Faculty Position: Cancer Cell Surfaceome/Novel Therapeutic Design Scientist
for section headings like About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. We must include only sections with real specific content. We need to extract content.
The posting includes:
- Position Description (maybe About the role)
- Responsibilities (multiple paragraphs)
- Strategic Role and Leadership Expectations (maybe part of responsibilities)
- Key Areas of Scientific Focus (maybe part of responsibilities)
- Research Environment (maybe About the role)
- Why Mayo Clinic Comprehensive Cancer Center (MCCCC)? (maybe About the role)
- Why Choose Mayo Clinic Arizona? (maybe Benefits? Actually it's about benefits and environment)
- Qualifications (list)
- Exemption Status Exempt
- Benefits Eligible Yes
- Schedule Full Time Hours/Pay Period 80
- Schedule Details daily
- International Assignment No
- Recruiter Natalie Brewster (metadata, maybe drop)
We must not repeat job title as heading. No Job ID.
We need to output only HTML fragment, no /, no markdown fences.
We need to use for section headings. Use - for any list of duties/requirements/benefits. Use
for prose.
We need to preserve all substantive information, not invent or summarize away detail. Remove boilerplate (cookie/navigation/legal/EEO etc). There's none.
We need to include a section only when posting has real specific content for it. So we need sections: About the role (maybe combine Position Description and Research Environment and Why Mayo Clinic etc). Responsibilities (the detailed responsibilities). Qualifications (list). Benefits? There's mention of Benefits Eligible Yes, but no detail of benefits. The instruction: never create Benefits section unless posting actually states them. It says "Benefits Eligible Yes" but not details. That's minimal; maybe we can include a short
under Benefits? But they said never create Benefits section unless posting actually states them. It does state "Benefits Eligible Yes". That's a statement about benefits eligibility, but not details. Could be considered stating them. However they also said prefer a few substantive sections over many thin ones. Might be better to fold that into a short
under About the role or Qualifications? Probably better to include a Benefits section with that line? But they said "never create Pay/Schedule/Benefits sections unless the posting actually states them." It does state Benefits Eligible Yes, so we can include Benefits section with that line. However they also said "Prefer a few substantive sections over many thin ones." So maybe we can combine Benefits with something else? But we need to follow instruction: include a section only when posting has real specific content for it. Benefits Eligible Yes is specific content (though minimal). So we can include Benefits section with that line.
Similarly Schedule: they give Full Time Hours/Pay Period 80, Schedule Details daily. That's specific. So we can include Schedule section.
Pay: not mentioned (no salary). So we should not create Pay section.
Skills: not explicitly listed separate; qualifications cover skills. Could we create Skills section? Probably not needed; we can put skills under Qualifications.
Thus sections: About the role (maybe combine Position Description, Research Environment, Why Mayo Clinic, Why Choose Mayo Clinic Arizona). Responsibilities (the detailed responsibilities). Qualifications (list). Benefits (Benefits Eligible Yes). Schedule (Full Time Hours/Pay Period 80, Schedule Details daily, International Assignment No). Possibly also Exemption Status Exempt? Could be part of About the role or maybe a separate section? Not in list of allowed headings; we could fold into About the role as a short p.
We must not include headings like "Exemption Status". So we incorporate that info into About the role as a sentence.
We need to preserve all substantive information. Let's extract.
Position Description paragraph:
"The Mayo Clinic Comprehensive Cancer Center in Arizona invites applications for an open-rank faculty position with a commitment to advancing cancer research into clinical impact. Mayo Clinic Comprehensive Cancer Center in Arizona is building a world-class research hub to transform cancer patient care through actionable target discovery and next-generation therapeutic platforms. This initiative sits at the intersection of basic discovery science defining cell surfaceome mapping and immune-antigen discovery, through the development of cellular therapeutics, vaccine manufacturing, immuno-therapeutics, and theranostics, supported by strong clinical and clinical trial programs and strategic collaborations. Qualified investigators will have a focus along the continuum from discovery science on the identification and characterization of cancer-related epitopes and the associated immunologic response as the foundation of novel therapeutics for clinical deployment in the setting of cancer prevention in high-risk individuals, early cancer detection, mitigation of nascent cancer progression (“cancer interception”), and therapeutic applications for established disease. Potential therapeutic designs include but are not limited to cellular therapeutics, vaccine modalities and radiotheranostics."
