Associate Director, Translational Medicine Lead, Antibody-Drug Conjugates

About the role

Do you feel passionate about the possibilities of great science changing lives of cancer patients? Do you have a background within oncology and/or translational research and have interest in working with antibody drug conjugates (ADCs) and an exciting portfolio? If so, this may be the role for you.

Responsibilities

• Delivering translational science and biomarker strategies for early and late development oncology assets through Ph1 to Ph 3 clinical studies based on the best available science and technologies.
• Generating disease linkage data to guide indication selection and targeted patient populations.
• Making sure target engagement and pharmacodynamic biomarkers are measured reliably and quantifiably to advise clinical decisions for selecting therapeutically relevant doses and schedules.
• Understanding key cancer pathway interactions, feedback mechanisms, and features of tumor microenvironment in clinical samples to guide rational drug combinations.
• Defining novel mechanisms of resistance targeted therapies by studying tumors at relapse.
• Influence translational strategy across the AZ portfolio.
• Collaborate with Oncology Research, Translational Medicine, and global product development teams to facilitate appropriate incorporation of Translational Medicine strategies for molecules in early to late phases of development in Oncology.
• Collaborate with clinical operations and clinical teams to define sample collection, lab manuals and clinical study protocols, and biomarker analyses in clinical studies related to oncology.
• Contribute to and ensure the quality of Translational Medicine clinical study reports, data reviews and interpretations, presentations, scientific publications and recommendations to development teams and management.
• Lead internal and external research collaborations in areas of clinical technologies and oncology translational research.

Requirements

• PhD and/or MD with experience in oncology drug development.
• A minimum of 5 years’ of relevant experience.
• In-depth knowledge of oncology disease area biology (solid tumors) and translational science.
• Ability to drive, manage, execute and deliver results for complex multi-functional projects.
• Highly developed problem solving and risk management skills, and attention to detail.
• Highly developed collaborative working skills.
• Ability to act as an external ambassador and to influence external organizations to enhance the image and reputation of AstraZeneca.
• Proven ability to motivate and develop others.

Qualifications

• Expertise in antibody drug conjugates.

Skills

• Strong scientific background in oncology.
• Experience in biomarker development and clinical trial design.
• Excellent communication and collaboration skills.
• Ability to work independently and as part of a team.
• Knowledge of regulatory requirements and guidelines.

Benefits

• Annual base pay range: $138,392 - $207,589.20 USD.
• Short-term incentive bonus opportunity.
• Equity-based long-term incentive program (salaried roles).
• Retirement contribution (hourly roles).
• Commission payment eligibility (sales roles).
• Benefits include: qualified retirement program [401(k) plan], paid vacation and holidays, paid leaves, and health benefits including medical, prescription drug, dental, and vision coverage.