Director, LNP Discovery

Responsibilities

• Oversee the development of novel LNPs (e.g., lipid chemistry, composition, formulation process)
• Oversee the development of cell-based assays and animal models for LNP testing
• Lead LNP Delivery biology efforts, including protein design and bioconjugation to ensure successful LNP optimization
• Collaborate cross-functionally with pharmacology and programming teams to achieve key milestones
• Drive the company’s RNA extrahepatic delivery strategy, with a particular emphasis on IP and key deliverables
• Stay up to date on RNA delivery literature and prepare technical reports and white papers
• Prepare technical documents and manuscripts for IP filings and publications
• Present scientific findings internally and externally at key scientific conferences and industry events

Requirements

• PhD in Pharmaceutical Sciences, Biochemistry, Engineering, Chemistry, or related field
• 10+ years of experience with lipid nanoparticles, siRNA, and protein design
• Demonstrated experience successfully translating animal models from mouse to non-human primate
• Excellent communication skills (oral and written)
• Track record of innovation in LNP research, spanning bioconjugation, protein design and/or binder design
• Strict record keeping skills (eLN)
• Proven team leader with a track record of strong research team leadership
• Ability to synthesize various inputs and make recommendations on strategic approaches we can take as a company in the area of LNP research
• Ability to operate effectively in both detail and high-level settings and strength in navigating
• Ability to think strategically and influence others, and approach challenges with a proactive, ownership mindset

Qualifications

• Biotech Industry experience
• Knowledge of the drug development process

Skills

• Collaborative – Openness, One Team
• Undaunted – Fearless, Can-do attitude
• Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
• Entrepreneurial Spirit – Proactive. Ownership mindset

Benefits

The range provided is CRISPR Therapeutics' reasonable estimate of the base compensation for this role. The actual amount will be based on job-related and non-discriminatory factors such as experience, training, skills, and abilities.

Pay

$195,000 to $215,000+ bonus, equity and benefits

Schedule

Fully on-site