Clinical Trial Manager, CKDSouth San Francisco, CA

About the role

At Maze Therapeutics, you’ll play a hands-on role in co-leading and driving the execution of our Chronic Kidney Disease (CKD) clinical trials. You’ll contribute to mid to late-stage clinical studies, work cross-functionally with internal teams and external partners, and ensure trials run efficiently and with the highest quality standards.

Responsibilities

• Steer the execution of one or more Phase 2 CKD clinical trials from protocol development to achievement of corporate and study milestones such as first patient in, interim analysis, database lock, and study report completion.
• Manage external vendors including CROs, additional key vendors, and global investigative sites.
• Ensure adherence to study protocols, SOPs, ICH GCP guidelines by overseeing monitoring activities at investigative sites.
• Coordinate the development of study materials such as CRFs, ICFs, patient diaries.
• Act as the voice of Clinical Operations on cross-functional teams, including the Study Execution Team (SET).
• Partner with Clinical Operations and Clinical Science Team to engage with therapeutic area KOLs and Investigators.

Requirements

• A degree in a scientific discipline or health related field.
• Minimum of 4 years clinical research experience, including 2 years as a Clinical Trial Manager at a biopharmaceutical company or CRO.
• Experience with planning and executing Phase I–II trials is preferred.
• Demonstrated proficiency in implementing, monitoring, and management of clinical trials, from start-up to close-out.
• General knowledge of FDA regulatory requirements and ICH GCP guidelines.
• Strong organizational skills, ability to prioritize and multi-task.
• Excellent verbal and written communication skills.
• Demonstrated problem-solving and negotiation abilities.
• Ability to work as part of a team and build strong working relationships with internal and external partners.
• Capacity to roll up sleeves to perform a broad range of clinical trial related tasks as needed.
• Willingness to travel as necessary, consistent with project needs.
• Excellent computer proficiency (Microsoft Office Suite, Project, Word, Excel, PowerPoint, Outlook).
• Experience with clinical trial databases (e.g., Medidata Rave, Veeva, etc.).

About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with kidney and metabolic diseases. Our clinical pipeline is anchored by two small molecule programs: MZE829, an APOL1 inhibitor for patients with APOL1‑mediated kidney disease, and MZE782, which targets genetic drivers of disease in phenylketonuria (PKU) and chronic kidney disease. We are also advancing a preclinical pipeline through our Compass platform, which links human genetic variants to the biological pathways that drive disease.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We foster a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

Our Core Values

• Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.
• Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.
• Stand True – Our integrity is foundational; it guides us no matter the obstacle.

Pay

The expected annual salary range for employees located in the San Francisco Bay Area is $143,000 – $175,000. Additionally, this position is eligible for an annual performance bonus. Maze performs position-based compensation benchmarking to industry market data to ensure competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Benefits

• Competitive medical, dental, and vision insurance
• Mental health offerings
• Equity incentive plan
• 401(k) program with employer match
• Generous holiday and PTO policy