Director, Pharmacometrics & Clinical Pharmacology

Responsibilities

• Provide leadership and subject matter expertise in pharmacometrics and clinical pharmacology across Arrowhead’s development portfolio.
• Contribute to global regulatory submissions, including marketing applications for siRNA-based therapeutics.
• Design and support clinical trial protocols, including dose selection and optimization strategies.
• Author and review clinical pharmacology sections of Investigational Brochures (IBs), Clinical Study Reports (CSRs), and other regulatory documents.
• Conduct and oversee analysis of clinical and translational PK/PD data, including population PK/PD modeling.
• Communicate analysis results, interpretation, and strategic recommendations to project teams in a timely and effective manner.
• Develop clinical pharmacology plans and propose dosing strategies across development stages.
• Maintain current knowledge of clinical pharmacology literature, regulatory guidance, and best practices relevant to oligonucleotide and RNAi therapeutics.

Requirements

• Doctoral degree (PhD, PharmD) in pharmacokinetics, pharmacology, pharmaceutical sciences, or a related discipline.
• 8 years of post-degree experience in the pharmaceutical or biotechnology industry in pharmacometrics or clinical pharmacology roles.
• Demonstrated expertise in population PK/PD modeling, with proficiency in standard software platforms such as NONMEM.
• Experience supporting regulatory submissions and interacting with cross-functional development teams.

Preferred

• Familiarity with PBPK/PD or quantitative systems pharmacology (QSP) modeling

Pay

Wisconsin pay range: $200,000 USD - $225,000 USD
California pay range: $220,000 USD - $245,000 USD