Then "Strategic Role and Leadership Expectations The Research Scientist Will Participate in institutional initiatives aligned with Mayo Clinic and Mayo Clinic Comprehensive Cancer Center’s vision to Cure, Connect, and Transform cancer care through transformative science.Lead an independent, externally funded research program in developmental therapeutics for translational science focused within the continuum of cancer cell surfaceome mapping through novel cancer therapeutics. This may include:Identification and validation of novel tumor antigens (“neoantigens”) for applications in therapeutics and diagnostics (theranostics).Characterization of immunologic response to cancer-related immunopeptidomicsContribute to the development of next-generation therapeutic platforms such as immunotherapies, cellular therapies, and nucleic acid-based vaccinesConduct/coordinate pre-IND enabling research for acceleration of novel therapeutics into First-In-Human early phase clinical trialsContribute to the development of next-generation therapeutic platforms focused on immunotherapies, cellular therapies, antibodies/nanobodies, radiopharmaceuticals and nucleic acid-based vaccines. Collaborate across multidisciplinary teams to translate discoveries into clinical-grade therapeutics with coordination of internal/external manufacturing processes. Actively engage in Mayo Clinic Comprehensive Cancer Center activitiesEngage in enterprise-wide collaborations across Mayo Clinic sites (Rochester, MN; Phoenix and Scottsdale, AZ; Jacksonville, FL) with external partners, including Arizona State University, and numerous biotechnology partners.Mentor trainees and contribute to a collaborative, inclusive research environment."
Then "Key Areas of Scientific Focus RNA Biology & Transcriptomic Insights: Leverage bulk and single-cell RNA sequencing to characterize tumor-specific expression, alternative splicing events, RNA editing, and non-canonical transcripts (e.g., fusion genes, retained introns, dark proteins). Immunopeptidomics & Antigen Presentation: Utilize mass spectrometry–based immunopeptidomics to directly profile peptides presented on HLA molecules. Map the repertoire of naturally presented tumor-associated and tumor-specific antigens to validate biological relevance beyond transcript-level predictions.AI-Driven Target Prediction & Prioritization: Develop and apply machine learning and deep learning models to predict antigen processing, HLA binding affinity, peptide stability, and immunogenicity. Immune Receptor Discovery & Modeling: TCR/BCR repertoire analysis and/or deep learning approaches for antigen prediction and functional immune response assessment. Binder & Platform Development: Generation of antibodies, nanobodies, peptides, or RNA-based payloads adaptable across therapeutic modalities. Translate target discovery to immunotherapy, cellular therapy, oligonucleotide-based vaccines, or radio-theranostics.Therapeutic Applications: Experience with on-target/off-target validation of therapeutic potential in pre-clinical model systemsFirst-In-Human Therapeutic Development: Coordinate/conduct pre-IND enabling studies for acceleration of novel therapeutics from design through manufacturing to Phase I trials.Clinical & Translational Relevance: Incorporate patient-derived datasets and clinical annotations to prioritize targets with high relevance across patient populations and disease subtypes.End-to-End Target Nomination Pipeline: Build scalable pipelines that connect discovery to validation. Ensure targets are suitable for downstream modalities such as T cell engagers, CAR-T therapies, antibody-drug conjugates (ADCs), or cancer vaccines.Clinical & Translational Relevance: Incorporate patient-derived datasets and clinical annotations to prioritize targets with high relevance across patient populations and disease subtypes."
Then "Research Environment Mayo Clinic And Mayo Clinic Comprehensive Cancer Center In Arizona Offers a Highly Collaborative And Integrated Academic Medical Center Environment With Expanding Strengths In Cell Therapy, Cancer Immunotherapy, Regenerative Medicine, And Translational Science. Faculty Benefit From Established CAR-T and immune cell therapy programs with active clinical translationState-of-the-art genome engineering and cell manufacturing infrastructureAccess to institutional core facilities including genomics, single-cell sequencing, proteomics, bioinformatics, and advanced imagingFocused drive to launch first-in-human trails to bring new treatments to patients Dedicated institutional support for regulatory strategy, clinical trial development, and commercialization pathwaysDeveloping biotechnology corridor attracting partner companies for the accelerating translation of discoveries. Cross-campus collaboration opportunities with Mayo Clinic sites in Minnesota and Florida The selected candidate will help shape a coordinated, forward-looking drug discovery and development program that advances novel agents from bench to bedside."
