Director, Degrader Chemistry

About the role

Work in a highly collaborative and cross-functional team to develop antibody drug conjugates (ADCs). The position requires close collaborations with various functional teams, outside partners, CROs, and CDMOs in Cambridge, Massachusetts—a global life-science hub with dozens of research institutions, biopharmaceutical companies, and over 30 million square feet of laboratory space.

Responsibilities

• Participate in ADC research and development programs by providing chemistry know-how and expertise in protein degraders, molecular glues, payloads, and linkers.
• Design and synthesize protein degraders and molecular glues.
• Coordinate and collaborate with the CMC team supporting process development and GMP manufacturing.
• Prepare preclinical documents for IND filing.
• Work cross-functionally within the R&D organization.
• Collaborate with outside partners, CROs, and CDMOs.

Requirements

• Ph.D. or M.S. in organic chemistry or a related discipline with 8+ years of industry experience in drug discovery and development.
• Strong experience in protein degraders and molecular glues.
• Proven track record of creative thinking and consistent delivery as demonstrated by publication/presentation records.
• Highly organized with a proactive mentality.
• Thrive in a team-centered and collaborative environment.
• Excellent interpersonal, networking, and communication skills.

Preferred Qualifications

• Experience in ADC payload, linker, and conjugation chemistry.
• Experience in ADC manufacturing process development.

Benefits

• Medical, Dental, and Vision Insurance.
• Life, AD&D, and Critical Illness Insurance.
• Pre-tax HSA & FSA, DCRA Spending Accounts.
• Employee Assistance & Concierge Program (EAP) available 24/7.
• Parental and Childbirth Leave & Family Planning Assistance.
• Sitterstream: Virtual Tutoring & Childcare Membership.
• Paid Time Off: Vacation, Sick, Bereavement, Holidays (including Floating), and Year-End U.S. Shutdown.
• 401(K) Plan with Company Match.
• Tuition Reimbursement & Student Loan Assistance Programs.
• Wellbeing Incentive Platforms & Incentives.
• Professional Development Programs.
• Commuting Allowance and subsidized parking.
• Discounted Home, Auto & Pet Insurance.

Pay

Expected Pay Range: $168,100/year to $268,700/year plus benefits, annual bonus, and equity (bonus and equity are variable and dependent on company and individual performance).