Associate Director - QSP Quantitative Systems Pharmacology

At Sanofi, a global health care and pharmaceutical company, modeling and simulation approaches support strategy and critical decision making throughout the various phases of drug development. The Disease Modeling (DM) group at Sanofi is part of the Quantitative Pharmacology department within the Translational Medicine Unit in the R&D organization. We are seeking an experienced Quantitative Systems Pharmacology (QSP) Modeler to develop and apply mechanistic, multiscale models that inform drug discovery and development decisions across the R&D pipeline.

About the role

The successful candidate will independently lead QSP modeling efforts, integrate diverse biological and clinical data, and translate model insights into actionable recommendations for project teams. This role partners closely with research, quantitative pharmacology, and clinical stakeholders to enable model-informed decision making. The position is based in Morristown, NJ and focuses on designing, building, and applying QSP modeling approaches to support decision making within the neurology therapeutic area.

Responsibilities

• Interface with project teams to align modeling and simulation (M&S) needs and develop QSP strategy to address those needs.
• Develop and implement innovative mechanistic modeling strategies to support project team M&S needs.
• Communicate modeling predictions to key stakeholders to inform strategy and decision-making.
• Identify and interpret preclinical and clinical data critical for model development and refinement.
• Stay current with advances in systems pharmacology, disease modeling, and regulatory expectations for model-informed drug development.
• Contribute to abstracts and manuscripts.
• Perform job duties independently with minimal supervision and mentor others to develop similar capabilities.

Qualifications

• Ph.D. in Biomedical Engineering, Applied Mathematics, Systems Biology/Pharmacology, or related fields.
• 6+ years of hands-on QSP modeling experience in the pharmaceutical or biotechnology industry, with demonstrated impact on R&D programs.
• Track record of productivity, with evidence of independence in leading scientific projects.
• Strong publication record in QSP modeling commensurate with experience.
• Hands-on experience with programming languages like Matlab, R, or Julia (Matlab preferred).
• Demonstrated experience using QSP models to directly influence go/no-go decisions and competitive differentiation within a pharma setting.
• Deep understanding of disease biology within at least one therapeutic area and experience applying QSP across multiple programs or drug modalities.
• Experience working with heterogeneous datasets, including preclinical and clinical data.
• Experience with best practices for reproducible, well-documented modeling workflows.
• Proven ability to lead modeling workstreams and clearly communicate quantitative insights to scientific and non-scientific stakeholders, tailoring complexity to the audience.
• Experience mentoring junior scientists.

Skills

• Understanding of neurology, neuroinflammation, and neurodegeneration (desirable but not essential).
• Exposure to regulatory interactions or documentation involving modeling and simulation (desirable but not essential).

Benefits

• Discover endless opportunities to grow your talent and drive your career, whether through promotion or lateral moves, at home or internationally.
• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.
• Take good care of yourself and your family with a wide range of health and wellbeing benefits, including high-quality healthcare, prevention and wellness programs, and at least 14 weeks’ gender-neutral parental leave.