Then "Why Mayo Clinic Comprehensive Cancer Center (MCCCC)? With 440 members and >1500 aligned cancer physicians working in six Cancer Research Programs (Cancer Prevention, Survivorship & Control; Cancer Risk Assessment, Early Detection & Interception; Cancer Genomics, Signaling, & Metastasis; Cancer Immunology & Immunotherapeutics; Novel Therapeutics & Therapeutic Modalities; Advanced Clinical Trials and Translational Sciences) and 15 Disease Groups focused on clinical trials, MCCCC is a global leader and represents the pinnacle of cancer care, research and education and training. Every year, across its three enterprise sites (Rochester, Minnesota; Phoenix and Scottsdale, Arizona; and Jacksonville, Florida), MCCCC physicians provide expert cancer diagnosis and treatment to more than 150,000 unique patients from across the nation and the globe. The MCCCC Misson: To inspire hope and promote health and healing through integrated research, clinical practice, and education, centered around our primary value: the needs of the patient come first. The MCCCC Vision: To be a global cancer authority: transforming cancer research and practice to assure that our discoveries, knowledge, and expertise are accessible to all, within and beyond our walls, at anyplace and anytime. MCCCC Goals To cure cancers through translation of innovative transdisciplinary science to new means of prevention, early detection, interception, intervention, and unparalleled care delivery. To transform cancer research and practice using category of one data platforms, digital technologies, artificial intelligence (AI), and intelligent automation, creating new models for community and patient engagement, and the conduct of research, clinical trials and patient-centered care delivery in clinical, home, and community settings. To use Mayo Clinic Platform to engage patients and communities in our catchment areas and across the nation and the world in cancer research and distributed and decentralized clinical trials.To educate, train, and mentor the next generation of cancer physicians, scientists, and leaders. Over the past year, MCCCC has continued to achieve exceptional performance metrics, with high levels of cancer research funding (reporting $61.2M in annual peer-reviewed funding ($41.1M from NCI) and $98.7M in industry and non-peer reviewed funding). The Center currently has over 80 multi-investigator programmatic grants including 6 NCI Specialized Programs of Research Emphasis (SPORES): Myeloma, Ovarian Cancer, Breast Cancer, Liver/Hepatobiliary Cancers, Prostate Cancer, and Sarcoma. In 2025, clinical trial accrual has remained robust, reporting the Center’s highest accrual to therapeutic interventional trials: 2,624 (12% of newly registered cases), with 6,588 interventional accruals (30% of newly registered patients) and 10,367 non-interventional accruals. In 2025, MCCCC members published an exceptional number (1776) of peer-reviewed academic works, 24% of which were published in high impact journals."
Then "Why Choose Mayo Clinic Arizona? Mayo Clinic Is a Premier, Integrated Academic Medical Center Consistently Ranked Among The Top Hospitals In The Nation. The Arizona Campus Is Experiencing Strategic Growth In Cancer Immun
- for any list of duties/requirements/benefits. Use
for prose. We need to preserve all substantive information, not invent or summarize away detail. Remove boilerplate (cookie/navigation/legal/EEO etc). There's none. We need to include a section only when posting has real specific content for it. So we need sections: About the role (maybe combine Position Description and Research Environment and Why Mayo Clinic etc). Responsibilities (the detailed responsibilities). Qualifications (list). Benefits? There's mention of Benefits Eligible Yes, but no detail of benefits. The instruction: never create Benefits section unless posting actually states them. It says "Benefits Eligible Yes" but not details. That's minimal; maybe we can include a short
under Benefits? But they said never create Benefits section unless posting actually states them. It does state "Benefits Eligible Yes". That's a statement about benefits eligibility, but not details. Could be considered stating them. However they also said prefer a few substantive sections over many thin ones. Might be better to fold that into a short
under About the role or Qualifications? Probably better to include a Benefits section with that line? But they said "never create Pay/Schedule/Benefits sections unless the posting actually states them." It does state Benefits Eligible Yes, so we can include Benefits section with that line. However they also said "Prefer a few substantive sections over many thin ones." So maybe we can combine Benefits with something else? But we need to follow instruction: include a section only when posting has real specific content for it. Benefits Eligible Yes is specific content (though minimal). So we can include Benefits section with that line. Similarly Schedule: they give Full Time Hours/Pay Period 80, Schedule Details daily. That's specific. So we can include Schedule section. Pay: not mentioned (no salary). So we should not create Pay section. Skills: not explicitly