T Cell Engineering & Translation Lead
About the role
The role is responsible for leading the engineering, process development, and translational advancement of TCR engineered T cell therapies from candidate nomination through clinical readiness. The role drives vector design, cell engineering, and preclinical development of next-generation TCR-T cell therapies incorporating viral and non-viral ex vivo engineering as well as in vivo T cell therapy strategies.
Responsibilities
- Develop effective in vivo T cell engineering strategies and delivery vectors.
- Lead optimization of vector design (viral and non-viral) to be used for in vivo and ex vivo generation of armored TCR-T cells.
- Collaborate with director of Vector Production and Quality to ensure seamless transition of preclinical products into a scalable clinical process.
- Evaluate TCR constructs for stability, reactivity, and manufacturability in collaboration with engineering and translational staff.
- Oversee development and optimization of ex vivo TCR manufacturing processes inclusive of transduction/transfection, expansion and formulation.
- Establish scalable workflows for rapid ex vivo cell engineering to enhance product potency.
- Conduct IND enabling studies integrating in vivo pharmacology, safety, potency and mechanism-of-action datasets.
- Serve as a liaison between discovery and manufacturing teams to enable technology transfer and feasibility.
- Collaborate with manufacturing team to assess product and process performance, troubleshoot issues, and drive enhancements in clinical cell therapy manufacturing.
- Collaborate with the quality team to develop bespoke assays to assess product potency.
- Ensure documentation standards consistent with future IND submissions in all IND-enabling studies.
Requirements
Master's Degree or Ph.D. in an appropriate field. Equivalent work experience will be considered.
Experience: 10 years of experience in T cell engineering or cell/gene therapy development with demonstrated experience in lentiviral vector systems, non-viral gene engineering platforms, human T cell functional biology, in vivo gene delivery approaches. Approximately 3 years or related experience in advanced translational academic center or Pharmaceutical environment, with evidence of leading IND-enabling preclinical development (industry preferred).
Knowledge, Skills and Abilities: In-depth knowledge of interpreting TCR-T cell biology, receptor engineering, and gene modification platforms. Knowledge of vector design principles, optimization, and safety switch technologies. Demonstrates ability to apply analytical methodologies for cell therapy characterization. Familiarity with institutional and federal regulatory documentation and compliance standards. Demonstrates understanding of translational development pathways from preclinical through early-phase clinical trials. Ability to build scalable and reproducible identification pipelines for personalized TCR therapy programs.
Qualifications
Education: Master's Degree or Ph.D. in an appropriate field.
Skills
Master's Degree or Ph.D. in an appropriate field. Equivalent work experience will be considered.
Experience: 10 years of experience in T cell engineering or cell/gene therapy development with demonstrated experience in lentiviral vector systems, non-viral gene engineering platforms, human T cell functional biology, in vivo gene delivery approaches. Approximately 3 years or related experience in advanced translational academic center or Pharmaceutical environment, with evidence of leading IND-enabling preclinical development (industry preferred).
Knowledge, Skills and Abilities: In-depth knowledge of interpreting TCR-T cell biology, receptor engineering, and gene modification platforms. Knowledge of vector design principles, optimization, and safety switch technologies. Demonstrates ability to apply analytical methodologies for cell therapy characterization. Familiarity with institutional and federal regulatory documentation and compliance standards. Demonstrates understanding of translational development pathways from preclinical through early-phase clinical trials. Ability to build scalable and reproducible identification pipelines for personalized TCR therapy programs.
Pay
$165,700.00 - $188,000.00
Schedule
Weekly Hours: 35.00
Exemption Status: Exempt