Engineer 3

About the role

We are seeking a dynamic and agile Engineer III to join the Focused Modalities Applications group within Process Solutions Product Development at MilliporeSigma in Bedford, MA. In this role, you will work within a matrixed team to deliver bioprocessing applications data that helps solve customer challenges and showcases the value of our commercial products for novel modality process optimization & manufacturing.

Drawing on expertise in upstream bioreactor operations and bioprocess development, the successful candidate will plan, execute, and interpret laboratory, bench-, and pilot-scale bioreactor studies to evaluate new technologies and optimize processes for emerging modalities such as novel mAbs (bispecifics, multi-specifics) and cell and gene therapies. This position supports team growth by mentoring peers, synthesizing end-user requirements, and expanding capabilities to keep pace with state-of-the-art developments and thought leadership in novel bioprocessing. The successful candidate will have a passion for process development, strong cross-functional problem-solving skills, and the ability to collaborate with experts in downstream processing and PAT development teams.

Responsibilities

• Plan, execute, and interpret laboratory, bench-, and pilot-scale bioreactor studies to evaluate new technologies and optimize processes for emerging modalities.
• Support novel modality process optimization and manufacturing for modalities such as novel mAbs (bispecifics, multi-specifics) and cell and gene therapies.
• Mentor peers and synthesize end-user requirements to expand team capabilities.
• Collaborate with downstream processing and PAT development teams.

Requirements

• Bachelor’s Degree in Chemistry, Biochemistry, Process Engineering, Mechanical Engineering, or other Life Science or Engineering Discipline and 7+ years of industry experience.
• OR Master’s Degree in Chemistry, Biochemistry, Process Engineering, Mechanical Engineering, or other Life Science or Engineering Discipline and 4+ years of industry experience.
• OR PhD in Chemistry, Biochemistry, Process Engineering, Mechanical Engineering, or other Life Science or Engineering Discipline and 2+ years of industry experience.

Qualifications

• Experience with planning and executing upstream unit operations including setup and operation of single-use bioreactors across multiple scales.
• Strong expertise and hands-on experience in upstream bioprocessing for CHO-based systems including novel mAb applications (bispecifics/multi-specifics); knowledge in cell and gene therapy applications is a bonus.
• Proficient in optimizing and transferring mammalian bioprocesses from laboratory to large-scale production platforms using scale-up/scale-down approaches and technology transfer.
• Exposure to some of the following analytical techniques: cell counting, metabolite analysis, protein quantification, glycan and charge variant analysis; flow cytometry, PCR, and ELISA experience.
• Skilled in statistical analysis, experimental design, and design of experiments (DoE) approaches.
• Experience leading small to medium-size projects; demonstrated ability to deliver on timelines while balancing scientific rigor and customer urgency.
• Effectively communicates through written reports, oral presentations, application notes, poster presentations, and similar media.
• Familiarity with lab automation and GMP practices.

Pay

The pay range for this position is $85,500 – $149,800 per year. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses.

Benefits

• Health insurance
• Paid time off (PTO)
• Retirement contributions
• Other perquisites