Chemical Biologist, Discovery Sciences

About the role

In this role, you will explore emerging modalities in induced proximity, validate key mechanisms of action, align with therapeutically relevant targets, and help initiate new drug discovery programs. Working closely with scientific peers and cross-functional partners, you will design and execute innovative chemical biology strategies, generate high-quality data, validate targets and concepts, develop cellular assays to quantify proximity-driven biology, and support the characterization and optimization of candidates for advancement into the drug discovery portfolio.

Key responsibilities

• Design, optimize, and execute assays to quantify proximity-driven biology (e.g., degradation, stabilization, signaling rewiring, or protein–protein interactions)
• Apply chemical and genetic perturbation approaches in cells to evaluate small molecule on-target and off-target activities
• Design of phenotypic and target-based chemical and genetic screens to identify novel starting points for drug discovery
• Elucidate mechanism-of-action (MoA) of induced proximity modalities using biochemical, cellular, and omics-based approaches
• Maintain accurate and timely documentation of experimental data, analysis, and conclusions
• Translate experimental results into clear recommendations to inform program prioritization and go/no-go decisions
• Stay current with advances in induced proximity and chemical biology to inform experimental strategy and identify new opportunities
• Collaborate cross-functionally across Novartis research teams and global sites
• Innovative and cross-disciplinary chemical biology approaches to problem solving

Essential requirements

• Recent Ph.D. (within last 2 years) in chemical biology, systems biology, cell/molecular biology, biochemistry or a related field
• Hands-on experience with molecular and cellular biology techniques (e.g., gene perturbation, protein analysis, cell-based assays)
• Ability to analyze and interpret complex biological datasets
• Ability to work in an exploratory, fast-evolving research environment with shifting priorities
• Demonstrated curiosity and ability to apply creative problem-solving approaches to adapt and overcome scientific challenges
• Excellent communication and presentation skills across a broad range of topics and adapted to variety of audiences
• Demonstrated ability to collaborate effectively in team environments

Highly desirable requirements

• Experience with, or exposure to, chemical biology, induced proximity (including targeted protein degradation), compound profiling, and/or drug discovery

Pay

The salary for this position is expected to range between $98,700 and $183,300 USD Annually. The final salary offered is determined based on factors like, but not limited to, relevant skills and experience, and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Benefits

Your compensation will include a performance-based cash incentive and, depending on the level of the role, eligibility to be considered for annual equity awards.

To learn more about the culture, rewards and benefits we offer our people click here.

Why Novartis

Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together?

EEO Statement

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, sex, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status.