DMPK Scientist

Small Molecule DMPK / Bioanalysis Scientist Open to Sr. RA $35-45/hr OR scientist $50-62/hr Job Description This role focuses on hands-on small molecule bioanalysis within a nimble drug metabolism and pharmacokinetics (DMPK) environment. The contractor supports end-to-end bioanalytical workflows, including tissue and plasma sample preparation, LC‑MS/MS methods, and pharmacokinetic and pharmacometric analyses. The position suits someone who enjoys working at the bench, can quickly integrate into a collaborative team, and operates independently with minimal guidance while contributing across the full DMPK workflow. Responsibilities Perform hands-on tissue and plasma sample preparation to support small molecule bioanalysis, ensuring accurate handling, labeling, and tracking of all samples.Prepare and execute calibration curves and dilutions to support robust LC‑MS/MS quantitation of small molecules.Conduct sample thawing and processing activities in accordance with established bioanalytical protocols and quality standards.Support and execute LC‑MS/MS workflows for small molecule bioanalysis, including instrument setup, basic troubleshooting, and routine operation.Contribute to pharmacokinetic and pharmacometric (PK/PD) analyses using tools such as NONMEM and PsN, supporting data analysis and interpretation.Perform plasma protein binding assays and related in vitro studies as needed to support small molecule characterization.Support microsomal and other in vitro ADME assays as required, contributing to broader DMPK and bioanalysis studies.Work across the full DMPK workflow with limited handholding, taking ownership of assigned experiments and tasks from planning through execution and documentation.Collaborate closely with a small, nimble DMPK team to prioritize tasks, troubleshoot issues, and ensure timely delivery of high-quality data.Document experimental procedures, results, and observations clearly and accurately in laboratory records and reports.Follow laboratory best practices, standard operating procedures, and safety guidelines while maintaining a clean and organized work area.Contribute proactively to process improvements and workflow optimization within the DMPK and bioanalysis function. Essential Skills Hands-on experience in small molecule bioanalysis within a DMPK or related laboratory environment.Strong background in bioanalysis, including tissue and plasma sample preparation and handling.Proficiency with LC‑MS/MS workflows for quantitative analysis of small molecules.Demonstrated ability to prepare calibration curves and perform accurate dilutions for bioanalytical assays.Experience with sample thawing, processing, and management in a regulated or process-driven laboratory setting.Practical experience with pharmacokinetic and pharmacometric analysis tools such as NONMEM and PsN.Ability to support the full DMPK workflow from sample preparation through data generation with limited supervision.Capability to operate independently, take initiative, and manage multiple tasks in a fast-paced environment.Strong documentation skills and attention to detail in recording experimental procedures and results.Excellent collaboration and communication skills to work effectively within a small, cross-functional team. Additional Skills & Qualifications Experience with plasma protein binding assays to characterize small molecule binding properties.Experience with microsomal assays and other in vitro ADME studies.Broader ADME and DMPK experience beyond core bioanalysis responsibilities.PhD in a relevant scientific discipline (such as pharmacology, pharmaceutical sciences, chemistry, or a related field).Postdoctoral experience in DMPK, bioanalysis, or a closely related area.Familiarity with additional DMPK tools, software, and workflows is advantageous.Interest in gaining comprehensive exposure to end-to-end DMPK workflows within a dynamic team environment. Work Environment The role is based within a nimble DMPK team in a laboratory setting in South San Francisco. The environment is highly hands-on and collaborative, with a strong emphasis on flexibility and willingness to support multiple parts of the DMPK and bioanalysis workflow. You will work closely with a small group of scientists who value open communication, shared problem-solving, and direct contributions to project progress. The position offers the opportunity to gain extensive, practical experience across the full DMPK workflow, including sample preparation, LC‑MS/MS operations, and data analysis. This is a one-year contract with potential for extension, providing a focused period to deepen technical skills and contribute meaningfully to small molecule bioanalysis in a fast-moving research setting. Job Type & Location This is a Contract to Hire position based out of South San Francisco, CA. Pay And Benefits The pay range for this position is $35.00 - $45.00/hr. Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following: Medical, dental & vision Critical Illness, Accident, and Hospital 401(k) Retirement Plan – Pre-tax and Roth post-tax contributions available Life Insurance (Voluntary Life & AD&D for the employee and dependents) Short and long-term disability Health Spending Account (HSA) Transportation benefits Employee Assistance Program Time Off/Leave (PTO, Vacation or Sick Leave) Workplace Type This is a hybrid position in South San Francisco,CA. Application Deadline This position is anticipated to close on Aug 8, 2026. About Actalent Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 20,000 consultants and 5,000 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500. We are proud to be an Engineering News-Record (ENR) Top 500 Design Firm for our engineering design services and a ClearlyRated Best of Staffing® winner for both client and talent service. The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law. If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email actalentaccommodation@actalentservices.com for other accommodation options. San Francisco Fair Chance Ordinance: Pursuant to the San Francisco Fair Chance Ordinance, for all positions located in the city and county of San Francisco, we will consider for employment qualified applicants with arrest and conviction records. Massachusetts Lie Detector: It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability. Use of Artificial Intelligence (AI): We may use Artificial Intelligence (AI) to support parts of our hiring process, including sourcing, screening, and evaluating candidates. AI helps assess applications and qualifications, but final decisions are made by our hiring team. By applying, you acknowledge and agree that your application may be reviewed using AI tools.