Biologics Process Research & Development, Associate Scientist
Biologics Process Research & Development (BPR&D) within our Company's Research Laboratories is on a mission to rapidly deliver biotherapeutics to patients by efficiently developing innovative, robust manufacturing processes and technologies. To achieve this, we work closely with colleagues in Discovery, Pre-clinical, Early Development, Analytical, Formulation, and Commercial Manufacturing while providing an inclusive environment for all. Beyond process development for pipeline biologics, we innovate and build next-generation biomanufacturing technologies, including continuous manufacturing, green and sustainable processes, and proprietary technology platforms. We actively publish and engage with the scientific community to influence the field.
The Biologics Process Development (BPD) group focuses on upstream and downstream bioprocessing. As an Associate Scientist in BPD, you will work with a collaborative team to design, develop, and execute robust processes for early- to late-stage biological products. You will apply scientific principles to solve challenging problems and contribute to areas such as biophysical, process, economic, and multivariate modeling, leveraging digital tools to enhance process design.
Responsibilities
- Contribute to the development of innovative and disruptive technologies for next-generation biologic manufacturing processes.
- Develop and characterize robust clinical processes capable of delivering multi-kilogram quantities of drug substance.
- Independently design and conduct experiments for individual unit operations using relevant operational parameters and analytical inputs.
- Integrate unit operations both physically and with relevant process control and monitoring platforms for concurrent operations.
- Collaborate across the department, process analytics, and other functional teams in both Research & Development and manufacturing to advance the biologics pipeline.
- Conduct laboratory-scale and/or pilot-scale studies to support scale-up and tech transfer of processes.
- Contribute to a safe and compliant laboratory work environment.
Requirements
- BS (or expected completion within 6 months of application) in Chemical/Biochemical/Biomedical Engineering, Biotechnology, Biochemistry, Microbiology, Structural Biology, or related fields.
- Scientific understanding of the engineering principles for recombinant protein production unit operations.
- Knowledge of aseptic technique, protein biophysical properties, and general protein laboratory practices.
- Strong passion and commitment to integrate science and innovation into biologics’ process development.
Skills
Required
- Bioprocesses
- Biotechnology
- Cell Cultures
- Centrifugation
- Chromatographic Techniques
- Cross-Functional Teamwork
- Data Analysis
- Downstream Process Development
- Evaluating New Technologies
- Experimentation
- Innovation
- Laboratory Scales
- Mammalian Cell Culture
- Membrane Filtration Systems
- Microbiology
- Molecular Microbiology
- Process Scale-Up
- Protein Biochemistry
- Protein Expression
- Protein Purifications
- Scientific Methods
- Structural Biology
- Technology Transfer
Preferred
- Experience with molecular biology, protein expression, mammalian cell culture, protein purification, biochemical engineering, or protein analytical technologies.
- Knowledge of statistical data analysis tools such as design of experiments and multivariate data analysis.
Pay
The salary range for this role is $71,900.00 - $113,200.00. An employee’s position within the salary range will be based on factors including, but not limited to, relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.
Benefits
- Medical, dental, vision healthcare, and other insurance benefits (for employee and family).
- Retirement benefits, including 401(k).
- Paid holidays, vacation, and compassionate and sick days.
More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.
Schedule
- Travel Requirements: 10%