Associate Clinical Analyst II (US)

GeneDx (Nasdaq: WGS) delivers personalized and actionable health insights to inform diagnosis, direct treatment, and improve drug discovery. The company is uniquely positioned to accelerate the use of genomic and large-scale clinical information to enable precision medicine as the standard of care. GeneDx is at the forefront of transforming healthcare through its industry-leading exome and genome testing and interpretation services, fueled by the world’s largest, rare disease data sets.

About the role

This entry-level role supports the interpretation of genetic findings and contributes to accurate diagnosis and case resolution through exome and genome sequencing. The Associate Clinical Analyst II focuses on building foundational clinical analysis skills by assisting with case reviews under supervision, performing routine data interpretation tasks, and ensuring timely documentation and quality standards.

Responsibilities

• Perform clinical data analysis and case management to accurately interpret genetic findings.
• Establish phenotype-genotype correlations across diverse genetic disorders.
• Investigate and interpret clinical features of genetic conditions using internal resources and professional tools.
• Review and finalize genetic test reports, interpret variants, and curate internal databases.
• Serve as a subject matter expert for designated genes, disorders, tests, and workflows.
• Communicate with clients via email, phone, or other channels to support case resolution and provider engagement.
• Abstract clinical information from patient records as needed.
• Perform literature reviews and database searches to support variant interpretation and classification.
• Meet or exceed productivity and error standards as assigned by team lead.
• Document evidence and rationale for variant classification in a clear, standardized format.
• Assist with development of variant-, gene-, or disease-specific test information and report language.
• Perform other duties as assigned to support the team or department.

ABMGG Certified:

• Fulfill responsibilities of Clinical Consultant as defined by CLIA (42 CFR 493.1457), including:
  • Provide timely consultation to ordering providers regarding test selection, interpretation, and clinical correlation of laboratory results.
  • Review and ensure laboratory reports meet CLIA and CAP requirements for accuracy, completeness, and clinical relevance.
  • Approve and sign off on high-complexity test results in accordance with CLIA regulations.

Requirements

• PhD in Biology, Genetics or related field, or MD or DO with more than 2 years directly relevant experience in clinical diagnostics (including fellowship).
• Excellent verbal and written communication skills.
• Demonstrated computer skills, including ability to maintain high proficiency with internal systems and Microsoft Office Suite and the Office 365 environment.
• Prior experience with variant curation is preferred but not required.
• ABMGG certification or equivalent, certified in at least one specialty or board eligible.

Work Environment

This is a fully remote position. The employee will work from a home office or other suitable remote location with reliable high-speed internet access. Work is performed in a climate-controlled environment using standard office equipment including computer, phone, and video conferencing tools. Your standard work schedule and hours will be established in collaboration with your leader and may be adjusted to align with evolving business needs.

Physical Demands

• Sitting for extended periods (up to 8 hours per day).
• Repetitive use of hands and fingers for typing and mouse operation.
• Visual acuity for reading computer screens and documents.
• Ability to communicate effectively in person, by phone, and via video.
• Occasional standing, walking, and reaching for files or supplies.
• Occasional lifting of up to 15 pounds (files, office supplies, equipment).
• Ability to commute to office location as required.

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions of this position.

Schedule

Tuesday–Saturday or Sunday–Thursday, 9am–5pm ET.

Pay

$150,000—$165,000 USD

Benefits

At GeneDx, we provide competitive compensation and benefits that reflect local market practices and legal requirements in each country where we operate, helping employees thrive both professionally and personally.

Culture

At GeneDx, we’re driven by urgency and purpose: helping patients get diagnosed earlier. Our mission, to empower everyone to live their healthiest life through genomics, drives our team to make a tangible impact each day – and shapes our culture where high standards, strong teamwork, and meaningful ownership are the norm. We act with intention, support one another, and deliver work we’re proud to put our names on. Here’s what you can expect day to day:

• Play like a champion (step up, redefine what’s possible, own it): We bring energy, focus, and a bias for action. We step up, take initiative, and deliver on our commitments – with quality, speed, and care.
• Think bigger (stretch beyond, courage not consensus): We push past the obvious. We challenge assumptions, raise the bar, and make thoughtful, decisive calls — choosing progress over perfection.
• Grow fast (be curious, speak up, be agile): We stay curious, ask questions, and share direct feedback with respect. We adapt quickly and keep learning through collaboration and continuous improvement.

If you’re motivated by meaningful work, a fast-moving environment, and teammates who care deeply about outcomes, you’ll thrive at GeneDx.