Associate Scientist or Scientist - Yen Lab/TGEn Group (Lipid Nanoparticle Formulation)

Job Responsibilities

• Perform studies to develop genome editing strategies for human hematopoietic stem cells (HSC).
• Design and execute IND-enabling experiments to characterize the pharmacology of a genome-edited human hematopoietic stem cell product to treat sickle cell disease.
• Characterize the efficacy, safety, and potency of the HSC cellular drug product in in vitro and xenotransplantation assays.
• Multicolor flow cytometry and FACS to sort hematopoietic populations of relevance.
• Develop experimental methods including RT-PCR, ddPCR, next-generation sequencing, and single-cell sequencing.
• Perform NGS library preparation and analysis of editing outcomes, on-target and off-target.
• Evaluate scale-up and close-system processes to ensure reproducibility of the drug product.
• Conduct exploratory research on developing novel in-vitro and in-vivo delivery strategies.
• Interact and collaborate with multidisciplinary teams to advance the program.
• Establish tracking and trending analyses of process development and pilot runs.
• Draft documentation (protocols, batch records, reports) to standardize and transfer process to GMP facility.
• Maintain regular and predictable attendance.
• Perform other related duties as assigned to meet the goals of the department and institution.

Requirements

• Bachelor’s degree in a relevant scientific area is required.
• Master’s or PhD degree in a relevant scientific area is highly preferred.
• 7 + years of research experience is required with a Bachelor’s degree.
• 5 + years of research experience is required with a Master’s degree.
• 2 + years of research experience is required with a PhD.
• Experience leading and supporting research experiments preferred.
• Experience in guiding and training other laboratory personnel preferred.
• Proven performance in earlier role/comparable role.

Qualifications

• Bachelor’s degree in a relevant scientific area is required.
• Master’s or PhD degree in a relevant scientific area is highly preferred.
• 8 + years of relevant post-degree work experience is required with a Bachelor's degree.
• 6 + years of relevant post-degree work experience is required with a Master's degree.
• 3 + years of relevant post-degree work experience is required with a PhD.
• Experience leading and supporting research experiments preferred.
• Experience in guiding and training other laboratory personnel preferred.
• Proven performance in earlier role/comparable role.

Skills

• Expertise in lipid nanoparticle-based delivery technologies.

Benefits

At St. Jude Children’s Research Hospital, talented faculty and staff work together and with colleagues worldwide to advance the research and treatment of pediatric cancer and other catastrophic diseases. We are seeking an outstanding, highly motivated, and creative Scientist to join Dr. Jonathan Yen's lab and the Therapeutic Genome Engineering (TGEn) group.

The ideal candidate will bring expertise in lipid nanoparticle-based delivery technologies. Come join TGEn to enGENEer concepts to cures!

Pay

$65,520.00 - $114,400.00 Scientist
$86,320.00 - $154,960.00 Associate Scientist

Schedule

This position is based in Memphis, TN; relocation assistance is available.