listed separate; qualifications cover skills. Could we create Skills section? Probably not needed; we can put skills under Qualifications. Thus sections: About the role (maybe combine Position Description, Research Environment, Why Mayo Clinic, Why Choose Mayo Clinic Arizona). Responsibilities (the detailed responsibilities). Qualifications (list). Benefits (Benefits Eligible Yes). Schedule (Full Time Hours/Pay Period 80, Schedule Details daily, International Assignment No). Possibly also Exemption Status Exempt? Could be part of About the role or maybe a separate section? Not in list of allowed headings; we could fold into About the role as a short p. We must not include headings like "Exemption Status". So we incorporate that info into About the role as a sentence. We need to preserve all substantive information. Let's extract. Position Description paragraph: "The Mayo Clinic Comprehensive Cancer Center in Arizona invites applications for an open-rank faculty position with a commitment to advancing cancer research into clinical impact. Mayo Clinic Comprehensive Cancer Center in Arizona is building a world-class research hub to transform cancer patient care through actionable target discovery and next-generation therapeutic platforms. This initiative sits at the intersection of basic discovery science defining cell surfaceome mapping and immune-antigen discovery, through the development of cellular therapeutics, vaccine manufacturing, immuno-therapeutics, and theranostics, supported by strong clinical and clinical trial programs and strategic collaborations. Qualified investigators will have a focus along the continuum from discovery science on the identification and characterization of cancer-related epitopes and the associated immunologic response as the foundation of novel therapeutics for clinical deployment in the setting of cancer prevention in high-risk individuals, early cancer detection, mitigation of nascent cancer progression (“cancer interception”), and therapeutic applications for established disease. Potential therapeutic designs include but are not limited to cellular therapeutics, vaccine modalities and radiotheranostics." Then "Strategic Role and Leadership Expectations The Research Scientist Will Participate in institutional initiatives aligned with Mayo Clinic and Mayo Clinic Comprehensive Cancer Center’s vision to Cure, Connect, and Transform cancer care through transformative science.Lead an independent, externally funded research program in developmental therapeutics for translational science focused within the continuum of cancer cell surfaceome mapping through novel cancer therapeutics. This may include:Identification and validation of novel tumor antigens (“neoantigens”) for applications in therapeutics and diagnostics (theranostics).Characterization of immunologic response to cancer-related immunopeptidomicsContribute to the development of next-generation therapeutic platforms such as immunotherapies, cellular therapies, and nucleic acid-based vaccinesConduct/coordinate pre-IND enabling research for acceleration of novel therapeutics into First-In-Human early phase clinical trialsContribute to the development of next-generation therapeutic platforms focused on immunotherapies, cellular therapies, antibodies/nanobodies, radiopharmaceuticals and nucleic acid-based vaccines. Collaborate across multidisciplinary teams to translate discoveries into clinical-grade therapeutics with coordination of internal/external manufacturing processes. Actively engage in Mayo Clinic Comprehensive Cancer Center activitiesEngage in enterprise-wide collaborations across Mayo Clinic sites (Rochester, MN; Phoenix and Scottsdale, AZ; Jacksonville, FL) with external partners, including Arizona State University, and numerous biotechnology partners.Mentor trainees and contribute to a collaborative, inclusive research environment." Then "Key Areas of Scientific Focus RNA Biology & Transcriptomic Insights: Leverage bulk and single-cell RNA sequencing to characterize tumor-specific expression, alternative splicing events, RNA editing, and non-canonical transcripts (e.g., fusion genes, retained introns, dark proteins). Immunopeptidomics & Antigen Presentation: Utilize mass spectrometry–based immunopeptidomics to directly profile peptides presented on HLA molecules. Map the repertoire of naturally presented tumor-associated and tumor-specific antigens to validate biological relevance beyond transcript-level predictions.AI-Driven Target Prediction & Prioritization: Develop and apply machine learning and deep learning models to predict antigen processing, HLA binding affinity, peptide stability, and immunogenicity. Immune Receptor Discovery & Modeling: TCR/BCR repertoire analysis and/or deep learning approaches for antigen prediction and functional immune response assessment. Binder & Platform Development: Generation of antibodies, nanobodies, peptides, or RNA-based payloads adaptable across therapeutic modalities. Translate target discovery to immunotherapy, cellular therapy, oligonucleotide-based vaccines, or radio-theranostics.Therapeutic Applications: Experience with on-target/off-target validation of therapeutic potential in pre-clinical