Associate Scientist III, CMC Analytical Development

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a commercial-stage biopharmaceutical company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. The company focuses on developing innovative drugs for diseases with a genetic basis, typically characterized by the overproduction of one or more proteins involved in disease. Arrowhead’s RNAi technologies enable addressing conditions across virtually any therapeutic area, including disease targets not otherwise addressable by small molecules and biologics. The company leads the field in bringing RNAi-based therapies to diseases outside the liver, with a clinical pipeline targeting the liver and lung, and a promising preclinical pipeline. Arrowhead’s headquarters is in Pasadena, CA, with research and development teams in Madison, WI, and San Diego, CA, and a state-of-the-art manufacturing facility in Verona, WI.

About the role

This position is in the Analytical Development (AD) Group within the CMC Manufacturing Organization. An Associate Scientist III will support method development and validation activities for new drug substances and drug products. They will also support testing required for GLP Toxicology and cGMP Clinical Trial material release, as well as stability studies. This position reports to either AD Management or Senior AD staff.

Responsibilities

• Know and adhere to cGMP policies and procedures and relevant SOPs
• Independently provide accurate analytical results in support of new and ongoing projects
• Independently meet project timelines and deliverables
• Perform testing of samples to support batch release and stability studies
• Perform portions of analytical techniques, such as HPLC, GC, FTIR, UV/Vis, LC/MS, KF, etc.
• Assist with the design and initiation for development of analytical methods and improvement of existing ones to support all stages of drug development
• Handle, analyze, and characterize chemicals, pharmaceuticals, and related organic molecules
• Evaluate and interpret scientific data and provide the significance of such
• Independently design and execute non-routine experiments
• Analyze data/results and interpret outcome of experiments and independently propose appropriate follow-up
• Compile data tables of results, certificates of analysis, and develop stability reports
• Write analytical test methods, protocols, and standard operating procedures
• Calibrate, maintain, and troubleshoot all analytical equipment

Requirements

• Bachelor’s in Chemistry (or related area of study)
• 4 years of experience working in a chemistry laboratory setting
• Familiar with analytical instrumentation, test methodology/validations, data acquisition systems, and cGMP policies and practices
• Ability to correctly analyze data/results and interpret outcome of experiments and propose appropriate follow-up
• Strong attention to detail
• Works well with others and in a team environment
• Can be flexible with changing priorities

Qualifications

• Master’s Degree (preferred)

Pay

Wisconsin pay range: $78,000–$90,000 USD

Benefits

Arrowhead provides competitive salaries and an excellent benefit package.