Computational Biology Post Doctorate Fellow, Biomarker Department

Summary

We are seeking a highly motivated and outstanding individual to join our Biomarker group as a Postdoctoral Fellow. The Biomarker group develops, supports, and implements the biomarker strategy to support the wholly owned Ionis pipeline. This individual will be working with external collaborators and cross-functional teams to access and analyze proteomic and EEG data to support biomarker identification for neurology programs.

Responsibilities

• Aggregating and harmonizing existing proteomic and EEG datasets
• Building and utilizing (coding) analysis pipelines (including using languages such as R and Python)
• Confirming findings in validation cohorts as well as with targeted assays
• Sharing relevant findings with stakeholders within Ionis as well as presenting data in team meetings and larger organizational meetings

Requirements

• Bioinformatician with PhD in computational biology or related field
• Experience handling EEG data is not required
• Critical-thinking and problem-solving skills with attention to detail
• Experience devising, designing, and executing scientific experiments and projects
• Expected experience includes working with multi-modal omics datasets and large proteomic datasets (O-link, untargeted LC-MS data, etc), evidenced by high-impact publications
• Proficiency in R, Python or another appropriate programming language for analysis of processed proteomics data (e.g. SomaScan, label-free or TMT mass spectrometry), including data wrangling, QC, normalization, and differential protein abundance testing
• Experience with packages such as tidyverse, MSstats, DEP2, pandas, numpy, and scikit-learn, as well as pathway and network analysis tools (e.g. GSEA/fgsea, clusterProfiler), is highly desirable
• The following experience would be beneficial but is not essential: Running assays such as targeted protein ELISAs to validate computational findings, Ability to multi-task and manage several projects in parallel, Work collaboratively and productively in fast-paced cross-functional teams, Excellent communicator who is comfortable presenting in cross-functional meetings and maintaining open and effective lines of dialogue, addressing problems and collaborating constructively with team members, Must be organized, adaptive, and detail oriented, with the ability to multitask, and manage multiple tasks in parallel with competing priorities, Proven ability of being productive and successful in an intense work environment

Preferences

• Candidate must be in San Diego or willing to relocate (fully onsite or hybrid)
• Travel minimal 0-10%

Additional Information

• Visit our website, http://www.ionis.com for more information about Ionis and to apply for this position
• Reference requisition # IONIS003876
• Ionis offers an excellent benefits package!
• Follow this link for more details: Ionis Benefits Full Benefits Link

Pay Scale

$65,000 to $87,000