VP, Head of Preclinical Development
BioSpace · Somerset, NJ · 3 wk ago
Hybrid$294k–$387k/yrFull-time
We need to output HTML fragment with sections: h3 headings for sections present: About the role, Responsibilities, Requirements, Qualifications? The posting includes "Role Overview" maybe treat as About the role. Also "Key Responsibilities". "Requirements". Also "Other Types of Pay", "Benefits and Paid Time Off", "Pay Range (Base Pay)". Also maybe "Work Authorization & Employment Eligibility" but that's boilerplate? It's not EEO but it's about work auth; we might keep? The instruction: Remove cookie/navigation/legal/EEO/equal-opportunity/scam-warning boilerplate, duplicated lines, and application instructions. Work Authorization & Employment Eligibility might be considered legal boilerplate? It's about compliance; likely should be removed. Also EEO statement removed. Also "Please note: These benefits are offered exclusively to permanent full-time employees." That's part of benefits; keep? It's a note about benefits eligibility; could be included in Benefits section.
We need to preserve all substantive information. So include sections: About the role (role overview), Responsibilities (key responsibilities), Requirements (list), Benefits (including benefits and PTO, note about full-time), Pay (base pay range, other types of pay). Possibly also "Qualifications" but we have Requirements covering qualifications; we could combine. The instruction: Use headings for section headings (e.g. About the role, Responsibilities, Requirements, Qualifications, Skills, Benefits, Pay, Schedule). We can choose which are present. We have About the role, Responsibilities, Requirements, Benefits, Pay. No Schedule. No Skills separate.
We must not repeat job title as heading. The page already shows it, so we don't add a heading for "VP, Head of Preclinical Development". Good.
We need to use
- for any list of duties/requirements/benefits. So for responsibilities list, requirements list, benefits list.
We need to use
for prose. We must not include filler headings with no content. Let's extract content. About the role: The paragraph(s) under "Role Overview". It includes: "Legend Biotech is a clinical-stage biotech company developing cell therapies for hematological malignancies, solid tumors and autoimmune diseases. We are seeking an exceptional scientist-leader to serve as Vice President, Head of Preclinical Development. This is a senior, externally visible leadership role accountable for the full preclinical development program across in vitro pharmacology, in vivo pharmacology, and toxicology for all pipeline compounds globally. The person will build and lead a high-performing, integrated team, set scientific standards for the organization, and serve as the internal authority and external face for preclinical science across regulatory, partnership, and publication contexts." We can put that as
under
About the role
. Responsibilities: bullet list under "Key Responsibilities". Let's capture each bullet: - Define and execute the preclinical development strategy across all pipeline program globally from candidate nomination through IND-enabling studies. - Serve as the internal scientific authority on in vitro pharmacology, in vivo pharmacology, and toxicology — setting methodological standards, experimental design principles, and data interpretation frameworks. - Lead preclinical science for novel modalities including lentiviral vector-based in vivo CAR-T, ex vivo cell therapies, and gene-modified immune cell platforms, with deep understanding of the unique preclinical characterization requirements of each - Integrate preclinical datasets (PK, PD, safety, biodistribution etc) into coherent compound narratives that inform clinical development strategy, dose selection, and regulatory submissions. - Contribute to portfolio decisions by providing rigorous preclinical risk assessments for new candidates, partnership assets, and lifecycle management opportunities. - Own the preclinical component of IND applications, accountable for integrated pharmacology and toxicology summaries, study tabulations, and the Written Summary of nonclinical pharmacology and toxicology. - Build, lead, and develop a high-performing Preclinical Development team comprising in vitro pharmacology scientists, in vivo pharmacology scientists, and toxicologists — both internal staff and embedded CRO personnel. - Set a culture of scientific excellence, objectivity, and regulatory integrity — where data are interpreted accurately regardless of programme pressure and where safety signals are escalated promptly and without bias. - Mentor and develop team members at all levels; create individual development plans, provide regular performance feedback, and support career progression. We'll put each as - .
Requirements: list under "Requirements". Let's capture:
- PhD in pharmacology, toxicology, immunology, cell biology, or a closely related discipline.
- Minimum 15 years of progressive experience in preclinical drug development, with at least 5 years in a senior leadership role with direct accountability for IND-enabling programs.
- Deep expertise in at least two of the three core functions (in vitro pharmacology, in vivo pharmacology, toxicology), with working knowledge of the third.
- Demonstrated experience designing, overseeing, and interpreting GLP toxicology studies (repeat-dose NHP or rodent, safety pharmacology, genotoxicity) in support of IND filing.
- Experience in cell therapy, gene therapy, or advanced therapy development.
- Track record of successful IND submissions with clear accountability for the nonclinical pharmacology and toxicology sections.
- Experience managing CRO relationships for outsourced preclinical and GLP studies, including vendor qualification, protocol development, monitoring, and report review.
- Proven ability to lead, mentor, and build high-performing scientific teams in a fast-paced biotech environment.
We'll put as
- .
Benefits: The paragraph under "Benefits and Paid Time Off:" plus note about permanent full-time employees.
Content: "Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work."
Note: "Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech."
We can combine into a
- list? The instruction: Use
- for any list of duties/requirements/benefits. So we can turn benefits into list items. Could break each sentence into list items. But we could also keep as prose
. The rule says use
- for any list of duties/requirements/benefits. Benefits is a list; better to make list.
