Jobs · OTHR · California

Associate Scientist II (Contract), Research

Vaxcyte · San Carlos, CA · 2 wk ago
OTHRContract

Essential Functions

  • Execute the following AKTA FPLC chromatography techniques:
  • Immobilized metal affinity chromatography (IMAC)
  • Ion-exchange chromatography (IEX)
  • Hydrophobic interaction chromatography (HIC)
  • Size-exclusion chromatography (SEC)
  • Hydroxyapatite (CHT / HA)

Requirements

  • BS in Biochemistry, Molecular Biology or a relevant science considered, with minimum of 2 years of relevant industry experience or MS with minimum of 1 year of relevant industry experience.
  • Experience with diverse protein targets, bacterial and eukaryotic recombinant proteins, small/large subunit vaccine antigens, fusion proteins, multimeric complexes, glycoproteins, and VLPs.
  • The role requires demonstrated success with alternative capture/polishing methods and orthogonal cleaning strategies appropriate for potential vaccine antigens.
  • PREFERRED: Experience with Cell-free protein synthesis system.
  • Familiarity with automation or high throughput workflows such as (96-well plates) and UNICORN/AKTA software DoE integrations.
  • Experience in process development.
  • Strong interpersonal skills to collaborate well within the team and excellent written and verbal communication skills.

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