FDA Research Opportunity for Bioinformatic Studies Involving the Evaluation of Human Sex-Biased microRNAs in Coagulation Proteins
Research Project
Under the guidance of the mentor, the participant will investigate sex-biased microRNAs (miRNAs) and their regulatory effects on coagulation proteins, with an initial focus on ADAMTS13 and potential extension to other targets such as von Willebrand Factor (VWF) and Factor IX (FIX).
The project will evaluate whether sex-biased miRNAs can bind to the coding sequence (CDS) and untranslated regions (UTRs) of coagulation factor transcripts and regulate protein expression. In addition, the participant will assess whether known genetic variants disrupt miRNA interactions by causing loss or gain of miRNA binding sites, potentially altering protein function and contributing to sex-dependent differences in bleeding disorders such as thrombotic thrombocytopenic purpura (TTP) and von Willebrand Disease (VWD).
Mentor
The mentor for this opportunity is Chava Kimchi-Sarfaty (chava.kimchi-sarfaty@fda.hhs.gov).
Learning Objectives
- Develop understanding of sex-biased miRNA regulation in hemostasis and coagulation protein expression
- Learn to apply bioinformatics and in-silico prediction tools to identify miRNA-target gene interactions within CDS and UTR regions
- Gain experience using publicly available genomic, transcriptomic, SNP, and miRNA databases for regulatory sequence analysis
- Learn approaches for predicting how genetic variants may disrupt or create miRNA binding sites and alter regulatory interactions
- Develop skills in sequence analysis, variant annotation, and interpretation of miRNA–mRNA interaction datasets, including AGO-CLIP resources where applicable
- Understand computational strategies for evaluating coagulation-related genes and variants associated with bleeding disorders
- Apply acquired knowledge to support FDA regulatory science and women’s health research initiatives through computational evaluation of sex-specific regulatory mechanisms in coagulation biology
Qualifications
- The qualified candidate should be currently pursuing or have received a master's or doctoral degree in the relevant fields (e.g. molecular and cell biology, pharmacology and drug discovery/development).
- Preference will be given to candidates who have lab skills in common molecular and cell biology techniques.
- Preferred skills: Lab skills in common molecular and cell biology techniques.
Contact Information
If you have questions, send an email to ORISE.FDA.OC.other@orau.org. Please include the reference code for this opportunity in your email.
To submit your application, scroll to the bottom of this opportunity and click APPLY.
All documents must be in English or include an official English translation.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive proof of health insurance is required for participation in this program.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend commensurate with educational level and experience.
The participant will receive a monthly stipend