VP, Scientific IT Business Partner
for section headings like About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule. We must include only sections that have real specific content. The posting includes responsibilities (Key Responsibilities with subpoints). It includes Qualifications (Education, Experience). It does not mention Benefits, Pay, Schedule explicitly. So we should not create those sections. Also maybe "Skills" not explicit separate; but could be part of Qualifications. We'll include About the role (overview), Responsibilities, Qualifications. Possibly also "Skills" if we can extract from responsibilities? Better not to invent. We'll follow instruction: include a section ONLY when posting has real, specific content for it. So we will have About the role (company description + role overview), Responsibilities (list of key responsibilities), Qualifications (Education and Experience). Use - for any list of duties/requirements/benefits. For prose use
. We must not repeat job title as heading. No Job ID etc. Remove boilerplate. So we need to extract substantive content.
Let's craft About the role: combine company description and role overview paragraphs before "Key Responsibilities". That includes: Madrigal is a biopharmaceutical company... The Vice President, Scientific IT Business Partner will lead... etc up to "This is a senior IT leadership role that requires deep life sciences technology experience, strong executive influence, and the ability to operate across strategy and execution." That's the overview. We'll put that in
maybe multiple paragraphs.
Responsibilities: list from "Key Responsibilities" bullet points. There are several categories with sub-bullets. We'll flatten into a list of responsibilities. Could keep sub-bullets as nested
but instruction says use - for any list of duties/requirements/benefits. Could do top-level
with each responsibility as - . Might include subpoints as separate
- as well. We'll just list each bullet point as
- . Ensure we preserve all substantive information.
Qualifications: Education and Experience sections. We'll list Education bullet points (Bachelor's degree required, Advanced degree preferred, Equivalent combination...). Experience bullet points (Typically requires 20+ years..., Significant experience..., Demonstrated experience..., Strong understanding..., Experience leading..., Experience building..., Experience managing..., Experience operating..., Experience with leading...). We'll put each as
- .
We must not include Benefits, Pay, Schedule.
Let's craft HTML.
We'll start with maybe not required; just output fragment. Use
headings.
Thus:
About the role
Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. The Vice President, Scientific IT Business Partner will lead Madrigal’s Scientific IT Business Partnership, supporting the company’s Research & Development and Technical Operations organizations. This role will serve as the senior IT partner to the R&D and TechOps executive leadership teams, translating functional strategy into technology roadmaps, portfolio priorities, operating capabilities, and delivery outcomes. As Madrigal continues to grow, the technology needs across R&D and TechOps are becoming more complex, interconnected, and critical to the company’s ability to execute. This leader will help mature how IT supports the scientific value chain, bringing both domains together with a breadth to lead across an interconnected landscape, ensuring the right systems, data, integrations, processes, partners, and internal capabilities are in place to support clinical development, regulatory progression, quality, manufacturing, supply, and continued operational scale. This is a senior IT leadership role that requires deep life sciences technology experience, strong executive influence, and the ability to operate across strategy and execution.
Responsibilities
- Serve as the senior IT business partner for Madrigal’s R&D and TechOps organizations, building trusted relationships with the respective ELT members and their leadership teams.
- Translate R&D and TechOps business strategies into multi-year technology roadmaps, investment priorities, and portfolio plans.
- Develop sufficient digital breadth across the scientific value chain to anticipate cross functional implications and ensure technology decisions made within one domain support the broader R&D and TechOps strategy.
- Provide strategic technology guidance across the scientific value chain, including clinical development, regulatory, quality, manufacturing, supply chain, CMC, and related scientific business capabilities.
- Partner with business leaders to identify opportunities where technology, data, automation, and AI can improve speed, quality, compliance, visibility, and decision-making.
- Represent R&D and TechOps needs within ITLT and enterprise governance forums, ensuring scientific priorities are visible, well-understood, and appropriately sequenced.
- Navigate competing priorities across R&D and TechOps, facilitating balanced recommendations that align with enterprise and corporate objectives.
- Own the Scientific IT portfolio across R&D and TechOps, including roadmap development, investment planning, prioritization, and value realization.
- Maintain an integrated view of technology needs, investments, dependencies, and risks across the scientific value chain.
- Partner with PMO and IT leadership to ensure initiatives are appropriately scoped, sequenced, resourced, governed, and delivered.
- Develop clear business cases for technology investments, including expected value, risk, implementation approach, resource needs, and long-term operating implications.
- Make start / stop / sequence recommendations for Scientific IT initiatives based on business value, risk, capacity, dependencies, and strategic alignment.
