Discovery Postdoctoral Fellow in Neuroscience

About the role

The Discovery Postdoctoral Research Fellow will join the Neuroscience Disease Area in Cambridge to investigate mechanisms of TDP 43–driven neurodegeneration. They will work in a collaborative, multidisciplinary environment and contribute to the discovery of novel therapeutic targets.

Research Opportunity

This project aims to map early neuronal TDP-43 interaction networks influenced by disease-associated glial environments in ALS and Alzheimer's disease to identify shared, druggable targets across neurodegeneration.

Key Responsibilities

• Design and execute an independent, hypothesis-driven research program
• Develop and apply human iPSC-derived neuron and glial models
• Utilize genomics, proteomics, and transcriptomics approaches
• Analyze and integrate multi-omics datasets
• Collaborate with interdisciplinary teams across research units
• Communicate findings through presentations and peer-reviewed publications

Essential Requirements

• PhD (or equivalent) in neuroscience, biology, or related discipline (completed prior to fellowship start date)
• Demonstrated record of scientific achievement (publications, presentations, patents, or equivalent)
• Strong expertise in neurobiology, molecular and cell biology, or biochemistry
• Strong commitment to learning, innovation, and professional development
• Experience with human iPSC-derived neuronal or glial models
• Experience in confocal microscopy and high-content imaging and analysis
• Demonstrated ability to analyze complex proteomics datasets

Desirable Requirements

• Expertise in TDP-43 or apolipoprotein E biology and mechanisms of neurodegeneration
• Experience with protein interactome mapping (Halo µMapping) or chemo-proteomics

How to Apply

Please submit your CV and cover letter by July 25th, 2026. In your cover letter, describe your research interests, career aspirations, and how this fellowship will support your long-term development.

Compensation & Benefits

The starting salary for this position is 87,000 USD per year. US-based eligible employees will receive a comprehensive benefits package that includes health, life and disability benefits, a 401(k) with company contribution and match, and a variety of other benefits. In addition, employees are eligible for a generous time off package including vacation, personal days, holidays and other leaves.

EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.