Associate Researcher II - Hematology & Medical Oncology

About the role

The Associate Researcher II will work in the laboratory of Hanna Irie and will be engaged in translational breast cancer research projects focused on regulators of growth, survival and drug resistance, as well as the tumor microenvironment. The researcher will use a broad range of approaches (genetic, cell biological and in vivo modeling) to understand how breast cancers, particularly triple‑negative breast cancers, resist chemotherapy treatments and metastasize. Projects also examine novel mechanisms that contribute to the growth and metastases of triple‑negative breast cancers. The researcher will utilize patient‑derived xenograft models of breast cancer and organoid cultures to screen and validate novel therapeutic strategies in collaboration with chemical biologists, and will study how the immune microenvironment regulates response of breast and other cancers to chemotherapy/targeted therapies. The role includes designing and conducting experiments, maintaining accurate records, and contributing to overall laboratory maintenance.

Responsibilities

• Conduct experiments using advanced research techniques specific to the subject matter of the research project.
• Analyze and assist in interpreting moderately complex results.
• Perform assays to support research studies.
• Assist in new and unexpected research experiments and techniques.
• Assist in the collection, analysis and review of experimental data for publication and presentation.
• Perform other related duties as needed.

Technical duties

• Cell culture
• Western blot
• Cell viability assays
• qPCR
• DNA preparation (bacterial transformation, DNA extraction, transfection)
• Lentivirus production
• Mouse handling – tumor cell injections, mouse surgeries, IVIS imaging
• Flow cytometry
• Organoid development and culture
• Microscopy
• Lab record keeping
• Contribute to laboratory maintenance

Qualifications

• Bachelor’s degree in sciences or related field, or equivalent experience, with 2 years in a research environment; or a Master’s degree with 2 years of wet‑bench laboratory experience (strongly preferred).
• Background in cell biology/models, genetics, molecular biology, biochemistry, or immunology (preferred).
• Experience with mouse tumor models and related procedures (handling, tumor cell injection, flow cytometry, mouse surgical procedures, IVIS imaging) (strongly preferred).

Employer description

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees across eight hospitals, 400+ outpatient practices, 300+ labs, a school of nursing, and a leading school of medicine and graduate education. The system advances health for all people by discovering and applying new scientific knowledge, developing safer, more effective treatments, educating the next generation of medical leaders, and supporting local communities. It includes more than 9,000 physicians, multiple outpatient surgery centers, and affiliated community health centers, and is consistently ranked among the nation’s top hospitals.

Pay

The salary range for this role is $66,482.07 – $84,560 annually. Actual compensation depends on experience, education, and operational need; the range does not include bonuses, differential pay, or other forms of compensation.