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Founder in Residence, Unlocking systemic drug delivery for brain & CNS disease

Deep Science Ventures · United States · 2 wk ago
RemoteRemoteDistribution$330k/yrFull-time

About the role

We are seeking entrepreneurially-minded scientists with deep technical expertise to lead a company that makes it fundamentally easier, safer, and more broadly applicable to get therapeutics into the brain. This role offers a unique opportunity to work at the forefront of CNS drug delivery.

Requirements

  • Essential - Technical Depth & Breadth: Deep expertise in at least two of the following four areas:

    • Protein Engineering: Experience leading protein engineering strategy, protein design, structural analysis, and sequence motif analysis;
    • Lead Generation Campaigns: Experience in Antibody lead generation (in silico or immunisation) & optimisation;
    • Biologics Drug Development: Experience across diverse modalities: bispecific antibodies, protein fusions, antibody conjugates, Fc engineering, synthetic proteins, macrocyclic peptides; Discovery & pre-clinical development (target ID, target validation, lead generation, lead optimisation, DC, IND); Developability (PK/PD, ADME, Toxicology, CMC); In vitro and in vivo pharmacology and study design for protein biologics;
    • Cell Biology & Neurobiology: Intracellular trafficking, endocytosis, adaptor proteins, endosomal sorting, tubule formation, kinesin transport; Blood-brain barrier biology, endothelial cell biology, transcytosis, receptor-mediated transcytosis (RMT), carrier-mediated transcytosis (CMT); CNS disease biology (AD, PD, MS, and other neurological conditions); Human BBB translational models (e.g. in vitro iPSC-derived BBB models).

  • Essential - Translational Execution: Record of translating scientific concepts from discovery through to in vivo proof-of-concept or IND;

  • You are highly motivated by unsolved challenges in CNS drug delivery, and driven to challenge the status quo of how we treat brain diseases;

  • You are impact driven, take the initiative, make things happen, and can think from a first principles perspective to figure out what's really needed;

  • You have clear entrepreneurial spirit and mindset, demonstrated through impactful innovation, and an ability to work in ambiguous, unstructured but fast-paced, demanding and pressurised environments;

  • Collaborative nature, with the ability to work effectively in cross-functional teams.

Qualifications

Nice to have:

  • CNS preclinical or clinical drug development experience;
  • Single-cell transcriptomic data analysis;
  • Target & biomarker identification;
  • Deep understanding of IP - FTO and patentability, with a track record of patents in this field;
  • Track record of publications and/or thought leadership in CNS delivery or related fields;
  • Previous biotech founder or C-suite leadership experience;
  • Previous fundraising experience (VC, dilutive or non-dilutive);
  • Experience building and leading successful scientific or cross-functional teams;
  • Network across CNS pharma, biotech, or relevant academic institutions.

Skills

None specified in the job posting.

Benefits

By joining DSV, you'll be joining a team of operators who have founded companies and led translation of science at some of the most respected universities, charities, funds and government agencies. 2/3 of the team have founded or led a company at C-suite and 65% have a PhD. Our team dedicate several hours every week to each Founder or founding team to provide tailored guidance, resources and feedback covering every aspect of what it takes to successfully launch a new venture from both the tech and commercial perspectives:

  • We provide optimised, purpose-built, proprietary tools, resources and processes to help create high-impact ventures from scratch, using our venture creation methodology;
  • DSV and the Partners' extensive network, technical, commercial and fundraising domain expertise, and wide-ranging portfolio company capabilities;
  • We jointly provide an initial £250k (:$330k / €290k) investment governed by our Investment Committee to incorporate the new venture and develop early proof-of-concept data that is often needed to attract high profile non-venture studio VCs. This funding is also key for obtaining grant funding, which often needs to be matched with private investment;
  • You and your co-founder(s) together will own the majority equity stake in the company;
  • We provide minimum guaranteed income of £4,166 per month (fixed), paid to each Founder as a consultancy fee until the company is launched and pre-seed investment is secured;
  • We provide continuous support post spin-out, including fundraising, commercial partnerships, recruitment and team-building (amongst other things);
  • Other Founders currently at DSV across sectors working collaboratively and supporting one another - a unique resource to draw on.

Pay

£4,166 per month (fixed) until the company is launched and pre-seed investment is secured.

Schedule

Full-time, remote initially until venture incorporation and spin-out (circa end of 2027), location TBD.

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