Computational Clinical Scientist II, Clinical Bioinformatics

About the role

In this role, you will work within our Translational Medicine group analyzing and interpreting molecular and clinical data. Analysis will focus on using genomic, protein, and other targeted assays to identify and validate predictive biomarkers.

The Computational Clinical Scientist will work on various projects in different phases of drug development and contribute to the cross-functional team, which includes other bioinformaticians, program leads, medical monitors, biostatisticians, and other pre-clinical scientists.

• Integrate multiple data sources including circulating tumor DNA, patient enrollment data, molecular profiling (RNA/DNA sequencing outputs), and multiplex immunohistochemistry to identify and validate new biomarkers for candidate drugs.
• Work with internal groups, contract research organizations, and collaborators to deliver validated biomarker data and analysis.
• Support the development of biomarker-related aspects of trial design where bioinformatic analysis is required, including study protocols, lab manuals, clinical study reports, and other regulatory documents.
• Work with biomarker scientists to support analysis of biomarker readouts (summary statistics and visualization of efficacy in molecular subgroups).
• Collaborate with preclinical bioinformaticians to design, analyze, and interpret experiments to validate biomarkers, understand compound mechanism of action, and identify biomarkers for patient selection and target engagement.

Requirements

• M.S. or Ph.D. in bioinformatics, biology, data science, or a related field with emphasis on biological data analysis.
• 2+ years of pharmaceutical or biotech experience in bioinformatics focused on oncology, immunology, or a related field.
• Proficiency and experience programming using R and/or Python.
• Proficiency in statistical models and analysis of clinical data.
• Experience with efficacy, baseline demographic, and other outcome data generated in a clinical trial.
• Experience with statistical methods such as survival analysis and causal inference.
• Expertise in bioinformatic analysis of cancer signaling pathways and driver mutations.

Skills

• Proficiency in visualizations and faceting of molecular data (oncoplots, heatmaps, PCA, etc.).
• Some machine learning experience is a strong plus.
• Experience with tools to analyze cancer genomics data types (RNA, WES, ctDNA, etc.) and common tool outputs (GATK, Salmon, OncoKB, VEP, etc.).
• Development with professional software development systems and methods (e.g., IDEs, ticketing systems, version control systems).
• Familiarity with large public/private genomic data sets (GDC, TCGA, etc.).
• Familiarity with clusters, containers, and cloud computing infrastructure for data processing, analysis, and storage.

Pay

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is $132,000 - $166,000 USD. The range displayed is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.