Let's create list items:
- Medical, dental, and vision insurance
- 401(k) retirement plan with a company match that vests fully on day one
- Eight (8) weeks of paid parental leave after three (3) months of employment
- Paid time off policy including vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays
- Additional voluntary benefits: flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance
- Voluntary commuter benefits, family planning and care resources, well-being initiatives, peer-to-peer recognition programs
- Note: These benefits are offered exclusively to permanent full-time employees; contractors are not eligible.
We could keep note as separate
maybe. But it's still benefit-related; we can include as list item. Pay: includes "Other Types of Pay: Performance-based bonus and/or equity is available to employees in eligible roles." and "Pay Range (Base Pay) $294,483 - $386,511USD". Also maybe note about actual compensation may vary etc. That's prose. We should create a Pay section with maybe
for base pay range and other types of pay. We must not include filler like "commensurate with experience". Not present. We must not include duplicated lines. Now produce HTML fragment:
About the role
Legend Biotech is a clinical-stage biotech company developing cell therapies for hematological malignancies, solid tumors and autoimmune diseases. We are seeking an exceptional scientist-leader to serve as Vice President, Head of Preclinical Development. This is a senior, externally visible leadership role accountable for the full preclinical development program across in vitro pharmacology, in vivo pharmacology, and toxicology for all pipeline compounds globally. The person will build and lead a high-performing, integrated team, set scientific standards for the organization, and serve as the internal authority and external face for preclinical science across regulatory, partnership, and publication contexts.
Responsibilities
- Define and execute the preclinical development strategy across all pipeline programs globally from candidate nomination through IND-enabling studies.
- Serve as the internal scientific authority on in vitro pharmacology, in vivo pharmacology, and toxicology — setting methodological standards, experimental design principles, and data interpretation frameworks.
- Lead preclinical science for novel modalities including lentiviral vector-based in vivo CAR-T, ex vivo cell therapies, and gene-modified immune cell platforms, with deep understanding of the unique preclinical characterization requirements of each.
- Integrate preclinical datasets (PK, PD, safety, biodistribution etc) into coherent compound narratives that inform clinical development strategy, dose selection, and regulatory submissions.
- Contribute to portfolio decisions by providing rigorous preclinical risk assessments for new candidates, partnership assets, and lifecycle management opportunities.
- Own the preclinical component of IND applications, accountable for integrated pharmacology and toxicology summaries, study tabulations, and the Written Summary of nonclinical pharmacology and toxicology.
- Build, lead, and develop a high-performing Preclinical Development team comprising in vitro pharmacology scientists, in vivo pharmacology scientists, and toxicologists — both internal staff and embedded CRO personnel.
- Set a culture of scientific excellence, objectivity, and regulatory integrity — where data are interpreted accurately regardless of programme pressure and where safety signals are escalated promptly and without bias.
- Mentor and develop team members at all levels; create individual development plans, provide regular performance feedback, and support career progression.
Requirements
- PhD in pharmacology, toxicology, immunology, cell biology, or a closely related discipline.
- Minimum 15 years of progressive experience in preclinical drug development, with at least 5 years in a senior leadership role with direct accountability for IND-enabling programs.
- Deep expertise in at least two of the three core functions (in vitro pharmacology, in vivo pharmacology, toxicology), with working knowledge of the third.
- Demonstrated experience designing, overseeing, and interpreting GLP toxicology studies (repeat-dose NHP or rodent, safety pharmacology, genotoxicity) in support of IND filing.
- Experience in cell therapy, gene therapy, or advanced therapy development.
- Track record of successful IND submissions with clear accountability for the nonclinical pharmacology and toxicology sections.
- Experience managing CRO relationships for outsourced preclinical and GLP studies, including vendor qualification, protocol development, monitoring, and report review.
- Proven ability to lead, mentor, and build high-performing scientific teams in a fast-paced biotech environment.
Benefits
- Medical, dental, and vision insurance
- 401(k) retirement plan with a company match that vests fully on day one
- Eight (8) weeks of paid parental leave after three (3) months of employment
- Paid time off policy including vacation time
- for any list of duties/requirements/benefits. Benefits is a list; better to make list.
Let's create list items:
- Medical, dental, and vision insurance
- 401(k) retirement plan with a company match that vests fully on day one
- Eight (8) weeks of paid parental leave after three (3) months of employment
- Paid time off policy including vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays
- Additional voluntary benefits: flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance
- Voluntary commuter benefits, family planning and care resources, well-being initiatives, peer-to-peer recognition programs
- Note: These benefits are offered exclusively to permanent full-time employees; contractors are not eligible.
We could keep note as separate
- for any list of duties/requirements/benefits. So we can turn benefits into list items. Could break each sentence into list items. But we could also keep as prose
- .
Benefits: The paragraph under "Benefits and Paid Time Off:" plus note about permanent full-time employees.
Content: "Medical, dental, and vision insurance as well as a 401(k) retirement plan with a company match that vests fully on day one. We offer eight (8) weeks of paid parental leave after just three (3) months of employment, and a paid time off policy that includes vacation time, personal time, sick time, floating holidays, and eleven (11) company holidays. Additional voluntary benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide voluntary commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs; demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work."
Note: "Please note: These benefits are offered exclusively to permanent full-time employees. Contractors are not eligible for benefits through Legend Biotech."
We can combine into a