Associate Scientist I, In Vivo Research

Arrowhead Pharmaceuticals, Inc. (Nasdaq: ARWR) is a commercial-stage biopharmaceutical company developing medicines that treat intractable diseases by silencing the genes that cause them. Using a broad portfolio of RNA chemistries and efficient modes of delivery, Arrowhead therapies trigger the RNA interference mechanism to induce rapid, deep, and durable knockdown of target genes. RNA interference, or RNAi, is a natural cellular process that inhibits gene expression, affecting protein production. Arrowhead’s RNAi-based therapeutics leverage this pathway to address diseases with a genetic basis, often characterized by protein overproduction. The versatility of our RNAi technologies enables us to target conditions across therapeutic areas, including those not addressable by small molecules or biologics. Arrowhead leads the field in expanding RNAi applications beyond the liver, with a clinical pipeline targeting liver and lung diseases and a robust preclinical pipeline. Headquartered in Pasadena, CA, Arrowhead has research and development teams in Madison, WI, and San Diego, CA, and a state-of-the-art manufacturing facility in Verona, WI.

About the role

The Associate Scientist will join the In Vivo Pharmacology team within the Biology Department at our Madison, WI, site. This role supports the discovery, development, and translation of novel drug targets through in vivo studies and preclinical model development.

Responsibilities

• Perform in vivo studies to facilitate drug discovery and development across various diseases.
• Establish new preclinical animal disease models.
• Conduct animal behavior studies as needed.
• Coordinate processes across departments and with external vendors to ensure efficient study execution and data generation.
• Apply relevant scientific literature to troubleshoot and solve project challenges.
• Present research findings to project teams and prepare technical reports.
• Maintain high productivity in the lab and perform critical experiments.

Requirements

• Bachelor’s degree in Biology or a related field with some experience in small animal handling (e.g., test article administration, tissue collection) OR an Associate Degree in a related field with 7 years of relevant experience.
• 2+ years of extensive experience with small animal handling.
• Strong record-keeping skills and experience in data analysis, graphing, and presentation.
• Ability to work independently, manage multiple projects, and meet deadlines.
• Demonstrated innovation, creativity, and resilience in problem-solving.
• Excellent oral and written communication skills.
• Self-motivated team player who thrives in a fast-paced, multidisciplinary, matrixed environment.

Preferred Qualifications

• Experience in preclinical disease model development for drug discovery.
• Proficiency in animal dose administration and surgical procedures.

Pay

Wisconsin pay range: $55,000–$68,000 USD.

Benefits

Arrowhead provides competitive salaries and an excellent benefits package.