Director, LNP Formulation

Crosslinked Jobs/Biomaterials/Director, LNP Formulation KB Director, LNP Formulation Kernal Biologics Boston, MAtodayverified 2 h ago Lead LNP formulation development for mRNA delivery in cell therapy, managing team and advancing targeted delivery. Apply Apply Seniority Director+ Work On-site Type Full-time Degree PhD Experience 8–10 yrs Industry Biotechnology Role Management / Director Schedule Standard Materials lipid nanoparticles7biomaterials16novel lipids Techniques HPLC/UPLC5LC-MS7DLS16UV-Vis17Ribogreen assay2flow cytometry (CytoFLEX nano, NanoFCM) Benefits Free parking, monthly subway pass, or subsidized commuter rail passFree Bluebike MembershipOn-site cafeteria Role details About Kernal Biologics, Inc. Kernal Bio is a venture-backed therapeutics company engineering cells inside the body using AI-designed, selective mRNA and targeted LNP technology. By developing in vivo CAR-T therapies, Kernal Bio is advancing precision treatments for autoimmune diseases and blood cancers. The company was founded by experts from MIT, Harvard, Merck, and BMS, and its leadership team brings a track record of three FDA-approved therapies and over 120 patents. Based in Boston, the company is backed by Hummingbird Ventures, Amgen, Lilly, HBM, ARPA-H, and NVIDIA. Kernal Bio is transforming the future of cell therapy design and delivery. Job Summary Kernal is seeking an individual with deep expertise in RNA delivery space to lead our mRNA delivery efforts. This person will report to the SVP of R&D and will be responsible for overseeing the development novel LNP (lipid nanoparticle) systems for *in vivo* mRNA delivery to support our immuno-oncology and immunology efforts. The successful candidate must be able to work in a fast paced and highly dynamic biotech environment. Ideal candidate will be a leader and a great team player with excellent communication skills and effective, inspiring management style. Responsibilities Oversee the development of novel LNP compositionsImprove existing LNP formulationsManage company's LNP teamAdvance targeted LNP delivery with novel approaches for in situ mRNA deliveryOversee physicochemical characterization of LNP formulationsWork closely with internal teams and external collaborators and ensure delivery on key milestonesGuide company's RNA delivery strategy, with a particular emphasis on IP and key deliverablesStay up-to-date on RNA delivery literature and prepare technical reports and white papersPrepare technical documents and manuscripts for regulatory filings, IP prosecution, and publicationsPresent scientific findings internally and externally at scientific conferences and industry events Requirements PhD in chemical engineering, organic chemistry or a related field8-10 years of hands-on experience with lipid nanoparticle systems for mRNA and/or siRNA deliveryExperience with targeted LNPs and conjugation of biomaterialsExperience with analytical techniques for LNPs such as HPLC/UPLC, LC-MS, DLS, UV-Vis, fluorescence spectrophotometry, Ribogreen assay, gel electrophoresis, capillary electrophoresis, flow cytometry (CytoFLEX nano, NanoFCM) etc.Excellent communication skills (oral and written)Excellent record keeping skills (eLN)Startup mind-set (innovative, enthusiastic, team player, and problem solver)Willingness to learn, teach, and grow in a fast-pace environmentIndustry experience, strong management skills and basic knowledge of the drug development processesProficiency in design and characterization of novel lipids is a plus Benefits : Competitive 401(k)Highly competitive healthcare coverage (PPO/HMO)Free parking, monthly subway pass, or a subsidized commuter rail passFree Bluebike MembershipGym Membership SupportFlexible Spending AccountPaid parental leave, family caregiver leave, medical leavePaid life insurance coverageOn-site cafeteriaCompetitive vacation and sick days per year Kernal provides a diverse work environment and is committed to equal employment opportunities for all its employees and qualified applicants. We do not discriminate in employment practices for the race, color, national origin, age, gender, sexual orientation, marital or veteran status, religion, disability, or any other legally protected status. Kernal Bio will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law. Connected All roles at Kernal BiologicsMore Management / Director rolesRoles using HPLC/UPLCBiomaterials roles Related roles ME Associate Scientist, Postdoctoral Fellow – Device Development & TechnologyMerck Rahway, NJ BH Research and Technology Innovation ScientistBioLab Holdings, Inc. Mesa, AZ MG Research Lab Technician IMassachusetts General Hospital Boston, MA $60kUP Dental Materials Research Scientist, R&DUltradent Products, Inc. South Jordan, UT J& Spring 2027 Biomaterials Research Co-opJohnson & Johnson Warsaw, IN Common questions Where is the Director, LNP Formulation role at Kernal Biologics based? This role is based in Boston, MA. What degree is required for the Director, LNP Formulation role at Kernal Biologics? This role requires a PhD. How many years of experience does this Director, LNP Formulation role require? The posting calls for 8–10 years of relevant experience. What polymers or materials does this Director, LNP Formulation role work with? lipid nanoparticles, biomaterials. What techniques or methods are required for this Director, LNP Formulation role? HPLC/UPLC, LC-MS, DLS, UV-Vis, Ribogreen assay.