Associate Director - QSP Quantitative Systems Pharmacology

Main Responsibilities

• Interface with project team in aligning M&S needs and develop QSP strategy to address needs.
• Develop, and implement innovative mechanistic modeling strategies to support project team M&S needs.
• Communicate modeling predictions to key stakeholders to inform strategy and decision-making.
• Identify and interpret preclinical and clinical data critical for model development and refinement.
• Stay current with advances in systems pharmacology, disease modeling, and regulatory expectations for model-informed drug development.
• Contribute to abstracts and manuscripts.

About You

• Ph.D. in Biomedical Engineering, Applied mathematics, Systems Biology/Pharmacology or related fields.
• ≥6 years of hands-on QSP modeling experience in the pharmaceutical or biotechnology industry, with demonstrated impact on R&D programs.
• Strong publication record in QSP modeling commensurate with experience.
• Hands-on experience with programming languages like Matlab/R/Julia (Matlab preferred).
• Demonstrated experience creating and using QSP models to directly influence go/no-go decisions, and competitive differentiation within pharma setting.
• Deep understanding of disease biology within at least one therapeutic area and experience applying QSP across multiple programs or drug modalities.
• Experience working with heterogeneous datasets, including preclinical, and clinical data.
• Experience with best practices for reproducible, well-documented modeling workflows.
• Proven ability to lead modeling workstreams.
• Proven ability clearly communicate quantitative insights to scientific and non-scientific stakeholders, tailoring complexity to the audience.

Preferred Experience

• Mentoring junior scientists.
• Understanding of neurology, neuroinflammation and neurodegeneration.
• Exposure to regulatory interactions or documentation involving MIDD.