- Ensure Scientific IT roadmaps are realistic, integrated, and aligned with enterprise architecture, data strategy, cybersecurity, infrastructure, and compliance expectations.
- Provide executive-level visibility into portfolio health, delivery risks, resource constraints, and key decisions needed to keep work moving.
- Lead IT partnership and delivery for R&D functions, with near-term emphasis on Clinical Development and Regulatory capabilities.
- Support the continued buildout of Madrigal’s R&D technology landscape, including systems and capabilities that enable clinical execution, regulatory operations, scientific collaboration, data flow, inspection readiness, and decision-making.
- Bring strong working knowledge across R&D technology domains, while leveraging and growing internal and external subject matter expertise where deeper specialization is required.
- Partner with R&D leaders to identify technology needs across the development lifecycle and translate those needs into practical, scalable solutions.
- Connect technology decisions across Clinical, Regulatory, Safety, Data and other R&D capabilities to reduce fragmentation and create an integrated scientific technology landscape.
- Ensure R&D technology investments support clinical operations, regulatory milestones, data quality, compliance, and business agility.
- Strengthen internal ownership of critical R&D technology capabilities that require business context, continuity, and close alignment with scientific priorities.
- Lead IT partnership and delivery for TechOps functions, including CMC, Quality, Manufacturing, Supply Chain, and related operational capabilities.
- Apply broad understanding of the TechOps technology landscape while drawing on specialized expertise across Quality, Manufacturing, Supply Chain, CMC and other domains as needed.
- Build trusted relationships with TechOps leaders to understand business priorities, operational risks, external partner dependencies, and technology needs.
- Help mature the TechOps technology roadmap as Madrigal scales its manufacturing, quality, supply, and product lifecycle capabilities.
- Provide strategic oversight of across systems and capabilities such as QMS, LIMS, ERP, serialization, supply planning, quality documents, deviation / CAPA / change control, batch records, external manufacturing portals, and related manufacturing or quality systems.
- Identify opportunities to improve visibility, data flow, process consistency, and decision-making across internal teams and external manufacturing / supply partners.
- Lead the Scientific IT Business Partnership organization and ensure it can scale with the evolving needs of R&D and TechOps.
- Build and evolve the Scientific IT organization with the right combination of domain depth and cross functional breadth, ensuring specialized expertise is available where required while maintaining an integrated view across the scientific value chain.
- Own the Scientific IT application portfolio across R&D and TechOps, including lifecycle management, roadmap alignment, enhancement planning, operational support, and continuous improvement.
- Establish a clear service delivery model for Scientific IT, including support expectations, ownership, escalation paths, vendor responsibilities, performance management, and business continuity.
- Partner with Quality, IT Compliance, and applicable delivery teams to ensure systems are fit for purpose, compliant, validated as needed, and able to support operational growth.
- Maintain executive accountability for technology outcomes across the R&D and TechOps portfolio, including delivery performance, adoption, value realization, operational readiness, and risk management.
- Partner with R&D and TechOps leaders as they build more internal business capability and reduce reliance on external partners, ensuring the technology landscape evolves alongside those operating model changes.
- Work closely with internal Data & AI teams to ensure R&D and TechOps needs are represented in Madrigal’s broader enterprise data strategy.
- Ensure delivery teams, managed service providers, domain experts, and strategic partners understand business objectives, success measures, compliance expectations, and operating requirements.
- Manage vendors and external partners supporting the Scientific IT portfolio, ensuring accountability for service quality, delivery outcomes, and long-term supportability.
- Ensure Scientific IT initiatives follow appropriate controls for GxP, CSV / CSA, 21 CFR Part 11, data integrity, privacy, security, audit readiness, and inspection support.
- Build the right mix of business partnership, product ownership, application management, vendor oversight, compliance awareness, and delivery leadership within the Scientific IT team.
- Drive continuous improvement in how IT engages with R&D and TechOps, moving from reactive support to proactive strategic partnership.
- Build and evolve the Scientific IT organization, including talent, structure, capabilities and sourcing strategy, to create sustainable internal ownership while strategically leveraging external partners.
- Create a culture of ownership, service, accountability, and practical problem-solving across the Scientific IT organization.
Qualifications
- Bachelor’s degree in Computer Science, Information Systems, Engineering, Life Sciences, Business, or a related field required.
- Advanced degree, such as an MBA, MS, or related graduate degree, preferred.
- Equivalent combination of education and relevant experience may be considered.
- Typically requires 20+ years of progressive experience in IT, digital, technology strategy, business partnership, enterprise applications, or related technology leadership roles.
