Engineer III, ADME

Key Responsibilities

• Execute, optimize, and help validate a range of in vitro ADME assays such as solubility, MDCK permeability, plasma protein binding, microsomal stability, hepatocyte stability, and CYP inhibition/induction.
• Perform sample preparation and analytical workflows for high-throughput ADME studies, including LC-MS/MS, high-throughput mass spectrometry, and related mass spectrometry-based readouts.
• Contribute to HT-mass spec and metabolomics-informed workflows for compound profiling, assay readout generation, and interpretation of pathway- or metabolism-relevant signals where appropriate.
• Support transfer of manual methods into higher-throughput and automation-enabled workflows, working with liquid handlers and related instrumentation where appropriate.
• Troubleshoot assay, instrument, and workflow issues; identify root causes and improve robustness, throughput, and data quality over time.

Data Analysis & Reporting

• Analyze, interpret, and summarize ADME data, including key assay outputs and pharmacokinetic-relevant parameters.
• Present results clearly to medicinal chemistry and cross-functional project teams to support compound progression and decision-making.
• Partner with computational and data teams to ensure data outputs are structured, QC’d, and analysis-ready.

Operational Excellence

• Maintain clear, accurate laboratory records, SOPs, and electronic notebooks.
• Ensure laboratory activities comply with internal quality expectations and safety requirements.
• Contribute to SOPs, runbooks, checklists, and workflow documentation so established assays can be executed reproducibly and transferred across the team.

Cross-Functional Collaboration

• Work closely with ADME, automation, analytical, and data colleagues to scope work, communicate progress, and deliver high-quality data on timeline.
• Contribute to team knowledge sharing, onboarding, and day-to-day collaboration in a fast-moving platform environment.