Engineer II, Conjugation Development and Manufacturing

About the role

Vaxcyte is seeking a highly motivated and technically proficient Engineer II to join the Conjugation Process Development and Manufacturing group within the CMC organization. This role supports the development, scale up, and manufacturing of Vaxcyte’s multi-valent polysaccharide-based conjugate vaccines, leveraging a novel carrier protein produced through cell-free synthesis. The successful candidate will contribute to the advancement of Vaxcyte’s vaccine programs while developing deep expertise in conjugation process development and manufacturing.

Essential Functions

• Operation and maintenance of laboratory equipment, including chemical reactors, TFF systems, HPLCs, and plate readers.
• Support the design and execution of development studies to optimize and characterize conjugation processes.
• Provide technical oversight during cGMP production campaigns, including preparation, on-floor support, troubleshooting, deviation assessment, and change control execution.
• Review executed protocols and batch records for accuracy, completeness, and compliance.
• Serve as a subject matter expert for conjugation related activities on project teams.
• Contribute to facility and equipment design considerations to support process scale-up and manufacturing readiness.
• Participate in the development of conjugation processes for pipeline programs.
• Maintain accurate and complete documentation in laboratory notebooks or electronic systems.
• Engage in technical discussions and contribute to data interpretation and decision-making.
• Collaborate effectively within a team environment to support departmental and program objectives.

Requirements

• PhD with 2-5 years of experience, MS with minimum of 7 years, BS/BA with minimum of 10 years of experience in Chemical Engineering, Biochemical Engineering, Chemistry, Biology, or a related discipline.
• Practical experience with bioprocess operations at bench, pilot, or manufacturing scale.
• Strong working knowledge of cGMP principles and their application in bioprocess environments.
• Foundational understanding of engineering principles relevant to bioprocess development and scale-up.
• Proficiency with standard software tools, including Excel, Word, PowerPoint, Visio, and JMP.
• Demonstrated ability to work in cross-functional teams and manage multiple concurrent activities.
• Excellent written and verbal communication skills.

Pay

N/A

Schedule

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Benefits

N/A