- Significant experience in biotech, pharmaceutical, life sciences, or other regulated healthcare environments required.
- Demonstrated experience partnering with senior executives or functional leadership teams to translate business strategy into technology roadmaps and investment plans.
- Strong understanding of R&D and / or TechOps business processes, systems, data needs, compliance requirements, and operating models.
. We must not repeat job title as heading. No Job ID etc. Remove boilerplate. So we need to extract substantive content. Let's craft About the role: combine company description and role overview paragraphs before "Key Responsibilities". That includes: Madrigal is a biopharmaceutical company... The Vice President, Scientific IT Business Partner will lead... etc up to "This is a senior IT leadership role that requires deep life sciences technology experience, strong executive influence, and the ability to operate across strategy and execution." That's the overview. We'll put that in
maybe multiple paragraphs. Responsibilities: list from "Key Responsibilities" bullet points. There are several categories with sub-bullets. We'll flatten into a list of responsibilities. Could keep sub-bullets as nested
- but instruction says use
- for any list of duties/requirements/benefits. Could do top-level
- with each responsibility as
- . Might include subpoints as separate
- as well. We'll just list each bullet point as
- . Ensure we preserve all substantive information. Qualifications: Education and Experience sections. We'll list Education bullet points (Bachelor's degree required, Advanced degree preferred, Equivalent combination...). Experience bullet points (Typically requires 20+ years..., Significant experience..., Demonstrated experience..., Strong understanding..., Experience leading..., Experience building..., Experience managing..., Experience operating..., Experience with leading...). We'll put each as
- .
We must not include Benefits, Pay, Schedule.
Let's craft HTML.
We'll start with maybe not required; just output fragment. Use
headings. Thus:
About the role
Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH. Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c). Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way. The Vice President, Scientific IT Business Partner will lead Madrigal’s Scientific IT Business Partnership, supporting the company’s Research & Development and Technical Operations organizations. This role will serve as the senior IT partner to the R&D and TechOps executive leadership teams, translating functional strategy into technology roadmaps, portfolio priorities, operating capabilities, and delivery outcomes. As Madrigal continues to grow, the technology needs across R&D and TechOps are becoming more complex, interconnected, and critical to the company’s ability to execute. This leader will help mature how IT supports the scientific value chain, bringing both domains together with a breadth to lead across an interconnected landscape, ensuring the right systems, data, integrations, processes, partners, and internal capabilities are in place to support clinical development, regulatory progression, quality, manufacturing, supply, and continued operational scale. This is a senior IT leadership role that requires deep life sciences technology experience, strong executive influence, and the ability to operate across strategy and execution.
Responsibilities
- Serve as the senior IT business partner for Madrigal’s R&D and TechOps organizations, building trusted relationships with the respective ELT members and their leadership teams.
- Translate R&D and TechOps business strategies into multi-year technology roadmaps, investment priorities, and portfolio plans.
- Develop sufficient digital breadth across the scientific value chain to anticipate cross functional implications and ensure technology decisions made within one domain support the broader R&D and TechOps strategy.
- Provide strategic technology guidance across the scientific value chain, including clinical development, regulatory, quality, manufacturing, supply chain, CMC, and related scientific business capabilities.
- Partner with business leaders to identify opportunities where technology, data, automation, and AI can improve speed, quality, compliance, visibility, and decision-making.
- Represent R&D and TechOps needs within ITLT and enterprise governance forums, ensuring scientific priorities are visible, well-understood, and appropriately sequenced.
- Navigate competing priorities across R&D and TechOps, facilitating balanced recommendations that align with enterprise and corporate objectives.
- Own the Scientific IT portfolio across R&D and TechOps, including roadmap development, investment planning, prioritization, and value realization.
- Maintain an integrated view of technology needs, investments, dependencies, and risks across the scientific value chain.
- Partner with PMO and IT leadership to ensure initiatives are appropriately scoped, sequenced, resourced, governed, and delivered.
- Develop clear business cases for technology investments, including expected value, risk, implementation approach, resource needs, and long-term operating implications.
- Make start / stop / sequence recommendations for Scientific IT initiatives based on business value, risk, capacity, dependencies, and strategic alignment.
- Ensure Scientific IT roadmaps are realistic, integrated, and aligned with enterprise architecture, data strategy, cybersecurity, infrastructure, and compliance expectations.
- Provide executive-level visibility into portfolio health, delivery risks, resource constraints, and key decisions needed to keep work moving.
- Lead IT partnership and delivery for R&D functions, with near-term emphasis on Clinical Development and Regulatory capabilities.
