Contract Cell Line Development (CLD) Scientist

About the role

Keros Therapeutics is seeking a highly motivated and collaborative individual to join our protein biochemistry group within our Research Department. Our group exploits multidisciplinary approaches in protein sciences and protein engineering, to better understand the biochemical, biophysical, and structural functional properties of the biomolecules within the TGF-β superfamily that drive the signaling pathway. Our efforts greatly contribute to advance innovative research and drug discovery and heavily support our discovery pipeline.

Responsibilities

• Perform mammalian cell line development activities, including transfection, selection, minipool and clone generation
• Establish efficient and scalable workflows for screening and evaluating cell lines and clones, troubleshooting as needed
• Develop, optimize and establish high-producing stable cell lines of potential new drug candidates such as recombinant proteins and antibodies
• Design and execute experiments to evaluate cell growth, productivity, stability, metabolic profiles, and product quality
• Contribute to routine mammalian expression of our therapeutic molecules through stable expression in CHO cells to support ongoing studies, as needed
• Perform assays and characterization techniques (SDS-PAGE and SEC-HPLC) to characterize R&D molecules
• Maintain clear, accurate documentation of computational and experimental laboratory work and summarize results as needed in study reports
• Communicate progress, results, and challenges effectively
• Provide updates at research meetings in both oral and written formats

Requirements

• A bachelor’s or master’s degree in biochemistry, chemistry, engineering or a related field with 8+ (Bachelor’s) or 5+ (Master’s) years of industrial experience in cell line development
• Extensive hands-on experience with protein expression in mammalian cells is required
• Strong hands-on experience with CHO cell line development activities is required
• Experience with high-throughput cell line development and/or clone screening is highly desirable
• Experience with mammalian expression in wave bioreactors and/or stirred tank bioreactors is highly desirable
• Familiarity with protein characterization techniques is a plus
• Experience working with wet lab benchwork, lab etiquette, pipetting, and volumetric handling
• Ability to perform chemical stoichiometric calculations and buffer preparation
• Ability to work as part of a cross-functional team, and independently with supervision
• Exhibit excellent communication and organization skills, detail-oriented, proficient in MS office, data analysis, and slide presentation
• Displays a high degree of maturity, honesty, trust, accountability and integrity

Qualifications

• Consider a scientific problem/question as an opportunity for innovation and intellectual growth

Skills

• Hands-on experience with protein expression in mammalian cells
• Experience with CHO cell line development activities
• Experience with high-throughput cell line development and/or clone screening
• Experience with mammalian expression in wave bioreactors and/or stirred tank bioreactors
• Familiarity with protein characterization techniques
• Experience working with wet lab benchwork, lab etiquette, pipetting, and volumetric handling
• Ability to perform chemical stoichiometric calculations and buffer preparation
• Ability to work as part of a cross-functional team, and independently with supervision
• Excellent communication and organization skills, detail-oriented, proficient in MS office, data analysis, and slide presentation

Benefits

Our benefits package includes:

• Comprehensive health insurance options
• Paid time off and holidays
• Flexible spending accounts
• Retirement savings plan
• Professional development opportunities

Pay

$95—$111 USD per hour or base annual full-time salary for all positions in the job grade within which this position falls. The actual base salary offer will depend on a variety of factors including experience, education, and other relevant factors.

Schedule

Full-time position