Vice President, Gene Editing Core
Job Summary
The Vice President, Gene Editing Core leads a highly cross-functional team applying state-of-the-art genomic and molecular biology tools to advance genome editing therapies. This role will oversee the planning, execution, and delivery of projects to support early research and development studies, developing assays and reagents to characterize gene editing outcomes including on and off-target as well as structural variant assessment. This leadership role supports the advancement of platform improvements and novel nucleases into therapeutic programs. This highly visible R&D cross functional leadership role is integral to advancing therapeutic programs and innovative platform solutions.
Key Responsibilities
Strategic Planning and Leadership: Creates and leads vision of genomics innovation to support research in developing gene-editing therapies
Collaborates across Platform Innovation and Delivery Innovation to advance novel nucleases, insertion strategies, new technologies, delivery advancements, and develop assays to assess the potential for unintended genomic changes
Screens efforts generating data in support of advancing the pipeline programs and platform improvements including guide RNA, messenger RNA, and delivery optimization as well as novel nuclease advancement
Oversees NGS production efforts, running AMP-seq, off-target discovery, off-target confirmation, and structural variant analysis
Pairs with computational biology, software engineering, and automation on data analysis, data capture, and workflow optimization
Evaluates and adopts new technologies and platforms to improve methods and technology in support of the company’s strategic direction
Ensures proper documentation, sample tracking, compliance with regulations, guidelines, and standards related to genomic research, data management, and biosafety protocols
Communicates with users, providing guidance, and bringing in external consultant and collaborators as needed
Serves as a functional representative for program teams, providing expertise and guidance on gene editing methods to support development candidate nomination and regulatory filing
Fosters a culture of collaboration, innovation, teamwork, and communication, and handle discipline and termination of employees in accordance with company policy
Provide strategic direction and oversight to the Computational Biology team, ensuring efficient and effective daily operations
Foster a high-performing team through: Talent acquisition and recruitment, Comprehensive training and development programs, Strategic staff assignment and resource allocation, Coaching and mentoring to enhance individual and team performance, Development and implementation of key performance metrics and evaluation frameworks
Lead, mentor, and develop a team of scientists, fostering a culture of collaboration, innovation, and teamwork
Oversee the daily workflow of the Gene Editing Core teams, ensuring efficient and effective operations
Grow and maintain a high-performing team, including hiring, training, staff assignment, coaching, mentoring, and performance management
Cultivate a Collaborative And Innovative Work Environment That Promotes Open communication and transparency, Cross-functional teamwork and knowledge sharing, Continuous learning and professional growth
Ensure adherence to company policies and procedures, including: Addressing performance issues and implementing corrective actions as needed, Managing employee discipline and termination in accordance with company guidelines and regulations
Skills/Abilities
Extensive experience in genomics: Including experience with sequencing technologies and genomic data analysis
Knowledge of compliance requirements related to genomic research and data management
Experience with various genomic technologies: Including NGS, ddPCR, single-cell genomics, and spatial transcriptomics
Strong foundation in experimental design and bioinformatics: Ability to design experiments, analyze data, and interpret results
Leadership and Management: Proven experience in leading a team of core function scientists and managing multiple projects simultaneously, experience leading projects, and overseeing laboratory operations
Communication and Collaboration: Excellent communication and interpersonal skills, with the ability to collaborate effectively with cross-functional teams
Regulatory Knowledge: Familiarity with relevant regulatory standards and guidelines
Problem-Solving and Analytical Skills: Ability to analyze complex problems, identify solutions, and implement them effectively
Industry Knowledge: Deep understanding of the relevant industry and its trends, including preclinical and clinical research