- Support the continued buildout of Madrigal’s R&D technology landscape, including systems and capabilities that enable clinical execution, regulatory operations, scientific collaboration, data flow, inspection readiness, and decision-making.
- Bring strong working knowledge across R&D technology domains, while leveraging and growing internal and external subject matter expertise where deeper specialization is required.
- Partner with R&D leaders to identify technology needs across the development lifecycle and translate those needs into practical, scalable solutions.
- Connect technology decisions across Clinical, Regulatory, Safety, Data and other R&D capabilities to reduce fragmentation and create an integrated scientific technology landscape.
- Ensure R&D technology investments support clinical operations, regulatory milestones, data quality, compliance, and business agility.
- Strengthen internal ownership of critical R&D technology capabilities that require business context, continuity, and close alignment with scientific priorities.
- Lead IT partnership and delivery for TechOps functions, including CMC, Quality, Manufacturing, Supply Chain, and related operational capabilities.
- Apply broad understanding of the TechOps technology landscape while drawing on specialized expertise across Quality, Manufacturing, Supply Chain, CMC and other domains as needed.
- Build trusted relationships with TechOps leaders to understand business priorities, operational risks, external partner dependencies, and technology needs.
- Help mature the TechOps technology roadmap as Madrigal scales its manufacturing, quality, supply, and product lifecycle capabilities.
- Provide strategic oversight of across systems and capabilities such as QMS, LIMS, ERP, serialization, supply planning, quality documents, deviation / CAPA / change control, batch records, external manufacturing portals, and related manufacturing or quality systems.
- Identify opportunities to improve visibility, data flow, process consistency, and decision-making across internal teams and external manufacturing / supply partners.
- Lead the Scientific IT Business Partnership organization and ensure it can scale with the evolving needs of R&D and TechOps.
- Build and evolve the Scientific IT organization with the right combination of domain depth and cross functional breadth, ensuring specialized expertise is available where required while maintaining an integrated view across the scientific value chain.
- Own the Scientific IT application portfolio across R&D and TechOps, including lifecycle management, roadmap alignment, enhancement planning, operational support, and continuous improvement.
- Establish a clear service delivery model for Scientific IT, including support expectations, ownership, escalation paths, vendor responsibilities, performance management, and business continuity.
- Partner with Quality, IT Compliance, and applicable delivery teams to ensure systems are fit for purpose, compliant, validated as needed, and able to support operational growth.
- Maintain executive accountability for technology outcomes across the R&D and TechOps portfolio, including delivery performance, adoption, value realization, operational readiness, and risk management.
- Partner with R&D and TechOps leaders as they build more internal business capability and reduce reliance on external partners, ensuring the technology landscape evolves alongside those operating model changes.
- Work closely with internal Data & AI teams to ensure R&D and TechOps needs are represented in Madrigal’s broader enterprise data strategy.
- Ensure delivery teams, managed service providers, domain experts, and strategic partners understand business objectives, success measures, compliance expectations, and operating requirements.
- Manage vendors and external partners supporting the Scientific IT portfolio, ensuring accountability for service quality, delivery outcomes, and long-term supportability.
- Ensure Scientific IT initiatives follow appropriate controls for GxP, CSV / CSA, 21 CFR Part 11, data integrity, privacy, security, audit readiness, and inspection support.
- Build the right mix of business partnership, product ownership, application management, vendor oversight, compliance awareness, and delivery leadership within the Scientific IT team.
- Drive continuous improvement in how IT engages with R&D and TechOps, moving from reactive support to proactive strategic partnership.
- Build and evolve the Scientific IT organization, including talent, structure, capabilities and sourcing strategy, to create sustainable internal ownership while strategically leveraging external partners.
- Create a culture of ownership, service, accountability, and practical problem-solving across the Scientific IT organization.
Qualifications
- Bachelor’s degree in Computer Science, Information Systems, Engineering, Life Sciences, Business, or a related field required.
- Advanced degree, such as an MBA, MS, or related graduate degree, preferred.
- Equivalent combination of education and relevant experience may be considered.
- Typically requires 20+ years of progressive experience in IT, digital, technology strategy, business partnership, enterprise applications, or related technology leadership roles.
- Significant experience in biotech, pharmaceutical, life sciences, or other regulated healthcare environments required.
- Demonstrated experience partnering with senior executives or functional leadership teams to translate business strategy into technology roadmaps and investment plans.
- Strong understanding of R&D and / or TechOps business processes, systems, data needs, compliance requirements, and operating models.