DMPK Research Associate/Scientist

Responsibilities

• Bioanalysis: plasma and tissue processing/analysis to determine the drug concentration using the Sciex LC/MS-MS.
• Plasma Protein Binding Studies: Conduct experiments to determine the binding affinity of compounds to plasma proteins using Sciex LC/MS-MS.
• Microsomal Assays: Perform microsomal stability studies to assess the metabolic stability and run the assay using the Sciex LC/MS-MS.
• Data Analysis and Interpretation: Analyze experimental data using appropriate software (WNL) and statistical methods and provide clear and concise summaries of findings to support decision-making.
• Documentation and Reporting: Maintain detailed records of experimental procedures, results, and observations in laboratory notebooks and electronic databases. Prepare technical reports and presentations for internal meetings and regulatory submissions.
• Collaboration: Collaborate effectively with cross-functional teams, including medicinal chemistry, pharmacology, and toxicology, to support drug discovery and development projects.
• Lab Maintenance: Ensure proper maintenance and organization of laboratory equipment, reagents, and supplies. Adhere to safety protocols and maintain a clean and safe working environment.

Qualifications

• Bachelor's with 3 to 5 years of experience or Master's degree in Pharmaceutical Sciences, Chemistry, Biochemistry, or a related field with 2 to 4 years.
• Hands-on experience with DMPK assays, including screening, plasma protein binding, and microsomal assays are preferred but not required.
• Proven analytical and problem-solving skills, with the ability to critically evaluate and interpret experimental data.