Associate Scientist I, CMC Analytical Development

About the Company

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a commercial-stage biopharmaceutical company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference (RNAi) mechanism to induce rapid, deep, and durable knockdown of target genes. RNAi is a natural pathway in living cells that inhibits gene expression, affecting protein production. Arrowhead’s RNAi-based therapeutics leverage this pathway to address diseases with a genetic basis, often characterized by protein overproduction.

The company’s RNAi technologies enable the potential treatment of conditions across virtually any therapeutic area, including disease targets not addressable by small molecules and biologics. Arrowhead leads the field in expanding RNAi applications beyond the liver, with a clinical pipeline targeting liver and lung diseases and a robust preclinical pipeline. Headquartered in Pasadena, CA, Arrowhead has research and development teams in Madison, WI, and San Diego, CA, along with a state-of-the-art manufacturing facility in Verona, WI.

About the Role

The Associate Scientist I will join the CMC Analytical Development team, supporting analytical testing for drug substance and drug product development. This role involves performing routine laboratory testing, assisting with analytical method development and qualification, and supporting release and stability testing for GLP toxicology studies and cGMP clinical trial materials.

This position offers the opportunity to learn analytical techniques in a collaborative laboratory environment while contributing to programs across multiple stages of drug development. The Associate Scientist I will work under the guidance of senior scientists and Analytical Development management.

Responsibilities

• Follow cGMP guidelines, laboratory procedures, and applicable SOPs.
• Perform routine analytical testing to support batch release, stability studies, and development activities.
• Assist with analytical method development, qualification, and validation activities.
• Learn and perform analytical techniques including HPLC, GC, FTIR, UV/Vis, LC/MS, Karl Fischer, and other laboratory instrumentation.
• Prepare samples, reagents, and standards for laboratory testing.
• Accurately document experimental procedures and results in laboratory notebooks and electronic systems.
• Compile data, prepare certificates of analysis, and assist with stability reports.
• Analyze experimental data with guidance from senior team members.
• Calibrate, maintain, and perform basic troubleshooting of laboratory equipment.
• Collaborate with cross-functional teams to meet project timelines and deliverables.
• Maintain a clean, organized, and safe laboratory environment.

Requirements

• Bachelor's degree in Chemistry, Biochemistry, Pharmaceutical Sciences, or a related scientific discipline.
• 0-2 years of laboratory experience (industry, academic research, internships, or co-op experience considered).
• Basic understanding of analytical chemistry principles and laboratory techniques.
• Familiarity with analytical instrumentation through coursework or laboratory experience.
• Strong organizational skills and attention to detail.
• Excellent written and verbal communication skills.
• Ability to work effectively both independently and within a collaborative team environment.
• Comfortable managing multiple priorities in a fast-paced environment.

Preferred Qualifications

• Experience working in a cGMP or regulated laboratory environment.
• Hands-on experience with chromatography or other analytical instrumentation.

Pay

Wisconsin pay range: $57,000 USD - $68,000 USD.

Benefits

Arrowhead provides competitive salaries and an excellent benefit package.