Associate Scientist/Scientist I, Bioconjugation - 1-Year Contract Position

About the role

Hexagon Bio is seeking a highly motivated Associate Scientist/Scientist I to join our Bioconjugation team. This laboratory-based role focuses on ADC conjugation, purification, and analytical characterization/QC to support our expanding ADC pipeline. You will work closely with biochemists, medicinal chemists, and cell biologists to generate high-quality materials that enable in vitro and in vivo studies of novel natural-product–based payloads.

Key Responsibilities

• Perform antibody-drug conjugation at milligram scale using a variety of linker chemistries and conjugation strategies
• Purification of conjugated antibodies via FPLC-based purifications (SEC, IEX, HIC and other chromatography-based methods) and diafiltration
• Optimize reaction conditions, monitor conjugation efficiency, and ensure consistency across production batches
• Execute analytical assays to assess ADC properties and quality, including: SEC, HIC, IEX, RP-HPLC, UV-Vis, LC-MS DAR determination, and endotoxin
• Collaborate with cell biology teams to ensure materials meet criteria for potency assays, in vitro MoA studies, and in vivo PK/efficacy/tolerability experiments
• Maintain detailed electronic laboratory notebooks
• Comply with safety policies and best laboratory practices
• Contribute to a collaborative, transparent, and mission-driven team culture

Requirements

• Ph.D. + 0 to 2 years of relevant experience, Master’s Degree + 3 to 5 years of relevant experience or Bachelor’s Degree + 6+ years of relevant experience in Biochemistry, Chemistry, Structural Biology, or related discipline with hands-on experience, preferably in protein sciences or related area
• Direct experience with ADC conjugation, protein purification, or analytical characterization is strongly preferred
• Hands-on experience with HPLC based analytical methods such as SEC, IEX, HIC, RP-HPLC, and UV-Vis
• Strong analytical and troubleshooting abilities
• Excellent organization, communication, and documentation skills
• Curiosity, initiative, and the ability to excel in a dynamic startup environment

What We Offer

• A flexible and dynamic work environment where you pave your own path
• “All Hands Meetings” provide an opportunity to share company and team updates
• Rapid career advancement for driven performers
• Access to scientific conferences throughout the year
• A range of amenities, courtesy of the Menlo Park Labs business park, including shuttle, gym, rock-climbing wall, pool, sauna, sports courts, cafe, bike lockers, and free EV charging stations
• Opportunities to engage with the Hexagon community through team-building events like our Hexagon Happy Hours and holiday parties