qualifications needed for this role, the estimated annual base salary range is:
- New York City, Boston, & San Francisco Bay Area(s): $353,980–$443,080
- Salt Lake City & all other U.S. locations: $321,800–$402,800
In addition to base salary, this role is eligible for an annual bonus, equity compensation, and a comprehensive benefits package.
Pay
This is an office-based, hybrid position at any either of our offices located in Salt Lake City or New York City. Employees are expected to work in the office at least 50% of the time.
Schedule
Our team will communicate directly with candidates who are not represented by an agent or intermediary unless otherwise agreed to prior to interviewing for the job.