Associate Researcher II - Hematology & Medical Oncology

About the role

The Associate Researcher II will work in the laboratory of Hanna Irie and will be engaged in translational breast cancer research projects focused on regulators of growth, survival and drug resistance, as well as the tumor microenvironment. The researcher will use a broad range of approaches (genetic, cell biological and in vivo modeling) to understand how breast cancers, particularly triple‑negative breast cancers, resist chemotherapy treatments and metastasize. The projects also examine novel mechanisms that contribute to the growth and metastases of triple‑negative breast cancers. The researcher will utilize patient‑derived xenograft models of breast cancer and organoid cultures to screen and validate novel therapeutic strategies in collaboration with chemical biologists. The researcher will also study how the immune microenvironment regulates response of breast and other cancers to chemotherapy/targeted therapies. The researcher will be expected to design and conduct experiments, be responsible for accurate record keeping and contribute to overall maintenance of the laboratory.

Responsibilities

• Conduct experiments using advanced research techniques specific to the subject matter of the research project.
• Analyze and assist in interpreting moderately complex results.
• Perform assays to support research studies.
• Assist in new and unexpected research experiments and techniques.
• Assist in the collection, analysis and review of experimental data for publication and presentation.
• Perform other related duties as needed.

Technical Duties

• Cell culture
• Western blot
• Cell viability assays
• qPCR
• DNA preparation (bacterial transformation, DNA extraction, transfection)
• Lentivirus production
• Mouse handling – tumor cell injections, mouse surgeries, IVIS imaging
• Flow cytometry
• Organoid development and culture
• Microscopy
• Lab record keeping
• Contribute to laboratory maintenance

Qualifications

• Bachelor’s degree in sciences or related field, or equivalent experience; or 1 year plus a Master’s degree in sciences or related field.
• 2 years in a research environment (or 2 years of wet‑bench laboratory experience strongly preferred).
• Background in cell biology/models, genetics, molecular biology, biochemistry, or immunology preferred.
• Experience with mouse tumor models and related procedures (handling, tumor cell injection, flow cytometry, mouse surgical procedures, IVIS imaging) strongly preferred.

Employer Description

Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 48,000 employees working across eight hospitals, over 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. The system advances health for all people by discovering and applying new scientific knowledge, developing safer and more effective treatments, educating the next generation of medical leaders, and supporting local communities with high‑quality care. Through integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health‑care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment.

Compensation

Salary range: $66,482.07 – $84,560 annually. Actual salaries depend on experience, education, and operational need. The listed range does not include bonuses, incentive, differential pay, or other forms of compensation or benefits.