Director, Degrader Chemistry

Cambridge, US | Full time

About the role

The ideal candidate will work in a highly collaborative and cross-functional team to develop antibody drug conjugates (ADCs). The position requires close collaborations with various functional teams, outside partners, CROs, and CDMOs.

Responsibilities

• Participate in ADC research and development programs by providing chemistry know-how and expertise in protein degraders, molecular glues, payloads, and linkers.
• Design and synthesize protein degraders and molecular glues.
• Coordinate and collaborate with CMC team supporting process development and GMP manufacturing.
• Prepare preclinical documents for IND filing.
• Work cross-functionally within the R&D organization.
• Collaborate with outside partners, CROs, and CDMOs.

Requirements

• Ph.D. or M.S. in organic chemistry or a related discipline with 8+ years of industry experience in drug discovery and development.
• Strong experience in protein degraders and molecular glues.
• Proven track record of creative thinking and consistent delivery as demonstrated by publication/presentation records.
• Highly organized with a proactive mentality.
• Thrive in a team-centered and collaborative environment.
• Excellent interpersonal, networking, and communication skills.

Preferred Qualifications

• Experience in ADC payload, linker, and conjugation chemistry.
• Experience in ADC manufacturing process development.

Benefits

• Medical, Dental, and Vision Insurance.
• Life, AD&D, Critical Illness Insurance.
• Pre-tax HSA & FSA, DCRA Spending Accounts.
• Employee Assistance & Concierge Program (EAP) available 24/7.
• Parental and Childbirth Leave & Family Planning Assistance.
• Sitterstream: Virtual Tutoring & Childcare Membership.
• Paid Time Off: Vacation, Sick, Bereavement, Holidays (including Floating) & Year-End U.S. Shutdown.
• 401(K) Plan with Company Match.
• Tuition Reimbursement & Student Loan Assistance Programs.
• Wellbeing Incentive Platforms & Incentives.
• Professional Development Programs.
• Commuting Allowance and subsidized parking.
• Discounted Home, Auto & Pet Insurance.

Pay

Expected Pay Range: $168,100/year to $268,700/year + benefits, annual bonus & equity (bonus and equity is variable and dependent on company and individual performance).

About the location

Home to dozens of research institutions, biopharmaceutical companies, life science incubators, venture capital firms, and over 30 million square feet of laboratory space, Cambridge, Massachusetts has earned a reputation as the #1 life science cluster in the world. As part of the Greater Boston area, the city is often referred to as the "biotech supercluster" due to its high concentration of life sciences firms. This unique ecosystem is the result of a model partnership between academia and industry, fostering collaboration and innovation and driving the development of new therapies, medical devices, and diagnostics.