model systemsFirst-In-Human Therapeutic Development: Coordinate/conduct pre-IND enabling studies for acceleration of novel therapeutics from design through manufacturing to Phase I trials.Clinical & Translational Relevance: Incorporate patient-derived datasets and clinical annotations to prioritize targets with high relevance across patient populations and disease subtypes.End-to-End Target Nomination Pipeline: Build scalable pipelines that connect discovery to validation. Ensure targets are suitable for downstream modalities such as T cell engagers, CAR-T therapies, antibody-drug conjugates (ADCs), or cancer vaccines.Clinical & Translational Relevance: Incorporate patient-derived datasets and clinical annotations to prioritize targets with high relevance across patient populations and disease subtypes." Then "Research Environment Mayo Clinic And Mayo Clinic Comprehensive Cancer Center In Arizona Offers a Highly Collaborative And Integrated Academic Medical Center Environment With Expanding Strengths In Cell Therapy, Cancer Immunotherapy, Regenerative Medicine, And Translational Science. Faculty Benefit From Established CAR-T and immune cell therapy programs with active clinical translationState-of-the-art genome engineering and cell manufacturing infrastructureAccess to institutional core facilities including genomics, single-cell sequencing, proteomics, bioinformatics, and advanced imagingFocused drive to launch first-in-human trails to bring new treatments to patients Dedicated institutional support for regulatory strategy, clinical trial development, and commercialization pathwaysDeveloping biotechnology corridor attracting partner companies for the accelerating translation of discoveries. Cross-campus collaboration opportunities with Mayo Clinic sites in Minnesota and Florida The selected candidate will help shape a coordinated, forward-looking drug discovery and development program that advances novel agents from bench to bedside." Then "Why Mayo Clinic Comprehensive Cancer Center (MCCCC)? With 440 members and >1500 aligned cancer physicians working in six Cancer Research Programs (Cancer Prevention, Survivorship & Control; Cancer Risk Assessment, Early Detection & Interception; Cancer Genomics, Signaling, & Metastasis; Cancer Immunology & Immunotherapeutics; Novel Therapeutics & Therapeutic Modalities; Advanced Clinical Trials and Translational Sciences) and 15 Disease Groups focused on clinical trials, MCCCC is a global leader and represents the pinnacle of cancer care, research and education and training. Every year, across its three enterprise sites (Rochester, Minnesota; Phoenix and Scottsdale, Arizona; and Jacksonville, Florida), MCCCC physicians provide expert cancer diagnosis and treatment to more than 150,000 unique patients from across the nation and the globe. The MCCCC Misson: To inspire hope and promote health and healing through integrated research, clinical practice, and education, centered around our primary value: the needs of the patient come first. The MCCCC Vision: To be a global cancer authority: transforming cancer research and practice to assure that our discoveries, knowledge, and expertise are accessible to all, within and beyond our walls, at anyplace and anytime. MCCCC Goals To cure cancers through translation of innovative transdisciplinary science to new means of prevention, early detection, interception, intervention, and unparalleled care delivery. To transform cancer research and practice using category of one data platforms, digital technologies, artificial intelligence (AI), and intelligent automation, creating new models for community and patient engagement, and the conduct of research, clinical trials and patient-centered care delivery in clinical, home, and community settings. To use Mayo Clinic Platform to engage patients and communities in our catchment areas and across the nation and the world in cancer research and distributed and decentralized clinical trials.To educate, train, and mentor the next generation of cancer physicians, scientists, and leaders. Over the past year, MCCCC has continued to achieve exceptional performance metrics, with high levels of cancer research funding (reporting $61.2M in annual peer-reviewed funding ($41.1M from NCI) and $98.7M in industry and non-peer reviewed funding). The Center currently has over 80 multi-investigator programmatic grants including 6 NCI Specialized Programs of Research Emphasis (SPORES): Myeloma, Ovarian Cancer, Breast Cancer, Liver/Hepatobiliary Cancers, Prostate Cancer, and Sarcoma. In 2025, clinical trial accrual has remained robust, reporting the Center’s highest accrual to therapeutic interventional trials: 2,624 (12% of newly registered cases), with 6,588 interventional accruals (30% of newly registered patients) and 10,367 non-interventional accruals. In 2025, MCCCC members published an exceptional number (1776) of peer-reviewed academic works, 24% of which were published in high impact journals." Then "Why Choose Mayo Clinic Arizona? Mayo Clinic Is a Premier, Integrated Academic Medical Center Consistently Ranked Among The Top Hospitals In The Nation. The Arizona Campus Is Experiencing Strategic Growth In Cancer Immun