Biologics Process Research & Development , Senior Scientist

Biologics Process Research & Development (BPR&D) within our Research Laboratories is on a mission to rapidly deliver biotherapeutics to patients by efficiently developing innovative, robust manufacturing processes and technologies. We work closely with colleagues in Discovery, Pre-clinical, Early Development, Analytical, Formulation, and Commercial Manufacturing while providing an inclusive environment. Beyond process development for pipeline biologics, we innovate and build next-generation biomanufacturing technologies, including continuous manufacturing, green and sustainable processes, and proprietary technology platforms. We actively publish and engage with the scientific community to influence the field.

Biologics Process Research & Development (BPR&D) includes three lab-facing technical functional areas: Process Cell Sciences (PCS), Upstream, and Downstream Process Development & Engineering. This role focuses on the Biologics Process Development (BPD) group, covering upstream and/or downstream bioprocessing opportunities.

Responsibilities

• Innovation: Develop innovative and disruptive technologies for next-generation biologic manufacturing processes. Apply rigorous scientific principles and data analyses to solve challenging problems related to robust, cost-effective processes.
• Experimental Design and Problem-Solving: Develop and characterize robust processes for delivering multi-kilogram quantities of life-changing medicines. Design and conduct lab and/or pilot-scale studies to support mechanistic understanding, scale-up, and transfer of processes to manufacturing.
• Collaboration and Effective Communication:
  • Work with a collaborative, cross-functional team of scientists and engineers to advance the biologics pipeline from early- to late-stage development.
  • Partner with groups in both research and manufacturing divisions.
  • Represent your functional area in cross-functional teams.
• Coaching and Mentoring: Train and mentor junior scientists in experimental design, execution, and data interpretation.
• Safety and Compliance: Contribute to a safe and compliant laboratory work environment.

Requirements

Minimum Education Requirements: Bachelor's Degree with 4 years, Master's Degree with 3 years, or PhD with 0+ years of relevant experience (or expected PhD graduation within 6 months from date of application) in Chemical Engineering, Biochemical Engineering, Biomedical Engineering, Biotechnology, Biochemistry, Biology, Microbiology, or related fields.

• A proven ability to design and execute hands-on lab and/or in silico experiments.
• Proficiency with statistical design and analysis tools.
• Excellent communication skills, ability to work in matrixed teams, and collaborate with cross-functional partners.
• A demonstrated ability to think critically with excellent problem-solving and troubleshooting skills.

Qualifications

In addition to the required skills, relevant experience is needed in either upstream and/or downstream bioprocessing:

• Upstream:
  • Knowledge of recombinant protein expression, metabolic pathways, biochemistry, and cell culture.
  • Understanding of basic bioreactor principles and mass transfer kinetics.
  • Understanding of cell & molecular biology.
• Downstream:
  • Sound scientific knowledge of protein properties and purification.
  • Understanding of unit operations such as chromatography, filtration, crystallization, precipitation, adsorption, and mixing.

Preferred Experience and Skills

• History of external presentations and/or publications in peer-reviewed journals.
• Data science, modeling, machine learning, and artificial intelligence; proficiency with programming languages.
• Evaluating and introducing novel technologies and analytical tools in process development and manufacturing.
• Knowledge of protein biochemistry, biophysics, conjugation techniques.
• Vector construction, genetic engineering, and systems biology.
• Knowledge of cell-line development for protein expression in mammalian systems and suspension cell culture.
• Hands-on experience with RNA and whole-genome (re)sequencing, and bioinformatics analysis.
• High-throughput experimentation using automation platforms.
• Familiarity with feed and media development for large-scale recombinant protein expression in mammalian systems.
• Knowledge of Quality by Design, Process Characterization, and Control Strategy development.

Pay

The salary range for this role is $117,000.00 - $184,200.00. An employee’s position within the salary range will be based on factors including, but not limited to, relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

Benefits

We offer a comprehensive package of benefits, including:

• Medical, dental, vision healthcare, and other insurance benefits (for employee and family).
• Retirement benefits, including 401(k).
• Paid holidays, vacation, and compassionate and sick days.

More information about benefits is available at Merck Compensation and Benefits.

Schedule

• Travel Requirements: 10%
• Relocation: Domestic relocation assistance available.
• VISA Sponsorship: Available for qualified candidates.