Temporary Scientist I, Computational Chemistry

Temporary W2 contract role based in Redwood City, CA (onsite).

About the role

We are seeking a motivated Computational Chemist to join our dynamic team. This position offers an exciting opportunity to drive drug discovery through cutting-edge computational methods, working at the intersection of structural biology, medicinal chemistry, biology, and data science to accelerate the development of transformative therapeutics for patients.

Responsibilities

• Determine, propose, and implement ML methodologies, analyze large data, and document research to identify clustering methods for Macrocycles.
• Work with software packages/GitHub repositories, test, and use them.
• Design and implement virtual screening workflows leveraging both structure-based and ligand-based computational methods to discover novel hit compounds and accelerate lead optimization processes.
• Partner with multidisciplinary, collaborative teams in Discovery Sciences to help analyze structure-activity relationships (SAR) and make data-driven decisions by following existing SAR trends to design strategies for Ro5 and bRo5 molecules.
• Devise and execute strategies to augment hit-finding abilities by designing diverse chemical libraries.

Requirements

• Ph.D. in computational chemistry or related field.
• Understanding of contemporary computational chemistry methods and their use in protein-ligand analysis and drug design, such as docking, virtual screening, pharmacophore modeling, MD simulation, QM calculations, etc.
• Experience with computational chemistry, cheminformatics, data science, and machine learning software.
• Scientific programming or scripting in Bash, Python, R, Java, C, or similar languages.
• Excellent oral and written communication skills.
• Experience in positively influencing team decisions and effectively collaborating across multidisciplinary environments.
• Driven by a desire to be innovative and creative in a high-energy, fast-paced environment.

Skills

• Computational Chemistry
• Cheminformatics
• Machine Learning
• Data Science
• Structural Biology
• Medicinal Chemistry
• Drug Discovery
• Large-Scale Data Analysis
• Clustering Methodologies
• Macrocycles
• Protein-Ligand Analysis
• Molecular Docking
• Virtual Screening
• Structure-Based Drug Design
• Ligand-Based Drug Design
• Pharmacophore Modeling
• Molecular Dynamics Simulation
• Quantum Mechanics Calculations
• Structure-Activity Relationships
• Lead Optimization
• Hit Discovery
• Chemical Library Design
• Ro5 Molecules
• bRo5 Molecules
• Scientific Programming
• Bash, Python, R, Java, C
• GitHub
• Software Package Testing
• Research Documentation
• Data-Driven Decision-Making
• Multidisciplinary Collaboration
• Scientific Communication
• Innovation

Pay

$55 - $65 per hour.