Associate Director Therapeutic Area Genetics (Immunology)

About the role

We are looking for an extremely talented Scientist to join our Immunology Therapeutic Area Genetics (TAG) team. Within the RGC, the Immunology TAG team is using large-scale human exome sequencing for discovery and validation of new therapeutic targets in autoimmune and other immune-mediated disease.

Responsibilities

• Understand and leverage RGC and Regeneron datasets, external resources, and the scientific/medical literature to generate research questions and then generate relevant phenotypes from longitudinal clinical data.
• Design and execute genetic association studies.
• Perform integrative omics analyses to address these research questions.
• Deploy computational methods to integrate genetic data with multiple omics data to more effectively identify/prioritize drug targets illuminated by genetic association data.
• Collaborate with various RGC teams and with pre-clinical and clinical development teams at Regeneron to catalyze therapeutic development for genetically-validated targets in immunologic diseases.
• Work closely with other members of the Immunology and other TAG teams, Analytic Genetics, Sequencing, and GIDE in cross-functional initiatives within the RGC and Regeneron.
• Summarize insights of investigations into a variety of formats (e.g. documents, presentations, patent applications, publications, etc.) for audiences with broad backgrounds.
• Partner with Clinical Development to evaluate clinical stage programs and opportunities for human genetics studies to aid in the selection of indications or evaluation of safety considerations.

Requirements

This role requires 4 days per week onsite at our campus in Tarrytown, NY. This is not available as a fully remote / hybrid work.

Qualifications

• PhD, MD preferred with 8+ years of experience in the use of WES/GWAS datasets, RNA-Seq, proteomics and other large-scale platforms for genomic/proteomics.
• Demonstrated expertise in immunobiology, genetics, and mechanisms.
• Familiarity with large genetic studies that deliver novel genetic findings and medically relevant gene discoveries.
• Demonstrated ability to manage and collaborate in a multi-disciplinary team, to discover and evolve immunology-related drug discovery pipelines.

Skills

• Innovative thinking to human genetics and epidemiological studies.
• Leading complex human genetics research incorporating different analytic methods, phenotypes, and study designs.
• Ability to use medical knowledge to define relevant phenotypes for genetic association studies and to formulate innovative and important research questions.
• Understanding of drug development and clinical trial design and execution.

Benefits

Salary Range (annually): $176,100.00 - $287,300.00